Well one one hand I function best whilst on oxy+morphine (rx), because without opioids I quite simply wouldn't even be able to walk to the lab without using upper body strength alone to drag myself up the stairs, nerve damage in one leg, after an operation to remove bone fragments that had been tearing the joint a new set of arses, fell on an upwards-pointing spike of glass as a kid, had to snap it off and drag myself several miles home to get an ambulance, and in recovery after the main bit of glass that went through my patellar tendon, I got jumped by way more pikey tossers than even I had enough CW agents handy to,,,discourage,,,got my head stamped on, same with my kneecaps, been crippled as a result ever since,
As for suppers, never found them reinforcing much. Amphetamines I've found useful for times I HAVE to concentrate on a task (btw, you know who, sorry about the delay, had to wait for some borohydride to get here) and for if I've reached my limits and have to go beyond what a man can naturally go, then they are useful, otherwise I only take them for final quality control; I enjoy the chemistry far more than I ever have the product;
It can't go anywhere without testing though, so I have to take amphetamines at some point, I'll enjoy it as far as is possible for me, but there is a limit and its fairly low, I am already too high-strung being autie. But quality control is a must, nothing can leave without personal bioassay so it has to be done whether I like it or not.
Responsible? with uppers, yes, very, I have to force myself to use a proportion of my own batches to make sure there is nothing wrong, opioids, I'm only walking because of the damn things. Its dissociatives I'm going to be irresponsible with. the veins that are accessible after my former housemate tried to carve me up with her katana and after the willy pete burns and one from mixed nitrating acid, there aren't that many left, even after ultranonography, its hard for an anaesthatist to find a vein, the likes of MXE and 3-OH-PCP, I totally fucked all but perhaps two veins I can find, going through 10g+MXE IV in perhaps 3-4 days, sometimes twice that, Something about NMDA antagonists levels me out. I've been fighting for years to get a memantine rx, that clears up so much shit it's the difference between night and day, but psychedelic/dissociative NMDAr antagonists, I can't help but go at it hell for leather.