brain damage associated with NMDA antagonists
As far as
I know there's no any proofs NMDA antagonists can lead to brain damage:
"There is thus no published evidence at this time (January 2000) that ketamine can produce toxic cell changes in monkeys. The unpublished monkey data that we know about, that of Frank Sharp, actually shows that there is no damage at doses up to 10mg/kg."
—Karl Jansen, Ketamine: Dreams and Realities (2004)
White therefore concluded that based on some fundamental differences between rat biology and human biology and because there have only been very few studies done on the occurrence of Olney's lesions, no connection can currently be proved or disproved.
— William E. White
Of course not having proofs didn't mean it can't be...
Anyway, I tried combing mxe with 25i-nbome and 2c-e few years ago, both trips were insane. And I did regular doses. For example, I could inject like overal 300 mg of mxe during a day, or I could inject 3 mg of nbome during night (not at once of course; actually that was waste of substance because nbome gives big tolerance right after first trip), or I could eat like 90 mg of 2c-e during 24 hours. But when I did that combo (mxe+2c-e and 25i-nbome+mxe) I took regular doses (~20 mg of 2c-e or even 15 mg because i decided to IMing it and ~50 mg mxe IMing; 1mg of 25i-nbome and the same 50 mg of mxe). At one of those trips I lost myself in my apartment. And when I finally understood where am I, who am I, I went to window and looked outside and then I thought the end of this world is coming -- I literally saw how sky was bent and rolled away like in the
Inception and there were opened blank spaces (
sky is over, right?
) there was cosmos, stars and -- a HUGE black hole (by the way it was sunny morning almost without clouds, probably 10 A.M so I couldn't see stars even if I really really wanted to) which was growing and growing. I even heard and feel some horrible noise like there outside powerful ascending wind which will take all things around and throw to the black hole. All stones, buildings, trees, humans. Everything. I really was frightened with all these feelings and sensory information I received. But I didn't actually panic, maybe even almost calm (this sounds contradictory but I was frightened only at first, then I accepted the fact I and all known world will be destroyed -- it was like when you know something bad will happen and know you can't do absolutely nothing, you just stop thinking about it and let it go no matter how bad it will be) but I still was kept thinking something like: "please, let me go, lesson is learned, please, give me and this world another chance, oh mighty WhatOrWhoeverYouAre". Then suddenly (after 10-30 minutes probably) I stopped see and hear any supernatural things. Seems like that was a peak and it ended.
Never got that high confusing trip not before not later. Maybe once or two but still they were more like 'CEV' (misty and vogue, inside my personality) comparing to above trip if I can describe it like 'OEV' (lucid and clear, outside my personality).
What I wanted to say: theses combos (5-ht psychedelics and at least mxe - or maybe even any dissociative) looks like enhance each other. Because I never was lost at apartment only from 50 mg mxe and never tripped real to such an extent from single dose of 2c-e (or multiplied doses; but I guess if one will take big dose of 2c-e at one time it can give something like I saw and felt).
Now I think it was 2c-e+mxe combo. 25i-Nbome trip was amplified too but if I remeber right there were nothing really extra unusual, so nothing to add.
I was thinking last few days what to order: 2c-e (my favorite #1), 25i-nbome (my favorite #2) or maybe some 4-ho-met or even just silly apbs for upcoming holidays. After I wrote this message I finially inclined to 2c-e
Already have some mxe and now I think I really want to try that combo again %) At least I will know if I remembered right and it was 2c-e combo.