For the mxe users, I just wanted to point this out. While this abstract is regarding ketamine, it likely applies to methoxetamine as well given their structural similarities and it's something every user should be aware of.
Conclusions These findings imply that heavy use of ketamine is harmful to aspects of both cognitive function and psychological wellbeing. Health education campaigns need to raise awareness among young people and clinicians about these negative consequences of ketamine use.
http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2009.02761.x/abstract
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