10mg Methadone PO TID *
1mg Clonazepam PO BID
15 mg Amphetamine Salts PO BID
*Though I may dose a filtered 10mg methadone soln NA qAM, qPM, and qhs,
Disposition of nasal, intravenous, and oral
methadone in healthy volunteers. NA = Nasal. If you filter the pills (I use roxanne tabs), then insufflate 10-20 mcL at a time, till the soln is gone, according to the study you will reach max plasma concentration of methadone in ~5-12 mins. Though I've noticed it takes a little longer because of the time needed to insufflate 5mg/mL soln of methadone, but I notice effects of the methadone with in 5 minutes. I use a homemade syringe filter (attaches to a syringe), using bits of pen parts, a double folded coffee circle (circumference of the tube) filter, with a loose bit of cotton ball between another double folded coffee filter circle. I've fucked up and made it so the filters were to thick/much that the particles of the pills clogged, so I try to minimize the cotton and only double thickness for the coffee filters. The filter attaches to a 5mL oral syringe, that I first put the crushed tabs/tab (finely powdered) and 2mL of bottled water using a 1mL oral syringe. I then, after shaking, and allowing for the solution to sit, I carefully squirt the soln through the filter into a 50ml Erlenmeyer flask (tilted using a homemade stand. Also I try to tilt 5ml syringe pointed up, just so much as to minizmize the amount of large particles passing through the filter). Of course next I use the 1 mL syringe to squirt 100-150 mcL (.10-.15mL) at a time in each nostril. I wait long enough for the my nose to feel mostly dry, then repeat. This seriously minimizes the loss of nasal potential from a drip.
In sum for nasal administration of filtered methadone soln from roxanne tabs, the burn that people experience (even noted in the article I posted) with snorting methadone, is minimized. Its no worse than snorting oxy 30 pills (if not better because of it being in a soln), or a few hours of ketamine imo. The faster you can dose it, with out losing potential nasal administration, it seriously will start to peak imo ~25 mins after fully dosing (with a 15min dose period). It gives a little rush that lasts at least 40 mins till it decreases over a 60-90min period to a essentially steady concentration for next 5-9 hours, declining steadily at a rate till the half-life of the individual. It lasts the same length as oral administration (~24 hour HL), comes on closer to IV methadone (fast enough to feel a rush like that of nasal oxycodone imo), and same or even potentially higher bioavailability than orally. I seriously notice that the BA for oral can change from dose to dose, assuming the state of the gastrointestinal tract plays a important role in this. With the nasal administration I don't notice that large of fluctuation unless I snort doses of soln larger than .25mL, from the drip. I will continue to dose nasal, and am promoting it because I see everywhere I look people saying snorting methadone is dumb (pills yeah, but a soln not really). I've even snorted a soln with out filtering with the homemade filter, and it did burn more, but still work almost just as well. I also eat the binders and fillers after snorting to make sure I don't look any amount of the methadone.
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
Sucks huh?
