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Opioids The Ultimate Opiate Potentiation Thread

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betsym said:
Try DHB, a supplement that increases the absorption of any supplement or drug it is taken with, which is WHY the label says NOT to take it with any prescription medication...It seems to work...
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I would like to hear more about this supplement DHB. I've looked it up and it claims to boost absorption for all supplements and medications. Anyone else tried this? Does it work?
 
Id like to no a bit more about norflex is this prescribed for muscle spasms and RLS?? didnt know it was euphoric or is it only euphoric when combined with an opiate??
 
With Hydro and Oxy, I've found that moderate doses of Tramadol (200-300 mg) transform an otherwise normal opiate high into something more closely resembling the feelings of ecstasy (plus opiates).

I can't take Ultram anymore because I took too much and twice had a seizure. Don't mix ultram with any SSRI-like drugs (in my case it was cyclobenzaprine).

Also, can anyone give a more reasonable answer to the conversion of doses of hydro to OXY. Some say oxy is 1.5 times stronger (7.5 mg hydro= 5 mg oxy) but a pharmacist told me its more like 10 times stronger than hydro. Anybody have a better explanation?
 
Diphenhydramine/Dimenhydrinate sound like two of the best potentiators, from the research I've done.

This is kind of a repost, but I feel it's more apt and will receive more views here - given that the thread I began initially consisted of questions specific to an OTC medication in Canada - however, my questions regarding Diphenhydramine are general in nature.

That said,

""9. Diphenhydramine (Benadryl) -- This antihistamine increases the effects of opiates more or less evenly across the board, and the effect seems to be similar for all natural and semi-synthetic opiates. A normal dose of the opiate can be taken with 25 to 75 mg of diphenhydramine. This mixture should be taken with a bronchodialator/decongestant because diphenhydramine is also a cough suppressant. The green label version of Alka Seltzer cold medicine contains a sufficient dose of decongestant and sodium bicarbonate (which slows metabolism). If the diphenhydramine product contains alcohol, the loading dose of the opiate should be reduced by 30% and the any booster doses should be taken no sooner than an hour afterwards."

Can anyone explain the recommendation of a bronchodilator/decongestant? What would be an example I could throw in the mix (Lorazepam (prescribed), Zoloft, Tylenol 1s (CWE))?
Can't find this "green label Alka-Seltzer" either.

...

What about Gravol (Dimenhydrinate)? [Better/worse than Diphenhydramine? Dosage info? Decongestant a requisite/recommendation as with Diphenhydramine?]"

Apologies if this is an unacceptable repost. The other thread I began can be done away with.
 
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By no means take this as harm reduction advice - it is well known that mixing uppers with downers is particulary dangerous.

For me and my girl, we've found that heroin goes well with a small dose of Ice. I tend to insuffulate 50mg of H, followed 5 minutes later by smoking about 20mg of ice. Really enhances the euphoria somewhat. It produces a really nice buzz without going overboard.
 
I think diazepam helps potentiate oxys.

and I've also heard about grapefruit juice, I've tried it a few times but I think my tolerance is so high I don't really feel it ;\
 
so, i've found out, that grapefruit juice (red, 100% pure) does not potentiate codeine.
jasoncrest said it does (he is smart and a user on bl).
what should i do ?!? :(
 
re: Diphenhydramine necessitating bronchodilator, etc

Regarding the issue of using a bronchodilator with diphenhydramine/dimenhydrinate, or any antihistamine. IMHO, this is just bunk. I think I know the webpage where you read this, or at the least, I have read the same on other web pages, and I don't believe this to be an accurate statement.

Being a cough suppressant has nothing to do with the respiratory drive or with bronchoconstriction/dilation. I think the original author of the statement you refer to got confused regarding cough suppression and respiratory depression. These are two separate and different things.

First, diphenhydramine is not a cough suppressant in the same way as opiates and dextromethorphan (DXM) are. It reduces cough by drying the airways, mostly as a result of the anticholinergic effects of the antihistamines (which are not very receptor selective drugs). DXM and opiates act directly on the cough reflex center to decrease cough.

Even if antihistamines did act on the cough reflex, excessive cough suppression does not equal respiratory depression. This can be seen in the huge, recreational doses of DXM taken by many people. DXM has no opioid activity, and thus does not cause respiratory depression. However, it does act on the cough reflex center and decreases cough. Doses of up to 1000 to 1500mg (30 to 100 times the effective cough control dose) produce no real alterations in respiration.


Respiratory depression can be caused by many things. An opiate overdose can decrease respiratory drive by the effect of opioids acting on opiate receptors within the respiratory control circuitry in the brain. This can be deadly in overdose. Antihistamines can also cause respiratory depression in overdose, but by a distinct pathway than from opioid induced respiratory depression. Antihistamine induced respiratory depression is likely due to a mixture of both antihistamine and anticholinergic effects, is seen only in massive overdose, and a bronchodilator (or opiate antagonist) would do little to counteract this effect.


There is no direct pharmacological link between the supposed cough suppressant effects of antihistamines, the cough suppressant effect of opioids, the respiratory depression caused by opioid overdose, nor the respiratory failure induced by massive antihistamine overdose. There is no good reason to take a bronchodilator with an antihistamine to protect you from respiratory depression when abusing narcotics. If anything, more drugs is just going to result in more side effects and you dying more easily.

As for the amount of alcohol in antihistamine or other medical syrups or elixers, unless you plan on drinking a volume comparable to the amount of vodka you would drink on a bender, you are not going to get any real alcohol effects. The percentage of alcohol in medicines is small (generally), and the volume you consume is small (compared to how much we drink when we are drinking).

Lastly, adding lorazepam will probably potentiate your opiate high, due to the sedative and modest mood elevating effects of lorazepam (similar to a few drinks, but without the ugliness of alcohol). It will also increase the respiratory depressant effects of opioids (i.e. to many Lorries with your Opies = huge oxygen savings







...Before the Wake said of diphenhydramine and opiates... "This mixture should be taken with a bronchodialator/decongestant because diphenhydramine is also a cough suppressant. The green label version of Alka Seltzer cold medicine contains a sufficient dose of decongestant and sodium bicarbonate (which slows metabolism). If the diphenhydramine product contains alcohol, the loading dose of the opiate should be reduced by 30% and the any booster doses should be taken no sooner than an hour afterwards."

Can anyone explain the recommendation of a bronchodilator/decongestant? What would be an example I could throw in the mix (Lorazepam (prescribed), Zoloft, Tylenol 1s (CWE))?
Can't find this "green label Alka-Seltzer" either.

...

What about Gravol (Dimenhydrinate)? [Better/worse than Diphenhydramine? Dosage info? Decongestant a requisite/recommendation as with Diphenhydramine?]"
 
anyone have experience in using flexeril for opiate potination?

what is a good dose?
 
i'd start out with a base dose of 10-20mg and see how you go from that. you're not on any MAOI's or SNRi's? because there have been cases of major contraindication with those types of drugs.

i'm pretty interested in trying out a tri-cyclic for potentiation because my tolerance to doxylamine and promethazine is insanely big at the moment and not worth using half a box of doxy to feel anything nor worth a delirious trip from the prometh.

let us know how it goes.

tyler5 said:
so, i've found out, that grapefruit juice (red, 100% pure) does not potentiate codeine.
jasoncrest said it does (he is smart and a user on bl).
what should i do ?!? :(
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try the white grape fruit juice, it works in my experiences. i wasn't aware that the red does potentiate? if you like the taste of it (i do) then buying the fresh fruit and juicing it is pretty good as well. a bit of sugar added in helps with the taste if it's not your thing.
 
I've experimented with Phenergan and Methadone.

That was fucking insane.

Standing up sideways and drooling over myself.
 
hello in tv land!!
if yall are reading this SWIM just found the most amazing thing to do w/ poppy pods!!
scape or carefully cut away the flakey white lining on the inside of the pod, SWIM says, AND SMOKE IT!!! swim says the high is instantaneous and he got a stiffy from one hit! WOW!!!!!
 
Codeine/DHC and Grapefruit Potentiation; The Definitive Answer!!

Right hear me out, I know you're thinking "not another frickin' grapefruit thread!!" but I am really interested in peoples opinions and experiences with this.

Everybody appears to accept that Grapefruit Juice potentiates opiates, however I have had several experienced opiate users (I'm assuming Codeine and DHC users) tell me that Grapefruit juice doe's NOT potentiate the opiates in question (moreso DHC than codeine).

I can testify that several attempts of potentiating DHC with Grapefruit juice has been unsuccessful (I've not tried it with Codeine yet, don't know whether to bother trying).

So its over to you more experienced users. Doe's grapefruit Juice work to potentiate the afore mentioned opiates (codeine and DHC)?

Yeigh or Neigh? Lets hear yee.......
 
I'd really like to know this as well,as I've heard it inhibits the enzyme needed to convert it to its active metabolites.But I've also heard that by doing this,it forces one of the other enzymes to metabolize more codeine into morphine etc.,to make up for the inhibited one.

I've read all of this here on bl too i beleive
 
I have also read everything on here and other forums and can't seem to get a definitive answer either way.
 
Let me say I felt like it did make a difference. It felt, I would say, longer in duration a little bit. Like, the overall duration was the same, but the peak of the effects was felt longer. The taper off was a faster fall, but I had more good time.

I know its worked with DXM in an interesting fashion also. But I did notice an improvement on my codeine voyage.
 
delsymfan said:
Let me say I felt like it did make a difference. It felt, I would say, longer in duration a little bit. Like, the overall duration was the same, but the peak of the effects was felt longer. The taper off was a faster fall, but I had more good time.

I know its worked with DXM in an interesting fashion also. But I did notice an improvement on my codeine voyage.
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I assume you used it with Codeine then?
 
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