Benzos Things that temporarily increase Benzo Tolerance

[tricomb]

sorry for off topic but wow tricomb...you come off as a lot more mature than someone younger than 22. I'm 22 and I feel like your aged years beyond me in drug experience lol...don't know how much of a good thing is but hey knowledge is power.

Haha yeah like I said, I'm not proud of my experience, but it certainly has taught me a lot, and Knowledge Is Power!!! I was just putting that quote in my profile not five minutes ago. Go figure...

 

[HaZeX]

Look, the only person having a hard time understanding anything here is you. The FDA ALWAYS recommends the lowest effective dose, with alprazolam it is 250 mcg. If 125 mcg was any effective, the FDA would've had upjohn make 0.125 mg tablets and they would've been on the market. The reason they are not is because they do not produce any serious anxiety relief or sedation. But it doesn't and thus has no place in medical practice. Get it?

LOL, just because the FDA does this and does that doesn't mean the FDA is right. The point is, at 125mcg Alpraz. Is ACTIVE, which you seem to disagree with, but I digress. Just read Tricombs post above, which you so carefully skipped over and chose to respond to me. You chose to the argue the fact whether its active or inactive in the body, just because it doesn't produce effects like say 1000mcg would does not mean its not helping.
And lets not get snide with the comments. Got it?!?

You've got 2 people saying to you its active at 125mcg, but yet you choose to continue it further and say its not.

 

[tricomb]

This 0.25mg tablet is scored so that you can take doses of 125 micrograms. Why would they score it if it's not effective lower than 250 micrograms?

 

[alpralanon]

I recall, my girlfriend(now my wife), having a mild anxiety attack, we were on the 500 mcg footballs then, i thought to break one in half to be safe, half an hour
later, she was out cold. In retrospect, its amazing how much 1/4 gram of alpral. affected her, as now, 20 years down the long & windy road, we're struggling to
cut down from 4-6mg a day, due to the so-called 'better judgement' of these doctors who believe melatonin and efexor will be sufficient replacements. WTF?
Point being, 125mcg would have been enough to calm her down this day.

 

[HaZeX]

This 0.25mg tablet is scored so that you can take doses of 125 micrograms. Why would they score it if it's not effective lower than 250 micrograms?

Ive even said that, yet my counter argument was yet again, ineffective.

I recall, my girlfriend(now my wife), having a mild anxiety attack, we were on the 500 mcg footballs then, i thought to break one in half to be safe, half an hour
later, she was out cold. In retrospect, its amazing how much 1/4 gram of alpral. affected her, as now, 20 years down the long & windy road, we're struggling to
cut down from 4-6mg a day, due to the so-called 'better judgement' of these doctors who believe melatonin and efexor will be sufficient replacements. WTF?
Point being, 125mcg would have been enough to calm her down this day.

Yep alpraz. is pretty potent to a naive user, thats why it can be dosed so low.

 

[DaftPunkFan]

@daftpunk, you're going to be alright dosing 0.25mg of alprazolam according to my calculations with your taper, just don't go any higher than that, I recommend you sublingual it it's much more effective and I feel onset in 5-10 mins vs 15-20 orally. There are ways you could divide the .25mg into .125mg portions but if might not be worth the effort, and I think you'd be fine getting away with 250 micrograms.

Wish you the best of luck and cheers to a successful taper! I have nothing but good thoughts about your recovery, and if there's anything I can do, if you have any questions or whatever, feel free to PM me.

Thanks bro, I really appreciate it. I used to be prescribed those 0.25mg pills you posted, and yeah in the beginning my doctor even told me to break em in half if I only needed that much. Certainly effective at that dose, no doubt.

Look, the only person having a hard time understanding anything here is you. The FDA ALWAYS recommends the lowest effective dose, with alprazolam it is 250 mcg. If 125 mcg was any effective, the FDA would've had upjohn make 0.125 mg tablets and they would've been on the market. The reason they are not is because they do not produce any serious anxiety relief or sedation. But it doesn't and thus has no place in medical practice. Get it?

Thanks but... I don't give a shit. You win, stop arguing with people who clearly know what they're talking about.
Nobody ever asked what's the lowest possible Alprazolam dose someone could take and actually feel...

I recall, my girlfriend(now my wife), having a mild anxiety attack, we were on the 500 mcg footballs then, i thought to break one in half to be safe, half an hour
later, she was out cold. In retrospect, its amazing how much 1/4 gram of alpral. affected her, as now, 20 years down the long & windy road, we're struggling to
cut down from 4-6mg a day, due to the so-called 'better judgement' of these doctors who believe melatonin and efexor will be sufficient replacements. WTF?
Point being, 125mcg would have been enough to calm her down this day.

Yeah it's amazing how quickly doctors want to keep you going up on the dosage when I could have stuck with 0.25mg Xanax pills for anxiety.
Damn my taper would have been WAY over by now lol

 

[tricomb]

I've had multiple psychiatrists tell me that alprazolam is indeed active at 125 micrograms, I'm basing my statements off that and my own personal experiences.

From what I've heard..you don't wanna dicksize with tricomb.....
just sayin.........

`token

LOL, how did I miss this, you know me surprisingly well token, have you been spying on me?!

 

[Znegative]

Yes, I remember during a period where I had been off of benzo's for quite some time, .25mg really knocked me out, and I'm sure I would have felt half of that dosage. I believe though that such a low dosage would not remain therapeutic for long before tolerance weighed in, which is why the lowest dosage prescribed are the .25mg.

 

[ErgicMergic]

Kokaino, consider that Valium is active and prescribed at 2mg dosages for GAD for benzo naive people, and that 125 mcg of Xanax = 2.5mg Valium.

Xanax was approved with panic attacks as the primary target when they approved those dosages, not GAD. Daily Xanax dosages are taken for anxiolysis, while PRN Xanax dosages are taken only after a panic attack has begun. For an intense panic attack, though (prn), I would not want to take less than 250 mcg with a mild tolerance.

 

[tricomb]

I know many people who take it PRN (not daily), many are prescribed 0.25 or 0.5mg tablets because they aren't daily users, and I know that quite a few break their 250mcg tabs in half for 125mcg for PRN anxiety, even if it's only a few times a week, their tolerance isn't high enough to make 125mcg ineffective.

Even with my insane perma-tolerance to benzodiazepiens, and now the only benzos that actually still work for me are the triazolobenzodiazepines (alprazolam, triazolam), and even though to achieve complete anxiolysis, I'd need to take handfuls to bottles of alprazolam to get what most people feel at 2-4mg (with no tolerance), but I still dose small amounts, for alprazolam 2mg bars, I usually break off 1mg to start, then redose another 0.5mg later, and another 0.5mg later, and achieve nothing near relaxation, but it allows me to get over severe panic by relaxing me just enough to work on mental exercises like guided imagery, breathing techniques, removing stressful triggers from my environment, etc.

I use the triazolam for insomnia at doses between:

*125 micrograms, if used in combination with another sleeping pill like ~30mg temazepam
*And usually no more than 1mg when it's the only sleeping pill I'm taking.

 

[tokenname]

you know me surprisingly well token, have you been spying on me?!

TC: define spying...

oh....and you wish...

~token

 

[DaftPunkFan]

Kokaino, consider that Valium is active and prescribed at 2mg dosages for GAD for benzo naive people, and that 125 mcg of Xanax = 2.5mg Valium.

Yeah you're totally right. That's what I was saying, I dose 1.5mg Valium and I totally feel it for a while. And before I became addicted to benzos, I absolutely felt 2mg Valium pills. For someone to say that 2.5mg Valium isn't strong enough to be used for anxiety is just not true...

 

[tokenname]

^^he usually is^^

 

[tricomb]

Oh, as an afterthought, I'm pretty sure that carisoprodol increases your tolerance to benzodiazepines.

 

[tokenname]

+1 ^^^he's usually right too^^^

 

[kokaino]

Kokaino, consider that Valium is active and prescribed at 2mg dosages for GAD for benzo naive people, and that 125 mcg of Xanax = 2.5mg Valium.

Xanax was approved with panic attacks as the primary target when they approved those dosages, not GAD. Daily Xanax dosages are taken for anxiolysis, while PRN Xanax dosages are taken only after a panic attack has begun. For an intense panic attack, though (prn), I would not want to take less than 250 mcg with a mild tolerance.

Okay, you guys are mistaking active for therapeutic. Alprazolam does not have any appreciable therapeutic properties at 0.125 mg - point blank. Yeah it might be active - it's active at 0.05 mg as well, but that doesn't mean it has therapeutic value at that dose. All drugs are active in the human body no matter at what dose, but just because a drug is active it does not mean that it has any therapeutic value.

BTW, 2.5 mg diazepam does not equal 0.125 mg alprazolam.
10 mg diazepam = 0.5 mg alprazolam, 5 mg diazepam = 0.25 mg alprazolam and 0 mg diazepam = 0.125 mg alprazolam.

 

[tokenname]

Kokaino...
Honestly, I think you're mistaking everything.
It is possible...there are people out there who can find therapeutic vaue at .125 mg.
I'm sure as hell not one of them.
Neither are you.
That doesn't make it impossible.
I just think that being right isn't always the right thing..
and it's time ya'll let this go.
There's no agreement here. But there are grown ppl present in this discussion...right?
Agree to disagree?
Maybe moving on is the right thing....

~token

 

[som3dankbudz]

Ive even said that, yet my counter argument was yet again, ineffective.



Yep alpraz. is pretty potent to a naive user, thats why it can be dosed so low.

sdI agree with you, it's all based on a number of factors an individual's brain chemistry, past gabaergic drug use, and as someone said earlier. Elderly patients tend to be more senstive to benzodiazepines in general. Also you can't just say its implaussible that it's not therapeutic at that dose just because it doesn't effect YOU at that dose...but nuff said peace:D

 

[OverteHorizonRadar]

Bong rips and cigarettes work best for me

 

[Psychonauticunt]

Look, the only person having a hard time understanding anything here is you. The FDA ALWAYS recommends the lowest effective dose, with alprazolam it is 250 mcg. If 125 mcg was any effective, the FDA would've had upjohn make 0.125 mg tablets and they would've been on the market. The reason they are not is because they do not produce any serious anxiety relief or sedation. But it doesn't and thus has no place in medical practice. Get it?

... or maybe, because such a marginal group of the population would have need for a pill of only 0.125mg, the FDA asked Upjohn to score even the 0.25mg pills, so that the elderly who may need a lower dose can do that.

Look:

http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018276s045lbl.pdf

Dosing in Special Populations
In elderly patients, in patients with advanced liver disease or in patients with debilitating
disease, the usual starting dose is 0.25 mg, given two or three times daily. This may be
gradually increased if needed and tolerated. The elderly may be especially sensitive to the
effects of benzodiazepines. If side effects occur at the recommended starting dose, the dose
may be lowered.

I don't mean to sound arrogant but...

... but you're doing a poor job of it, I'm sorry to say.

Why else would they score the pill? Aesthetic reasons? I've personally been experienced and moderately tolerant to benzos and experienced relief with 0.25 - it doesn't seem completely ludicrous that half that dose could have an effect on someone. You may subjectively not get much from alprazolam, but saying it absolutely has no therapeutic value in medical practice is a weak argument if you base it on the FDA, when they quite clearly provide for a .125mg dose.