Hmmm... nobody could say for sure what would happen. He might be fine, but I personally would absolutely not risk it. Stimulants can potentially increase risk of seizures as it is, and if his seizures came on from stress and anxiety from school exams, I would be concerned how he might respond to the possible stress and anxiety of a bad trip, or a shitty comedown. Maybe his seizures when he was a kid were just random and maybe he's fine now, but that's definitely pretty risky. Has he had any experience with any other drugs? If he chooses to do it anyways, he should definitely keep his dose on the lower side, and pace himself, like I said, stimulants in larger amounts can increase risk of seizures in people as it is... stick with friends who are aware of his "condition", so if something were to happen, there's someone there to help him and call for help.
I mean, who knows, he might be totally fine and might not even need to worry. Some people have a seizure during childhood and never have a problem with it again, but nobody can say for sure, so if he does choose to do MDMA, he should have a plan in place, be very informed about it all (seizures, warnings, MDMA effects, dosage, etc). I would also definitely abstain from mixing or taking anything else when he's on it.
Yeah, I dunnnnnooo... I can see why you're concerned, I would be too but education and keeping informed are key. If he's hell bent on doing it anyways, you can't really stop him, all you can do is make sure he's well informed about harm reduction and taking care of himself on it, dosage, etc and talk to him about having a simple plan in place, sticking with friends, etc. If I was him and I was going to do M, I would also make sure I was really informed about seizures, warning signs, etc.
He's smart to just take one pill, I think his risk would definitely be a lot higher if he was taking larger amounts. One pill shouldn't be that strong, but it totally depends on the ecstasy and what's actually in it. If it's weaker e than it might not have too much of an effect, but if its stronger e, he could be rolling blissfully for hours on a pill. It's hard to say because it all depends on quality, or if it's even actually MDMA. I'd recommend him taking one and seeing how it effects him first before taking anymore. That's a good rule for anybody actually, seizures or not.
Also, I imagine being overheated could also trigger a seizure in someone who's already susceptible, so tell him to keep hydrated and cool, especially if he's at a rave.