How is telling people to switch strains, instead of raising their dose to combat tolerance, against harm reduction?
Anyways, I see what you are saying, but I'm fairly certain there are some non-opioid sedative alkaloids, as well as non-opioid stimulant alkaloids in red and green/white, respectively.
This is why switching strains *seems* to lower tolerance. Those alkaloids are not dependent on MOR, and thus not subject to opioid tolerance.
Switching strains does not lower tolerance, you are right. But it does bring some enjoyment back to kratom for people. I loved switching 'strains', but the novelty of whatever new alkaloids fades after a day or two.
I usually blend 2 or 3 'strains' these days, so switching doesn't work for me like it used to.
Of course, I'm just speculating. But with me being a connoisseur of sedative drugs, there is definitely something in red 'strains' that is sedating, but not an opioid. It's possibly due to serotonergic effects. It feels like neither opioid or GABA related.