Psychedelics/Dissociatives/MDxx
1. MXE (the high-quality white crystalline batch that was easily accesible a few years ago) > Ketamine (Racemic or S-Ket, both have their perks). Some would hate on the fact that I prefer K's better analogue, but it's ~2x the potency and duration, and other than it's warm opioid-esque dissociation, it goes much deeper in terms of psychedelia at M-hole doses (heavenly rush into a hole when IV'd)
2. LSD-25 (achieved some of the most meditative, transcendent states of bliss as well as healing introspective reflection or deep conversations/magical, telepathic energy with trip-buddies that builds the strongest of friendships. Visuals and mindgasms/body-highs/rushes that are pure magic)
2 II. DMT (certainly deserves it's place on this list, I'm sure I'd dig Ayahausca even more when I get the chance to try it due to the duration and more time to take in the wisdom)
3. MDMA/MDA, but MDA > MDMA (esp when taken together, MDA adds a colorful psychedelia and increases the orgasmic, tactile body-high to the warm, euphoric empathy)
4. Mushrooms (The ultra-potent P. Cubensis Thai strain, 1.5g's has put me in some deep, deep trips and the exotic, heavy-in-baeocystin/norbaeocystin P. Azurescens the most reminiscent of DMT, especially in the visuals and intensity, but it becomes very euphoric, free-spirited alongside a gentle tryptamine-sedation as the hypnotic visuals mesmerize)
5. Of course, Cannabis the perfect for everything/combine with anything psychoactive herb. Has a unique psychedelia as well as stimulating, sedating, creative/though-provoking/introspective, analgesic, healing and antidepressant properties; balanced perfectly in many hybrids or aiming for more of one/or some specific qualities there's pure Sativa and pure Indica strains. Not to mention edibles produce 11-OH-THC, which has given me some of the most euphoric highs ever obtained. Also potentiates the fuck out of dissociatives, opioids, psychedelics and synergizes with GABAergics and some stimulants.
I have yet to try Mescaline, otherwise I'm sure that would be up there alongside Ibogaine, DPT, 5-MeO-DMT, 5-MeO-MiPT, 2C-x's, and 3-MeO-PCP/2'-Oxo-PCE/3-MeO-PCE/PCP. Runner up: 4-AcO-DMT should be on this list. Dreamy and psilocin (psilocin sedation was definitely there, very warm and cozy) analogue with plenty of eye-candy and MDMA-like orgasmic, tactile body-high. I've heard 5-MeO-MiPT might have it beat in the body-high aspect.
I don't care to list the hedonistic drugs that ruin my life, although I will make an exception for: 1. Oxymorphone 2. Temazepam 3. Diazepam or Etizolam 4. Morphine/Diamorphine/Opium 5. D-Amphetamine via Dexedrine or even it's pro-drug lisdexamfetamine > d-Methamphetamine (too long of a duration, excess residual stimulation that is annoying, and a comedown that sucks; plus batches of crystal vary too much, I'd much rather obtain Desoxyn (pharm-grade d-methamp hcl prescribed in 5mg tablets). Oh yeah, one weird one I love is methadone + diazepam/clonazepam + cannabis. I love the NMDA-antagonist/MOR induced analgesia, long-duration and peak, and the nod is mad cozy and warm.