Mental Health Meth To Treat ADHD?

I have some thoughts, respectfully.

So no one is recovering from strokes., as far as I'm concerned. And increased glutamatergic connection doesn't equal increased brain health in a vacuum. No one is arguing that amphetamines can't increase memory. Add in addictive properties/neurotoxic potential at over 25mg oral, and you have a bad idea, imho...
 
@dextroisomer no worries. Just misunderstandings and me feeling a bit ranty.

Back on the subject of meth and ADHD. I have ADHD and generally 30 mg dexamfetamine split into 3x10 mg doses through the day totally clears up all my symptoms and turns me into a highly productive ‘knowledge worker’ capable of reading all the books and articles I need to and writing reams of quality text. The difference in my academic productivity before and after dexamfetamine almost can’t even be compared the difference is so great. I flunked undergrad before diagnosis but won half a dozen prizes and scholarships in postgrad after diagnosis.

Despite having a couple of years experience with meth, I don’t think I’ve ever managed to do even an hour’s work on it. Even smoking just a half point worsens all my ADHD symptoms. The funny thing is though that it makes me feel way more intelligent and I’ll often have a whole bunch of half-insights and half-thoughts about my work - but totally incapable of fully forming them and writing them down.

After a meth binge, even after the first good night’s sleep after I stop smoking, my mind feels like my ADHD has been ramped up by a factor of 100 at least. On those days I sometimes take my whole dexamfetamine doses at once about 11 AM together 4 shots of strong espresso coffee and end up being able to do maybe 2 or 3 hour of work that requires a bit of thinking but nothing critical.
 
I’ve also have had many drug world associates who live in public/welfare housing. Just the other day I visited one who had enough meth in his government provided apartment to buy a waterfront mansion in Sydney’s best suburbs and maybe get a yacht to park in front of it. But every week he’s down the dole office making sure he gets that $200.

Sounds you're describing my old Australian friend Crash, a bit of a bogan, but i hear he's making a name for himself down in Sydney:

Here's a picture of him:

 
Sounds you're describing my old Australian friend Crash, a bit of a bogan, but i hear he's making a name for himself down in Sydney:

Here's a picture of him:

You’d be surprised (or maybe not) by just how many times I’ve sat in public housing living rooms with blokes just like this sociably smoking whatever crush is left at the bottom of someone’s bag as we wait interminably for “the bloke” to turn up any minute and sort us all out.
 
Lol. You would really hate an old room mate of mine. I think I actually told you once how I caused him to relapse due to him constantly leaving shit stains on the toilet seat. Well, that wasn't the only reason but it was the final straw. He's on social assistance and gets weekly grocery vouchers which he pawns for crack and weed. Mostly crack. This leads to him never having food. So he goes around the shitty bed bug infested hotel he lives in asking people for food. He's begged me multiple times and I always tell him to pound sand.

When nobody gives him anything he just goes to the hospital via ambulance. I actually saw him there last night. There was this trolley of half eaten sandwhiches near his room, he goes up to it and starts stuffing them into his mouth. After he was done, he's like "I feel better can I go home now"

Another interesting tidbit, I used to live just a few doors down from him in said shitty hotel. One night I noticed a heavy police presence in and around his room. 2 in the hallway were laughing and joking about how messy and stinky his room was. 2 more were actually inside complaining about it. As they were leaving with him in cuffs, one of them said his room smelled like.......you guessed it......semen.

So yeah, total loser.
Don’t get me wrong - I have real compassion for people who are by nature or accident are rendered unable to support themselves. I don’t mind my taxes helping them enjoy a decent life and i’ll open my wallet on the spot if I can genuinely help someone make a move upwards.

It’s the fuckers that could contribute to society - or at least earn enough to pay their own way - and refuse to that piss me off.

Although I sometimes laugh in spite of myself just how much real effort some people I know put into scamming the system to avoid working. If they put half that ingenuity and effort into an entry level job somewhere they’d be the CEO inside a year and probably still have more free time.
 
I have some thoughts, respectfully.
Sure thing. Absolutely. That's what this place is all about 👍
So no one is recovering from strokes., as far as I'm concerned.
No. Not yet at least. Phase I human trials have been completed and phase IIa dose escalation studies are moving forward (I'm not going to pretend like I know what any of that means, because I don't. But it does sound promising):
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And increased glutamatergic connection doesn't equal increased brain health in a vacuum.
Lost here, can you explain? I'm no Neuroscientist, although I'm trying my absolute best to become one, and I did sleep at a Holiday-Inn Express last night :)
Add in addictive properties/neurotoxic potential at over 25mg oral, and you have a bad idea, imho...
Now this statement, this statement I have to challenge. I've done quite a bit of research, quite a bit. Wouldn't it be fair to say Methamphetamine's Neurotoxicity threshold is anything above 50mg? I mean, 25mg? A little low-bar, no? Or maybe it's best to air on the conservative side of things?
 
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Lol. You would really hate an old room mate of mine. I think I actually told you once how I caused him to relapse due to him constantly leaving shit stains on the toilet seat. Well, that wasn't the only reason but it was the final straw. He's on social assistance and gets weekly grocery vouchers which he pawns for crack and weed. Mostly crack. This leads to him never having food. So he goes around the shitty bed bug infested hotel he lives in asking people for food. He's begged me multiple times and I always tell him to pound sand.

When nobody gives him anything he just goes to the hospital via ambulance. I actually saw him there last night. There was this trolley of half eaten sandwhiches near his room, he goes up to it and starts stuffing them into his mouth. After he was done, he's like "I feel better can I go home now"

He's also watched people OD on fentanyl and just walk away without trying to help.

So yeah, total loser.
What the flippin’ fuck that’s so friggin bad, like shiiiiit.
 
Please read that out loud and explain to me how a doctor will see that as anything other than drug-seeking.
The correct way to do this would be to explain that your Dexedrine, Adderal, and Vyvanse prescriptions did not work and made you feel like shit.
Say that you want to try something else and that you heard online about something called 'Desoxyn' and ask if your doctor has heard of it.
There's a good chance that it won't work, and I again do not recommend going down this road, but it's better than the way you are planning on asking.
How would you go about asking adhd psychiatrist for desoxyn, not prescribed in Aust. I contacted company that would supply if prescribed by dr, off label etc.
I don’t hold much hope, have been self medicating for 10 years on & off undiagnosed adhd, smoked at first, went to goal 6months, successful career, BA Arts, mum. Last 4 years orally 30mg in morning, maybe top up at lunch, never any after midday. Nobody knows. Since informal adhd diagnosis 8 months ago, stopped. Fucking hate it, have assessment Monday. My psychologist supportive desoxyn.
psychedelic assisted therapy 2 weeks
Maybe fuck off stims all together and microcode shrooms or lsd?
 
How would you go about asking adhd psychiatrist for desoxyn, not prescribed in Aust. I contacted company that would supply if prescribed by dr, off label etc.
I don’t hold much hope, have been self medicating for 10 years on & off undiagnosed adhd, smoked at first, went to goal 6months, successful career, BA Arts, mum. Last 4 years orally 30mg in morning, maybe top up at lunch, never any after midday. Nobody knows. Since informal adhd diagnosis 8 months ago, stopped. Fucking hate it, have assessment Monday. My psychologist supportive desoxyn.
psychedelic assisted therapy 2 weeks
Maybe fuck off stims all together and microcode shrooms or lsd?

Sorry no-one has responded to this sooner. Your story is extremely common in Australia for adult men with undiagnosed ADHD. I read a study once that a very high proportion of first-time offenders entering gaol in Australia were undiagnosed at the time of their offence, or else mis-diagnosed as having bi-polar or some other disorder.

I don’t think asking your psychiatrist directly for Desoxyn (meth) or even any stimulant is the right strategy.

Currently in Australia stimulants are officially the first-line treatment for ADHD. So if your Psychiatrist believes you have it then he’s going to recommend stimulants at some point anyway even if you don’t mention them.

Psychiatrists will prescribe stimulants to ADHD patients with a history of stimulant and other drug addiction. This is because Psychiatrists acknowledge that self-medication with illegal drugs, especially stimulants, is a legitimate and very common symptom of untreated ADHD.

I was diagnosed with ADHD at about age 45 and had been using speed and cocaine on and off my entire life. I was also only 3 months clean from a 6 month IV meth binge (my first experience with meth).

As an addict it worked like this:

1. First psychiatrist gave diagnosis and required 3 months drug free (tested only once) to agree to treat me

2. He offered non-stim med Strattera first but it triggered mania in me. To prescribe stimulants to an ex-addict he was required by law to get a second opinion from another psychiatrist. He sent me to his mate next door amd $300 later I had that.

3. He tried Ritalin first but it made me very jittery so he then tried Dexamfetamine which I found worked perfectly. It took about 3 months to work out the right dose and he was happy to get the special permission to give me more than the max allowed 30 mg a day, but in the end that was enough.

4. I still had cravings for meth and coke for a while but a new psychiatrist added the anti-psychotic Abilify to what I was taking. After that I had no drug cravings of any kind and was basically sober with no ADHD symptoms for the next 5 years.

5. During those 5 years my life was damn near perfect in terms of work and relationships and I had probably never been happier.

So basically my advice is get a referral to a Psychiatrist that specialises in adult ADHD - Google will find one in your area no problem. Try and be totally clean for at least 1 month before you see him, tell him you suspect ADHD (your GP referral should also state this) and want to be tested and know your treatment options (don’t mention stims yet), be honest about your drug history but be clear you are an ex addict and not current user.

If for some reason he does not mention stims as an option ask him why since it is common knowledge they are the main treatment and whether it is because of your drug history. If he says yes, say you know other ex addicts who successfully used prescribed stimulants without relapsing or abuaing them and could he recommend a colleague for a second opinion.

If he wants you to try Stratterra first you should. It might even work and if it doesn’t it proves you are serious about finding the best treatment.
 
I can't speak for meth as a treatment for ADHD, but I can say that I have had a number of friends who didn't do well with standard ADHD prescriptions, i.e., Ritalin, Adderal, Vyvanse, Straterra, etc., but they did experience good results with Concerta. I don't know how Concerta differs from the aforementioned drugs, just that friends have seemed to prefer this drug to others, and I hadn't seen it mentioned above.
I do quite well with my 40mg of Vyvanse, and I don't anticipate any changes to this dosage.
 
I can't speak for meth as a treatment for ADHD, but I can say that I have had a number of friends who didn't do well with standard ADHD prescriptions, i.e., Ritalin, Adderal, Vyvanse, Straterra, etc., but they did experience good results with Concerta. I don't know how Concerta differs from the aforementioned drugs, just that friends have seemed to prefer this drug to others, and I hadn't seen it mentioned above.
I do quite well with my 40mg of Vyvanse, and I don't anticipate any changes to this dosage.
Concerta and Ritalin are different brand names for the same drug: methylphenidate hydrochloride.

It is a stimulant but not an amphetamine. ADHD is a diagnosos that encompasses many different possible sytemic dysfunctions in the brain. The dysfunctions can relate primarily to a specific neurotransmitter (primarily dopamine but reserxh shows serotonin, opioid, glutamate, and acetylcholine receptors are also involved for many patients) or to a specific region of the brain and/or some combination thereof.

Different stimulants and other drugs impact different neurotransmitters and different regions of the brain in different ways. In the US Adderall is popular with doctors because as a combination of 4 different amphetamine salts it works like a scattergun impacting the widest possible combination of transmitters/regions thus making it more likely to be effective for any given patient regardless of the specifics of their neurological dysfunction.

In Australia it has been found that the majority of patients respond to one or another of the single type stimulants like methylphenidate or dexamfetamine and a person who does not reapond well to one will likely respond well to the other.

One important difference between the two is that methylphenidte is serotonergically active as well as dopaminergic. Hypothetically, this might make it more agreeable to someone who finds that meth relieves their symptoms since meth is also somewhat serotonergic whereas amphetamine is not.

Although, contra that hypothesis I loved meth but could not tolerate methylphenidate as it made me very jittery. But then even tiny doses of meth worsen my ADHD symptoms while relatively low doses of amphetamine almost clean them up entirely.

The choice of one over the other can also be influenced by the patient’s co-morbid psychiatric problems - such as depression or amxiety - and any medication for them. For example, having bi-polar I could not even trial Strattera because of the high propensity it has to induce mania in BPD patients.

In general, the primary effect of both amphetamine and methylphenidate is to increase central dopamine and norepinephrine activity, which impacts executive and attentional function. Amphetamine actions include dopamine and norepinephrine transporter inhibition, vesicular monoamine transporter 2 (VMAT-2) inhibition, and monoamine oxidase activity inhibition. Methylphenidate actions include dopamine and norepinephrine transporter inhibition, agonist activity at the serotonin type 1A receptor, and redistribution of the VMAT-2.
 
One important difference between the two is that methylphenidte is serotonergically active as well as dopaminergic. Hypothetically, this might make it more agreeable to someone who finds that meth relieves their symptoms since meth is also somewhat serotonergic whereas amphetamine is not.
Hey there, I have always heard that methylphenidate is a pretty strict ndri? Do you have any sources that it is serotonergic, if so that really changes my paradigm of viewing that drug.
I know wiki is lazy, but it demonstrates negligable SERT affinity.

 
I
Hey there, I have always heard that methylphenidate is a pretty strict ndri? Do you have any sources that it is serotonergic, if so that really changes my paradigm of viewing that drug.
I know wiki is lazy, but it demonstrates negligable SERT affinity.

i have read some animal studies focussed on it being an agonist 5ht1a only in the nucleus acumbens which in turn results in dysregulation of the dopamine reward pathway but also dose-dependent improvements in cognition - primarily memory.

There is a general mention of it being a 1a agonist in humans in this paper which I re-read quickly for the purposes of fact-checking the original post I made above: https://www.sciencedirect.com/science/article/pii/S0149763417308072

So it seems most correct to say it is serotonergic only in certain regions of the brain. Not universally so. And that this is part of the cascade process through which it causes subsequent activity in certain parts of the dopamine system.

We can’t really talk about just dopamine or just serotonin generically in this context - it is so region specific within the brain.
 
I couldnt recomend any type of speed - you start off thinking its great then it slowly sends you utterly insane.
 
Wait a minute. Hasn't this experiment or course of action already been tried?

Clinical trial started here:


Led to this:


Unfortunately the grand finale thread is no longer and has been deleted.

So is this a viable and credible treatment? Read those threads carefully and in order and you be the judge (OP).
 
Wait a minute. Hasn't this experiment or course of action already been tried?

Clinical trial started here:


Led to this:


Unfortunately the grand finale thread is no longer and has been deleted.

So is this a viable and credible treatment? Read those threads carefully and in order and you be the judge (OP).
Street Meth = Never Again

Who knows what they’re putting in that shit anymore. Who knows? Who knows if it’s even Meth?

That said, I’d really REALLY like to give Desoxyn a try someday down the road, just to see how it compares. But as far as street meth goes? Never again. It worked great at first, it worked phenomenal at first, but then (for whatever reason) it gradually began to drive me insane. Who knows what they’re putting in it, who knows…
 
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I couldnt recomend any type of speed - you start off thinking its great then it slowly sends you utterly insane.
Do you include prescribed stimulants taken at prescribed dosage levels in this claim?

Even though stimulants were historically connected to treating ADHD in a pretty slipshod way with little research or risk analysis it seems that millions of people, especially kids, have been able to use them to successfully ameliorate ADHD symptoms without any great drama and in many cases to eventually grow out of the need to keep taking them.

I tend to agree with my psychiatrist (who basically only treats adult ADHD) when he says that people misdiagnosed with ADHD can develop problems abusing prescribed stimulants and often then moving on to illicit street drugs. However, I also believe him when he says that for most people with genuine ADHD that responds to low dose stimulants, there is no increase in tolerance over time (specifically with respect to what dose is required to ameliorate the ADHD and minimal risk of addiction.

He says most of his adult patients never increase their dose once the ideal dose is titrated even if they need to continue treatment for a decade or more. Certainly, in my experience the same 30 mg dose of dexamfetamine per day decreased my ADHD symptoms by exactly the same degree for 5 years. And I often discontinued the dose on weekends or holidays for several days and never once felt any kind of comedown, withdrawal or craving even though I felt my ADHD symptoms return within a day or two of stopping the dexamfetamine.

I also felt a reduction in desire or interest in everything from caffeine to alcohol to LSD while being treated for ADHD. If it hadn’t been for experiencing meth during a difficult personal period I expect I’d still just be doing my 30 mg dex daily and leading a super productive and happy life otherwise free of substance ab/use.
 
Concerta and Ritalin are different brand names for the same drug: methylphenidate hydrochloride.

It is a stimulant but not an amphetamine. ADHD is a diagnosos that encompasses many different possible sytemic dysfunctions in the brain. The dysfunctions can relate primarily to a specific neurotransmitter (primarily dopamine but reserxh shows serotonin, opioid, glutamate, and acetylcholine receptors are also involved for many patients) or to a specific region of the brain and/or some combination thereof.

Different stimulants and other drugs impact different neurotransmitters and different regions of the brain in different ways. In the US Adderall is popular with doctors because as a combination of 4 different amphetamine salts it works like a scattergun impacting the widest possible combination of transmitters/regions thus making it more likely to be effective for any given patient regardless of the specifics of their neurological dysfunction.

In Australia it has been found that the majority of patients respond to one or another of the single type stimulants like methylphenidate or dexamfetamine and a person who does not reapond well to one will likely respond well to the other.

One important difference between the two is that methylphenidte is serotonergically active as well as dopaminergic. Hypothetically, this might make it more agreeable to someone who finds that meth relieves their symptoms since meth is also somewhat serotonergic whereas amphetamine is not.

Although, contra that hypothesis I loved meth but could not tolerate methylphenidate as it made me very jittery. But then even tiny doses of meth worsen my ADHD symptoms while relatively low doses of amphetamine almost clean them up entirely.

The choice of one over the other can also be influenced by the patient’s co-morbid psychiatric problems - such as depression or amxiety - and any medication for them. For example, having bi-polar I could not even trial Strattera because of the high propensity it has to induce mania in BPD patients.

In general, the primary effect of both amphetamine and methylphenidate is to increase central dopamine and norepinephrine activity, which impacts executive and attentional function. Amphetamine actions include dopamine and norepinephrine transporter inhibition, vesicular monoamine transporter 2 (VMAT-2) inhibition, and monoamine oxidase activity inhibition. Methylphenidate actions include dopamine and norepinephrine transporter inhibition, agonist activity at the serotonin type 1A receptor, and redistribution of the VMAT-2.
 
Concerta and Ritalin are different brand names for the same drug: methylphenidate hydrochloride.

It is a stimulant but not an amphetamine. ADHD is a diagnosos that encompasses many different possible sytemic dysfunctions in the brain. The dysfunctions can relate primarily to a specific neurotransmitter (primarily dopamine but reserxh shows serotonin, opioid, glutamate, and acetylcholine receptors are also involved for many patients) or to a specific region of the brain and/or some combination thereof.

Different stimulants and other drugs impact different neurotransmitters and different regions of the brain in different ways. In the US Adderall is popular with doctors because as a combination of 4 different amphetamine salts it works like a scattergun impacting the widest possible combination of transmitters/regions thus making it more likely to be effective for any given patient regardless of the specifics of their neurological dysfunction.

In Australia it has been found that the majority of patients respond to one or another of the single type stimulants like methylphenidate or dexamfetamine and a person who does not reapond well to one will likely respond well to the other.

One important difference between the two is that methylphenidte is serotonergically active as well as dopaminergic. Hypothetically, this might make it more agreeable to someone who finds that meth relieves their symptoms since meth is also somewhat serotonergic whereas amphetamine is not.

Although, contra that hypothesis I loved meth but could not tolerate methylphenidate as it made me very jittery. But then even tiny doses of meth worsen my ADHD symptoms while relatively low doses of amphetamine almost clean them up entirely.

The choice of one over the other can also be influenced by the patient’s co-morbid psychiatric problems - such as depression or amxiety - and any medication for them. For example, having bi-polar I could not even trial Strattera because of the high propensity it has to induce mania in BPD patients.

In general, the primary effect of both amphetamine and methylphenidate is to increase central dopamine and norepinephrine activity, which impacts executive and attentional function. Amphetamine actions include dopamine and norepinephrine transporter inhibition, vesicular monoamine transporter 2 (VMAT-2) inhibition, and monoamine oxidase activity inhibition. Methylphenidate actions include dopamine and norepinephrine transporter inhibition, agonist activity at the serotonin type 1A receptor, and redistribution of the VMAT-2.
Your knowledge is awesome! Obviously you studied science?
 
Your knowledge is awesome! Obviously you studied science?
Not really. I just took a lot of interest in what was wrong with me and read everything I could. I learned a lot here on Bluelight too in the Neuroscience and Pharmacology forum where we have a lot of proper qualified scientists discussing stuff. But also a lot of serious amateurs interested in how drugs work.
 
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