e1evene1even - thanks for the published studies. This is so frustrating, because I do have a chronic illness in addition to depression, and there is published research back to the mid-eighties that NMDA antagonists and opiates help with pain and depression/bipolar, but researchers don't offer treatment, and on the treatment end, doctors just don't want to know. They want me to suffer in silence and be compliant. Then you are labeled a drug user if you take your illness into your own hands, do your homework, get your own medications and self-treat (to life-changing success, I might add).