Dondante, when you say aE-DOM do you mean ARIADNE from Pihkal? Or do you mean something with an a-ethyl and an a-methyl? ARIADNE or aE-2CD is already described as an antidepressant. My thought is that the aE-2CB, aE-2CI, and aE-2CE might be more potent as psychedelics than aE-2CD and therefore interesting. Although this could just as well be a dead-end.
Has Helios at least verified the "anti-depressant" properties of ARIADNE?
There's probably a long list of 2,4,6 compounds that have yet to be experimented with too. I kind of see two approaches thought on this thread:
1. Which chemicals in the literature (Shulgin, Nicols, etc.) appear worthy of additional attention? Stuff like MEM and the Mescaline analogs fall into this catagory.
2. What kinds of novel and untested compounds appear worthy of synthesis and exploration?
So far most of what has appeared "on the scene", at least as far as psychedelics are concerned has been in category #1. This work has certainly been insightful in that many find compounds like 2C-C, DOC, 4-HO-MIPT to be quite therapeutically valuable.
As far as category #2 is concerned, this is an area that is likely to involve more effort with fewer "rewards". For each new possibility, someone has to devise a synthesis which can often involve multiple instances of trial and error. This person needs a reasonably extensive knowledge of chemistry and access to analytical equipment to verify the identity and purity of the product. Then of course, the chemical must be assayed for activity, possibly by an animal first and then by a human. This is a hit or miss thing. Most of the suggestions in this thread including my own will probably be inactive.
This actually leads me to greater question about our roles as researchers. The primary goal of this board is to be a harm reduction forum. Clearly, there's much more going on here than that and I've noticed there are some very educated people who are participating. Perhaps I should collect my thoughts and share them in greater detail in a new thread.
Has Helios at least verified the "anti-depressant" properties of ARIADNE?
There's probably a long list of 2,4,6 compounds that have yet to be experimented with too. I kind of see two approaches thought on this thread:
1. Which chemicals in the literature (Shulgin, Nicols, etc.) appear worthy of additional attention? Stuff like MEM and the Mescaline analogs fall into this catagory.
2. What kinds of novel and untested compounds appear worthy of synthesis and exploration?
So far most of what has appeared "on the scene", at least as far as psychedelics are concerned has been in category #1. This work has certainly been insightful in that many find compounds like 2C-C, DOC, 4-HO-MIPT to be quite therapeutically valuable.
As far as category #2 is concerned, this is an area that is likely to involve more effort with fewer "rewards". For each new possibility, someone has to devise a synthesis which can often involve multiple instances of trial and error. This person needs a reasonably extensive knowledge of chemistry and access to analytical equipment to verify the identity and purity of the product. Then of course, the chemical must be assayed for activity, possibly by an animal first and then by a human. This is a hit or miss thing. Most of the suggestions in this thread including my own will probably be inactive.
This actually leads me to greater question about our roles as researchers. The primary goal of this board is to be a harm reduction forum. Clearly, there's much more going on here than that and I've noticed there are some very educated people who are participating. Perhaps I should collect my thoughts and share them in greater detail in a new thread.
