I hope people don't mind me bringing up this thread as it hasn't been active for a while but I have searched and have not been able to find an answer to the question that is concerning me.
I have been an opioid user for over 20 years and on the methadone for 17 so obviously my tolerance is pretty high.
I really like morphine as I find it plays much better with my methadone than heroin does for whatever reason.
I do not inject anymore so of coarse I am faced with the problem of needing rather large amounts of morphine to have a worthwhile effect when taking it orally and after doing research I thought plugging may be the answer.
I read tricombs instructions and followed his protocol precisely except I did not adjust the ph of my mixture.
I found a very good study regarding extracting morphine from ms contin and after reading it I have a couple of questions.
Firstly the authors of this study do not seem to think it is necessary to let the mixture stand for any length of time, here is a quote from the study.
Morphine in the ms contin brand of time release tablets is embedded in a complex dual matrix of hydroxyethyl cellulose and cetostearyl alcohol designed to release the drug over a 12 hour period, crushing the tablet disrupts this matrix allowing the rapid extraction of morphine.
I am not trying to start an argument about whether or not you do have to wait or not, I myself do let it sit as I follow tricombs protocol, I am just stating what is in the article.
The question that I am really concerned about is regarding adjusting the ph of the solution.
I read the link to the pubmed article that says raising the ph of the solution improves the absorbtion of rectaly administered morphine so I intended on doing exactly that until I read this in the study I found.
The aqueous solubility of morphine is critically dependent on its ionization and therefor the ph.
The authors quote figures of about 13mg/ml at a ph of 6 and 5mg/ml at a ph of 6.5 so I am thinking at a ph of around 8 which is what tricomb recommends it would be almost insoluble.
My knowledge of chemistry is only very basic so I am sure I may just be confusing myself here but it would be great if someone more knowledgeable could help me out here.
I have only plugged once so far and got quite a good result from 100mg of morphine sulphate, if I get a drastic improvement from raising the ph of the solution as tricombs link states I think I could get very good results without resorting to huge doses, I am concerned however that if I do raise the ph the morphine would come out of solution.
Here is the article I refer to.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803777/
Sorry if this post is a bit long winded