bluemorning
Bluelighter
- Joined
- Feb 12, 2009
- Messages
- 113
With opiates, the drug sticks to opiod receptors in your brain. Because they are an antagonist not an agonist, they dont really do anything, they just block other signals from your body from reaching the appropriate brain cell. Most cases these are unplesent signals, such as pain, hence why it makes such a good pain killer, the pain signal cant reach the brain cell it is supposed to. When you do a higher then average dose, your body realizes that the signals are being blocked and your brain actually produces more opiate receptors so the signals can get through. Now when the opiate wares off, not only can the signals start getting through again, there is more places from them to go, making you extra sensitive to all the bad shit the opiate was blocking. This is also what causes some of the withdrawl symptoms like sensitivity to pain when you quit, your body winds up with way too many opiod receptors so anything bad pretty much has a free open ride to do its nasyness.
I dont think there is anything you can really do to prevent these "hangovers", but a morning pill will block off those newly developed opiod receptors and you will feel all better again.
Im no bio-chemist, so i cant guarentee that what i said is correct, but from my understanding of how opiates work and the research i have done on the subject, this seems to be the most likely cause of these "opiate" hangovers. But remeber just cause it makes sense to me it doesnt mean its true.
Anyone have a different explaination id love to hear it
most opiates, at least the ones people take for fun, like oxy, morphine, heroin, etc. are agonists, not antagonists. they DO do something, and they don't just block pain signals by filling the receptor. antagonists are things like Naloxone (Narcan) which sit in the receptors and block other things (i.e. other opiate AGONISTS) from filling them.
I'm no bio-chemist either, so I can't tell you exactly what they do once they're logged in your mu-receptors...
The bit about creating more receptors seems more or less accurate , though.