Many OC users like to snort their dose. I really hope this is circumvented somehow, because while OC is great orally, it is IMO just not quite as good as snorting. Snorting OC is, in my opinion, better than pretty much any other drug by any ROA. I will not be too pleased if this ROA is taken away from me.
You may ask why I am so focused on the snorting aspect, and it is because I think a huge percentage of people who use OC off-label snort it. When used IV, oxycodone is generally accepted to be not overwhelmingly great. Oral dosage absorbs more, but it is much slower to the max plasma concentration and that created a drastic shift in effects. I feel you have to take a good bit more OC orally to get the effects of the same dose snorted, only the effects would last a good bit longer.
I think if I got one of these now, I'd crush it as well as I possibly could and swallow little bits of the powder at a time, so that it is not gelling together in a lump when it hits the liquid in your mouth/ throat/ stomach. Until an effective way of making these snortable is found, I'd say that really well crushed "New OC" taken orally is probably going to give the best effects. To get the best effects, I'd take on a nearly empty or empty stomach, and probably try to boost absorption through changing the environment of the stomach to absorb the drug better. Again, it is my belief that while OC has higher bioavailability through the oral route (compared to nasal), the effects that you get from nasal administration kick in so quickly that to replicate that experience with oral administration, you would have to take a somewhat larger dose to get to the higher max plasma concentrations that are seen with nasal administration. The speed with which the high plasma concentration is reached is another source of pleasure that will feel different in the slower case (oral), regardless if you do the oral dose increase to get similar maximum plasma concentrations. You still will absorb the dose somewhat quickly through the stomach given that your stomach is healthy and not full of food (or anything for that matter), and, if possible, you have increased the environment of your stomach for its ability to absorb the drug readily; White grapefruit and cimetidine are two classic examples of substances altering the absorption of a drug by altering the physical state of the stomach. Fatty meals don't inhibit enzymes like white grapefruit, etc, but they do change the physical environment of the stomach to absorb some drugs (including oxycodone) better. The note I have about this fatty meal tip: eating a fatty meal changes the environment of your stomach in several ways: it alters the pH, etc, on one hand... on the other hand, it takes up space in your stomach. This slows absorption physically by getting in the way of your stomach processing the food/ drug mixture, as makes sense if you think about it. If your stomach has only a very small amount of fatty food and a pill in it, it can absorb that pretty quickly. Not so with the entire fatty meal and pill.
Long post, I know. It was train of thought writing, or whatever the heck you call it. I hope a way to get a snortable or otherwise nasally administrable formula is achieved soon. Until that point, this seems like the best solution, IMO. Other contenders?
