First Bad Comedown
Bluelighter
- Joined
- Nov 26, 2010
- Messages
- 562
Enema man here!
Yes - I have no doubt that MDMA damaged my intestines, not water.
And I have spoken with MANY people who experience digestive difficulties after psychedelic-induced neurotoxicity.
This includes MDMA, mushrooms, LSD, and pipes.
Two of my close friends had intestinal surgery within days of their last trip!
One had a stricture in the large intestine that wasn't removed and a bent section of small intestine that was - caused by regular psylosibin use.
And the other had an appendicitis 24 hours after his first mushroom/MDMA combo.
And then there are the countless examples in medicine that illustrate how the intestines are linked to psychological disorders.
IBS is an extreme example, with sufferers abusing medical resources in a desperate attempt to fix the problem.
Those who suffered sexual abuse, esp. females, have the greatest digestive malfunction.
Severe depression and psychotic disorders like schizophrenia are also associated with altered intestinal motility and fixation on bodily functions.
There are many more examples to be had, should you care to learn about the second nervous system in your gut.
And that is what makes MDMA worth doing in the first place.
The same neurotransmitter than contracts the intestines makes up the most dense and diverse neurotransmitter system in the brain.
It influences blood distribution, glucose consumption, dopamine transmission, neuronal firing...
And in all the brain functions that serotonin modulates, it is the direct controller of none!
The link between the brain and intestines is only beginning to be understood.
And some of the basic properties of this system have allowed pharmaceutical companies to profit BILLIONS of dollars off of SSRIs.
It really is incredible that targeting serotonin into the higher brain, particularly the PFC, causes such a DRAMATIC change in people that they will live YEARS on the medication. And doctor's are so impressed with the results that they keep prescribing them.
Laxguy - if you need evidence that MDMA use leads to cognitive changes, sometimes negative, simply check out the contributions of ChiLights to the following thread: http://www.bluelight.ru/vb/threads/...ong-term-side-effects?p=10137491#post10137491
This is the type of person I have to convince on BL.
Obviously some people are more than willing to tolerate the effects that they notice.
If you want more convincing reasons, check out my earliest posts.
Then look at Somedud, Catinthehat4, Bben, Altered Perception...
Just do a search for anxiety or 'brain zaps'.
You will find all the reasons you could possibly need.
If only you care to look.
My friend Folley is correct - repeated doses are known to cause greater damage.
While his 'brain raping' claims may not sound scientific....
And there are certainly many BL members, such as my newest ass fan ChiLights, that will contribute how much they have gotten away with doing....
The fact is that PLENTY of research shows that repeated doses is the most likely way to cause sudden and catastrophic damage to the brain's most intricate neurotransmitter system. If nothing else, primate research has proven that IF 'brain damage' is going to occur, it is MUCH more likely to happen if MDMA is used on consecutive days.
Even the ridiculous high doses they use in these studies, normally 20mg/kg or 12-18 avg. pills injected, do not cause severe toxicity the first night.
It is the exposure on day two, three, and four that causes MASSIVE degeneration of axons and terminals.
And humans are more sensitive to degeneration than primates.
From all the research I have read the 'safe' dose of MDMA is likely 1-2 avg pills taken no more than once every 90 days.
Some scientists believe that ALL doses produce some small level of axonal degeneration.
And cognitive studies of humans have indeed found mild deficits even in moderate MDMA users.
Meanwhile, these same users do not always display a loss of endocrine function or SERT density on neuroimaging scans.
These two findings may simply mean that our methods of detection fail to see the damage that is occurring.
And more precise imaging requires a dead brain!
Besides, there are many studies that DO show loss of SERT and endocrine function - even in MDMA users that have been abstinent for up to THREE years! So the 'methods of detection' are finding alarming results in a minority of users.
Anecdotal reports on BL will confirm that rolling two days in a row is a VERY bad idea.
The last person that bothered to poke fun at me, Master Splinter, ended up in complete agreement with me - ROLLING TWO DAYS IN A ROW IS RETARDED.
It is never as euphoric and jaw clenching and general shittiness is MUCH more pronounced.
I always said it felt like a rusty coin took a SHIT in my mouth.
The only bad comedowns I had were on the two occasions I rolled two days in a row.
The third time led to my screename and infamous presence on BL.
I also do NOT recommend taking the Adderall the night after MDMA.
Yes, this increases toxicity because serotonin is lower. Extra dopamine after MDMA is a shitty experience anyways - you won't like it.
Take the adderall the first night if you must, but in reasonable quantity. And get sleep.
Then roll the second day.
Then consider a SMALL dose of a 5HT2a agonist like mushrooms the next.
Ketamine, again in small dose, would also be ok.
But for god's sake, listen to the people around you.
The smart ones.
Only in this forum of etards could you actually find people willing to support a three day roll!
Plenty of mods in the past have issued strong warnings to posts like yours.
Just.
Don't.
Do it.
k?
Yes - I have no doubt that MDMA damaged my intestines, not water.
And I have spoken with MANY people who experience digestive difficulties after psychedelic-induced neurotoxicity.
This includes MDMA, mushrooms, LSD, and pipes.
Two of my close friends had intestinal surgery within days of their last trip!
One had a stricture in the large intestine that wasn't removed and a bent section of small intestine that was - caused by regular psylosibin use.
And the other had an appendicitis 24 hours after his first mushroom/MDMA combo.
And then there are the countless examples in medicine that illustrate how the intestines are linked to psychological disorders.
IBS is an extreme example, with sufferers abusing medical resources in a desperate attempt to fix the problem.
Those who suffered sexual abuse, esp. females, have the greatest digestive malfunction.
Severe depression and psychotic disorders like schizophrenia are also associated with altered intestinal motility and fixation on bodily functions.
There are many more examples to be had, should you care to learn about the second nervous system in your gut.
And that is what makes MDMA worth doing in the first place.
The same neurotransmitter than contracts the intestines makes up the most dense and diverse neurotransmitter system in the brain.
It influences blood distribution, glucose consumption, dopamine transmission, neuronal firing...
And in all the brain functions that serotonin modulates, it is the direct controller of none!
The link between the brain and intestines is only beginning to be understood.
And some of the basic properties of this system have allowed pharmaceutical companies to profit BILLIONS of dollars off of SSRIs.
It really is incredible that targeting serotonin into the higher brain, particularly the PFC, causes such a DRAMATIC change in people that they will live YEARS on the medication. And doctor's are so impressed with the results that they keep prescribing them.
Laxguy - if you need evidence that MDMA use leads to cognitive changes, sometimes negative, simply check out the contributions of ChiLights to the following thread: http://www.bluelight.ru/vb/threads/...ong-term-side-effects?p=10137491#post10137491
This is the type of person I have to convince on BL.
Obviously some people are more than willing to tolerate the effects that they notice.
If you want more convincing reasons, check out my earliest posts.
Then look at Somedud, Catinthehat4, Bben, Altered Perception...
Just do a search for anxiety or 'brain zaps'.
You will find all the reasons you could possibly need.
If only you care to look.
My friend Folley is correct - repeated doses are known to cause greater damage.
While his 'brain raping' claims may not sound scientific....
And there are certainly many BL members, such as my newest ass fan ChiLights, that will contribute how much they have gotten away with doing....
The fact is that PLENTY of research shows that repeated doses is the most likely way to cause sudden and catastrophic damage to the brain's most intricate neurotransmitter system. If nothing else, primate research has proven that IF 'brain damage' is going to occur, it is MUCH more likely to happen if MDMA is used on consecutive days.
Even the ridiculous high doses they use in these studies, normally 20mg/kg or 12-18 avg. pills injected, do not cause severe toxicity the first night.
It is the exposure on day two, three, and four that causes MASSIVE degeneration of axons and terminals.
And humans are more sensitive to degeneration than primates.
From all the research I have read the 'safe' dose of MDMA is likely 1-2 avg pills taken no more than once every 90 days.
Some scientists believe that ALL doses produce some small level of axonal degeneration.
And cognitive studies of humans have indeed found mild deficits even in moderate MDMA users.
Meanwhile, these same users do not always display a loss of endocrine function or SERT density on neuroimaging scans.
These two findings may simply mean that our methods of detection fail to see the damage that is occurring.
And more precise imaging requires a dead brain!
Besides, there are many studies that DO show loss of SERT and endocrine function - even in MDMA users that have been abstinent for up to THREE years! So the 'methods of detection' are finding alarming results in a minority of users.
Anecdotal reports on BL will confirm that rolling two days in a row is a VERY bad idea.
The last person that bothered to poke fun at me, Master Splinter, ended up in complete agreement with me - ROLLING TWO DAYS IN A ROW IS RETARDED.
It is never as euphoric and jaw clenching and general shittiness is MUCH more pronounced.
I always said it felt like a rusty coin took a SHIT in my mouth.
The only bad comedowns I had were on the two occasions I rolled two days in a row.
The third time led to my screename and infamous presence on BL.
I also do NOT recommend taking the Adderall the night after MDMA.
Yes, this increases toxicity because serotonin is lower. Extra dopamine after MDMA is a shitty experience anyways - you won't like it.
Take the adderall the first night if you must, but in reasonable quantity. And get sleep.
Then roll the second day.
Then consider a SMALL dose of a 5HT2a agonist like mushrooms the next.
Ketamine, again in small dose, would also be ok.
But for god's sake, listen to the people around you.
The smart ones.
Only in this forum of etards could you actually find people willing to support a three day roll!
Plenty of mods in the past have issued strong warnings to posts like yours.
Just.
Don't.
Do it.
k?
