I find tolerance is a bit weird with MXE. Nowadays I can take 20 mg and e.g. have a conversation with my family or relatives without any problem. My first time with MXE was 25 mg and it felt like a real trip. There was no way I could have been in the presence of relatives then. Nowadays if I want to really trip on MXE I snort at least 60-80 mg and boost it with maybe 20-40 mg. Today I've taken 30 mg and I have no problems interacting with people "normally". I don't even use it especially often, but it seems my mind has accustomized to it and I need bigger doses to really "trip", even though there is no physical tolerance. It seems like a mental tolerance.