This is a really, really, stupid post, because simply mixing loperamide and your supposed nanoparticles isn't going to properly coat them. You're trying to coat really, really, tiny bits- not big lumps.
And this is something you should really be testing on yourself first.
"Scientific Reporting" isn't writing up something you think is going to work. It's actually trying it and then reporting it. What you're 'reporting' isn't scientific either. All it is, is a theory that hasn't been subject to any scrutiny and isn't likely to work.
And more, I have to question why anyone would even want loperamide to get into the brain. It's a pretty toxic drug. Too close to MPTP, for me.
Many reports of loperamide nanoparticles coated with polysorbate 80 being IVed give very good and safe results!
Actually, there are absolutely no reports of loperamide coated with PS80 outside of select academic situations. Loperamide is known as an analgesic, sure, but it's also known to produce tons of side effects even in academic settings. I'd hate to see what would happen if it were available to junkies like Heroin and Hydro is.
If you want see what loperamide is actually like, all you gotta do is take a P-glycoprotein inhibitor.