The Big & Dandy Methoxetamine Thread-11th Dose-50 grams and a kidney later..

[Sweetshare]

Cryptix420 - I'm looking at the large view. Genes are subject to variations(or errors, depending on how you look at it). Survival favors those variations which result in survival. This is evolution. Humans have reached a point where we can save many, many more people than in hunter/gatherer times. This has resulted in variations surviving with the individual persons experiencing varying degrees of suffering. Would you tell a mentally disabled person to find their inner happiness(which is very vague with no definite instructions or guaranteed results). Or if a drug or device were to ease their suffering, is that unacceptable, they should tough it out, because your worldview says that's how it should be? I say use, and ease the suffering. I am not autistic, but I do have problems which I think are "wired in", just like I have an auto-immune disease which also causes suffering.

This person said that I wanted to say for a long time, but I did not know enough English to say as well.
I totally agree.

 

[how the gods chill]

You should try staggered dosing next time to reduce the confusion (this was discussed a couple of pages back, but I can't blame you for not reading on it given the amount of silly hate we were throwing at each other) - 20mg sublingual 3 times, with 40 minute breaks between each dose, for a total of 60mg, will get you into a much gentler yet equally tripply place, without all the "what the fuck" chaos of an equal dose done in one go. Is MXE your first dissociative?

You can also try plugging, which is very effective but can also be quite chaotic as it's far stronger than snorted on a mg-per-mg basis and with a quicker onset time. What I do is dissolve about 60mg in a 5ml syringe without the needle and plug a third of it every 20 minutes. It's very tranquil if you take your time easing into it, and you can gently slip into a hole without freaking out.

Okay, I will definitely dose like you suggested, I plan on expirementing with mxe again. Yes, also my first encounter with dissasociatives. Had no idea what to expect, we put on Alice in wonderland and i laid down and got lost in it, wasn't sure if i was dreaming or sleeping or what. I was aware of my consciousness but that's about it haha so wild.

 

[25I_am_so_wonderfu]

Okay, I will definitely dose like you suggested, I plan on expirementing with mxe again. Yes, also my first encounter with dissasociatives. Had no idea what to expect, we put on Alice in wonderland and i laid down and got lost in it, wasn't sure if i was dreaming or sleeping or what. I was aware of my consciousness but that's about it haha so wild.

Show me... How the Gooooods chill

 

[dezz]

Just bumped 10 mg's. Low doses off this stuff is great aswell, almost something like weed but better

 

[crazycatman]

Speaking of addiction, anyone ever got bored of mxe?

My first few times I liked it but then all of a sudden I have absolutely no wish to take any more. And no I didn't have a bad experience or anything like that.

 

[THCified]

Don't make any "decisions" on MXE, my experience tells. Your mind is blunted and foolish on MXE.

I wouldn't say that. You can make very valuable decisions while on MXE, it's just not that easy to distinguish the foolish from the ingenious ones

Btw, has someone tried combining MXE with 4-HO-MiPT!?

 

[Limitbreaker]

Btw, has someone tried combining MXE with 4-HO-MiPT!?

I've tried it with acodmt, it surely is awesome combo, like most mxe + psychedelics

 

[TheAppleCore]

MXE and 4-HO-MiPT is a wicked awesome idea. Someone must try it. :D

I would say, get a solid +++ going with the 4-HO-MiPT, then add just enough MXE to take your feet off the ground a couple inches, give the whole trip a frictionless aerodynamic quality.

 

[psood0nym]

That sucks... last thing I need is another SERT releaser... bummer tbh

Two users in the ADD thread for discussing that study state that the SERT activity of MXE is unlikely to effect the experience at normal doses, and nobody argued to the contrary. I'm guessing if it was chronically abused it could result in significant depletion over time though as the authors do indicate it causes some serotonin release and after a single dose of a strong releaser like MDMA serotonin rebound in humans is thought to take a month or more.

That study is intriguing, though. However MXE does what it does its binding profile is not telling the full story, or even giving a very good summary.

 

[Solipsis]

Serotonin depletion? I could very well be missing that piece of data that says that MXE uses the SERT to deplete the presynaptic serotonin but right now I am only seeing an affinity for binding to it. Which will occupy and inhibit it at worst right?
Can you push this so far that the serotonin that missed reuptake is a quantity so lost that the previous level is not restored by normal metabolism??

Actually I could use a lecture on the detrimental effects of compounds such as EPH and MPH and how reuptake inhibition can cause forms of depletion.

 

[Transform]

I don't think the paper alludes to them being releasers at all.
The SERT affinity here is pretty low in the grand scheme - lower than any SSRI medication,

 

[psood0nym]

^It's not clear to me, either. I was merely speculating from earlier comments about the study regarding MXE abuse potentially causing depression by referring to the bit from the study shown in post 394 that says "... a resulting increase in the release of serotonin in the brain may contribute to its psychopharmacological profile ...". The authors use the word "release," and I assume they have a reason. If it's "released" I don't know where else it would be from but the presynaptic vesicles, resulting in reduction as MAO metabolizes serotonin stuck in the synapse that cannot be uptaken quickly enough ("depleted" was too strong a word).

It looks like the paper's authors are suggesting it inhibits the transporter and that subsequently results in a release heavy enough that it might be involved in acute MXE toxicity (I'm not sure of specifics). I think the paper is suggesting MXE be scheduled so all this may be based on speculations attempting to portray MXE in a negative light, mind you. I haven't read the full paper but I'm sure some of the ADD people in that thread I linked to have.

 

[TheAppleCore]

I still don't have a clear answer to my question, which is, what does affinity for the SERT do, and if it affects serotonin levels in the brain, how?

 

[THCified]

I've tried it with acodmt

Some time ago i had some K and as i came back from the depths of a hole, i ingested 20mgs 4-AcO-DMT rectally and had one of the best drug experiences ever.

That said, after thinking about trying out the MXE/4-HO-MiPT-Combo, i had some MXE (30mgs/oral) with some 4-AcO-DMT (20mgs/oral) yesterday. Without the slightest exaggeration this was BY FAR the best thing i could've done. If you think MXE is awesome and somewhat addictive, don't dare to think about trying this combo!

I mean, holy fuckin' Jesus, this was so good, it's beyond what words can say. Had i died and never did this combo, i'd surely missed the holy Grail of psychedelic madness. Besides the awesome feeling of being wrapped in a warm blanket, feeling content and calm, the wall of euphoria that hit me was so strong, i literally got raped by happiness!

Best thing is, there was zero bodyload, muscle tremors or anything else. Nothing!

If one wants to try this one, i'd suggest take your dose of MXE and when it starts to kick in, take the 4-AcO-DMT and fasten your seatbelts! It's really interesting how you can distinguish the effects of each substance even though you're totally out of this world.

Duration: approx. 5hrs.

 

[dezz]

Have to agree with you 100%. Low dose>high dose MXE (unless you build up the dose very gradually) for me. Unlike ketamine's completely clear inner-journey headspace MXE has *something* about it that, in high doses, has the potential to profoundly disrupt your sense of "I" and the "I"'s relationship to reality. I'm comfortable with that, on a blue moon, but I *strongly* advise against people new to dissociatives plunging into MXE head-first.

Treat it the way you would a glass of wine with a good book by a fireplace

It's all about what you like though. MXE is the only dissociative I've tried together with ketamine once in a blue moon and I love losing the sense of "I". Going that far on traditional psychedelics can make the earth tremble below my feet but MXE puts a warm blanket around me, puts a smile on my face and gently takes me to the insane psychedelic wonderland

 

[Transform]

If I am completely honest, I think that might be a typo. "Levels" would fit better there.

It's an understandable mistake to make, although if it was deliberate I doubt it would be in a propagandist fashion as the report was written for laymen with no idea of the consequences of serotonin release.

 

[mozokev]

Btw, has someone tried combining MXE with 4-HO-MiPT!?

Just tried this last night. Took 22mg of 4-HO-MiPT and about +2:30 took 20mg of MXE (insufflated). Very good combo that created an insanely enjoyable body high and head space.

 

[THCified]

^ Yes You're the Man, Bro!

Nicely done! Tbh i was a bit skeptical if the serotonergic impact of the 4-HO-MiPT (to me it felt as it was very strong acting on serotonin receptors) would combine well with the MXE, but after yesterdays fabulous experience (MXE + 4-AcO-DMT) i thought it simply must be a worthwhile combo!

Many thanks for your report!

 

[psood0nym]

I still don't have a clear answer to my question, which is, what does affinity for the SERT do, and if it affects serotonin levels in the brain, how?

Affininity can result in different responses depending on the properties of a drug, and is different from efficacy. This is an oversimplification, but basically if a drug has affinity for the serotonin transporter protein (SERT) but has no efficacy it's an antagonist (it just sits their getting in the way of other drugs like MDMA or natural neurotransmitters like serotonin). For example, the SERT inhibitor duloxetine mitigates the effects of MDMA, which partially works by reversing the action of SERT i.e. releases serotonin (also, don't confuse SERT, the serotonin pump, with 5HTx binding sites, as they're different things). That's what's confusing me about the segment of the paper posted. The authors talk of MXE both having affinity for and "inhibiting" the serotonin transporter protein, which sounds like antagonism (basically it plugs up the pump [SERT] that takes serotonin back into the neuron), but then go on to suggest there is a resulting increase in the release of serotonin (which sounds like a drug that reverses the activity of the protein, thereby pumping serotonin out instead of in). But I wouldn't expect that the release of serotonin would increase (it would just keep releasing normally but reuptake would be slowed because the transporter proteins are inhibited by MXE). In other words, it seems like inhibiting SERT should increase intracellular serotonin but not cause increased release, yet they seem to suggest MXE may cause increased release of serotonin despite this.

You'll get much more informed -- and far less cluttered -- responses asking questions in the ADD thread (where people have also read the whole paper).

 

[Transform]

The full document is available free from here. That is the only mention in the entire thing of increased release. Like I say, I think it's a typo.