cilosyb
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This should be on a billboard.
The Big & Dandy Methoxetamine Thread - The 3rd Dose
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This should be on a billboard.
amanitadine
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Isn't it? I always thought it was. My doctor seems to think so too but doubt he's read up on it recently. It is related to venlafaxine which definitely is an SNRI and I'm prescribed it as an SNRI for depression. I know it's essentially just a weird ol' drug that's messy as hell whatever it is. SS is listed as a risk of use taken alone or in combination with... fuckloads of things. I've had SS twice now using other (serotonergic) drugs on top of it so whatever it's classified as it doesn't play nice with stims and psyches. Doesn't play nice at all
Yeah tramadol is most certainly an SNRI as well as a serotonin releaser. I dunno if it was the SNRI properties or its action on serotonin but it sure made for a weird long recovery after coming off of it. I know its effects on the MOR weren't responsible, as that was being addressed seperately
Yeah, it is indeed a messy drug...acts as an NMDA antagonist too. I think its "sloppiness" in all the right areas is what makes it such a wonderful antidepressant .Cheers
Do others agree with this like I do? If so, my experiences are much more in line with those of others than I thought. I've previously posted that methoxetamine is shorter in duration for me than is reported on average because, yes, the dissociative effects are pretty much gone at two hours after first alerts (with 50 mg IM or rectal administration at least). I can't fall asleep until the 5 hour point or so, but don't really attribute this to methoxetamine or count it as part of the trip because stimulation is vastly different than the intensely sensational and sometimes visionary experience that precedes it. I'm not sure what it is causing the stimulation (metabolite?) but why should the subjective effects of NMDA antagonism stop if it's really still the same chemical floating between synapses for hours 2.5 to 7 or so?
twelvesevndi
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^^ dunno... potentially a metabolite... potentially acute tolerance to the NMDA agonism mutes that effect while the dopamine reuptake effect continues?
fwiw, i insufflated ~26 mg earlier and spit out the bitter drip. Much more tired than i expected to be at T+4hr... could be tolerance tho?
fwiw, i insufflated ~26 mg earlier and spit out the bitter drip. Much more tired than i expected to be at T+4hr... could be tolerance tho?
I don't know about metabolites but this does resonate with my experience. I thought maybe it had something to do with the reward centres that are being stimulated... one point that I've noticed with tolerance is that different effects become tolerant differently, almost like different brain centres down-regulating at different points in time.... the opioid like effects diminished heavily, the k like dissociation diminished quickly, the trippy closed visuals/open eyed colors etc diminished after that, the only thing that remains with full tolerance is the stimulant effect... the opioid effect hasn't returned yet/probably needs longer abstinence, the dissociative effect returns with higher doses, the trippy visuals return after short abstinence, take a week off and that comes back pretty much like before...
I haven't taken any in 2 weeks, going to abstain for as long as I can... I've been ill lately that's making it easier.
I was thinking that was a possibility. I assume you have such tolerance? I've had three really wild experiences with methoxetamine, all precipitated by a 15 to 20 mg booster to a 40 - 50 mg initial dose around 40 minutes to an hour into the initial dose. That seems to be in the range of a strong dose for people without any tolerance, though. However, I recently tried ketamine doses of 35 mg and 40 mg IM on two different nights and they barely did a thing (far less than they would've done even during my most frequent ketamine dosing periods -- ~500 mg per week during last summer (with my current use of ketamine being maybe once per month). These more recent ketamine tests occurred while using methoxetamine at ~60 mg per day, indicating that the methoxetamine to ketamine developed cross tolerance is, for me, even more intense than ketamine develops to itself, even as the tolerance methoxetamine use develops to itself has remained mild. Weird. It's also worth noting that from the beginning my methoxetamine experiences have followed this short course, even though the start of my methoxetamine use occurred many months after I stopped using ketamine with any frequency (granted ketamine tolerance is said to be of indefinite length).
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socalthizzn
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I agree
^Did you have a pre-existing dissociative tolerance? It'd be nice to hear from some people for whom methoxetamine was their first dissociative or at least that their use of it started after limited prior dissociative experience or frequency of use.
lbeing789: your post recalls an earlier discussion summed up nicely by a post by amanitadine:
lbeing789: your post recalls an earlier discussion summed up nicely by a post by amanitadine:
When I first tried 3-MeO-PCP several BLers were surprised by the profound effect it had on me at a low dose, but I think it is because many of these drugs have a seriously aliner dose-to-response curve, or rather several different curves occurring simultaneously. There is an initial euphoriant/stimulant effect that becomes apparent at a very low dose. I found that 60mg of MXE produced a euphoria comparable to 5mg, but then for the second curve of visual and perceptual distortions a much higher dose is required.
I will agree heartily with your statements about having an alinear curve, and especially in regards to the separate "curve" as to the euphoric effects. I have been experimenting with how low I can take the dose and still register these effects, and given the right environment I can certainly feel 3-5mg, and it is not exactly subtle. I could speculate as to why this but speculation is only so valuable in these kind of situations
twelvesevndi
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I meant acute as in during a given session. idk if that makes sense tho coz redosing works for me.
i have not ever tried ketamine. first tried mxe last monday. have done it about five times now. prefer a 20-30 mg dose.
i have not ever tried ketamine. first tried mxe last monday. have done it about five times now. prefer a 20-30 mg dose.
socalthizzn
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It wasnt my first disassociative but i havnt had any thing like ketamine or nitrous in 4+ years.
Yeah, I ignored the meaning of acute because of that and because other NMDA antagonists last plenty long (DXM for instance -- though I suppose the development of acute tolerance depends on factors that could easily differ between dissociatives).
Thanks, though. Your experiences (and socalthizzen's) are evidence that pre-existing tolerance is not necessarily a factor in this regard, and, coupled with the fact that re-dosing works for you, an indication that the often mentioned duration of 5 - 7 hours does not necessarily include what most consider to be methoxetamine's most defining qualities. That's a definite caveat that should be included in any formal report of its effects. Hell, when considering the advantages methoxetamine would have prior to purchasing I did price per dose evaluations compared to ketamine based on the assumption that the substantial dissociative effects would last at least 3 or 4 hours, concluding that though the price per dose of methoxetamine is higher the effects I'm interested in would last three or four times as long as ketamine. Now that's looking to be false (not that I regret buying it AT ALL, just stating that my assumptions were off).
Lombergerh
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Recently acquired a certain amount of MXE, and would like to know someone tried to mix MXE with anything from a DOx family, will it be a good idea?
50-70mg of MXE + 3-4mg of DOx (DOI or DOB)
50-70mg of MXE + 8-12mg of 2C-P/2C-E
Thanks
50-70mg of MXE + 3-4mg of DOx (DOI or DOB)
50-70mg of MXE + 8-12mg of 2C-P/2C-E
Thanks
knock
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so i've been compiling a little info on this chem & would like to get some reactions from you guys as i have yet to experience this myself
Dosage*
threshold - 5mg
light - 10-20mg
medium - 20-50mg
heavy - +50mg
little physical danger, but risk of being taken to hospital by people unfamiliar with drugs +80mg
*these are all assuming little or no tolerance
Duration
5-7hrs for main effects, slightly longer with heavier doses.
Onset - ~20min-1hr
Peak - 1.5-2.5hrs
Coming down - 2-3hrs
After Effects - roughly a day(?)
The duration items listed are the ones i was most unsure of, and these certainly aren't definitive, just my observations thus far. Do tell if you agree, disagree, would like to add some info.
Hope all's well in NMDA antagonist land :D
I did all this months ago, Mods don't show no respect! And all four of you ignored my PMs, you dicks!
http://www.bluelight.ru/vb/showpost.php?p=9119839&postcount=948
:D
Since you say you base this partially off of F&B's report it's worth noting the following sentence from it regarding duration:
Like me, he seems to consider the definitive effects over when the dissociation subsides, referring to the stimulation as an "afterglow," whereas the insufflated duration quoted above seems to include the duration of the stimulation as well. That, and the fact that the onset for insufflation is so long (much longer than IM or even rectal), probably accounts for much of the dramatic differences in duration between the two ROAs reported above. It may also be relevant that F&B has reported high ketamine tolerance in the past (I'm not aware of his dissociative tolerance at the time of that report), yet just 25 mg of methoxetamine IM was enough for substantial effects.
twelvesevndi
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i insufflated 30 mg mxe, then ate 26 mg 2c-e, in a paper, at T+0:30 and it was amaaaaazing.
26 mg 2c-e for me is probably like 18 mg for most people.
i did another 50 mg mxe at about T+3:00 and it was fun but didn't affect the trip any more substantially, if that makes sense... the trip stayed all plasticy and easy but the mxe started to shine through a bit more.
socalthizzn
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twelvesevndi
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^yes. it went really well. doing the mxe first seemed to eliminate all the 2c-e body negatives. i had also 25 mg diphenhydramine between the two, however.
id say only do one cap of the mxe to start.. 2c-e gives me a weird sedation/spacing-out thing during the come up and this was greatly magnified.... in other news, this was the first time i did not get a headache on the 2c-e comedown! can't say if the redose is necessary for that effect or not, however, or even if it was due to the dph.
hopefully next week i will report back on the effects of a small single pre-2c-e dose and no dph.
%)
id say only do one cap of the mxe to start.. 2c-e gives me a weird sedation/spacing-out thing during the come up and this was greatly magnified.... in other news, this was the first time i did not get a headache on the 2c-e comedown! can't say if the redose is necessary for that effect or not, however, or even if it was due to the dph.
hopefully next week i will report back on the effects of a small single pre-2c-e dose and no dph.
%)
twelvesevndi
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think there are a few good reports of that combo in the current 2c-e B&D thread too
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