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Not getting high off ketamine

FrankiesCloud

FrankiesCloud

Bluelighter
Joined
Mar 16, 2020
Messages
45
I've been prescribed a specialty ketamine nasal spray that I take everyday supposed to give me a little bit of a sedated effect to help with my pain I take it 6 times a day two sprays each dose I've been on it for about a year now it's worked very well and made me more functioning as well helped tremendously with my depression recently I started not to notice anything when I take my meds I'm thinking it's just a tolerance but I'm on around 200 mg a day do I need just need to go higher on it or take a break
 
You really need to stop using it before your bladder becomes extremely damaged. I can't believe a doctor would prescribe such a high dose of ketamine every day without warning what would happen to your bladder eventually. Your tolerance would be sky high.
 
TripSitterNZ said:
You really need to stop using it before your bladder becomes extremely damaged. I can't believe a doctor would prescribe such a high dose of ketamine every day without warning what would happen to your bladder eventually. Your tolerance would be sky high.
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Wow didn't know that thanks for the info IL remember that I was going to ask up the dosage but now I'll have to think about it also the cost out of pocket payment every gets expensive
 
Don't let @TripSitterNZ scare you, he's been acting silly lately. Still recovering from his latest travels I suppose. You'll feel bladder damage coming when it does.

But that's like 73g in total, over a year? That is indeed quite a lot, and it's surprising tolerance is your only complaint. Or did you do building up to 200mg per day? I guess you did if you suspected tolerance?

So yeah you're expected to experience problems with over a gram a week. As long as you mind and respond to pain signals you should be able to find your own boundaries just fine. It's too bad MXE is gone. It was stronger but only equally as taxing as ketamine, so it reduced its harm, and made it perfectly suitable for cases like yours. MXPr is around, it's expensive but I guess cheaper than clinical ketamine. It's quirky compared to MXE and K, but still close and if it works you'd have an extra safety margin for finding balance.

But just to clear: a tolerance break is never a bad idea either.
 
It's a fact that some people experience severe bladder and kidney issues from ketamine usage... it really is quite surprising that a doctor would prescribe that amount every day for such a long time. If you haven't exprienced issues yet that's a good sign, but there are all sorts of case studies, it's not just ketamine either but any arylcyclohexylamine. To try to pretend it's not a concern would be to brush a lot of peoples' experiences under the rug.

To the OP, eventually you will get a much higher tolerance, which you seem to have done. The only way to get high again is to take a break or increase the dosage.
 
Chris Timothy said:
Don't let @TripSitterNZ scare you, he's been acting silly lately. Still recovering from his latest travels I suppose. You'll feel bladder damage coming when it does.

But that's like 73g in total, over a year? That is indeed quite a lot, and it's surprising tolerance is your only complaint. Or did you do building up to 200mg per day? I guess you did if you suspected tolerance?

So yeah you're expected to experience problems with over a gram a week. As long as you mind and respond to pain signals you should be able to find your own boundaries just fine. It's too bad MXE is gone. It was stronger but only equally as taxing as ketamine, so it reduced its harm, and made it perfectly suitable for cases like yours. MXPr is around, it's expensive but I guess cheaper than clinical ketamine. It's quirky compared to MXE and K, but still close and if it works you'd have an extra safety margin for finding balance.

But just to clear: a tolerance break is never a bad idea either.
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When you say quirky, what exactly do you mean?
 
Chris Timothy said:
Don't let @TripSitterNZ scare you, he's been acting silly lately. Still recovering from his latest travels I suppose. You'll feel bladder damage coming when it does.

But that's like 73g in total, over a year? That is indeed quite a lot, and it's surprising tolerance is your only complaint. Or did you do building up to 200mg per day? I guess you did if you suspected tolerance?

So yeah you're expected to experience problems with over a gram a week. As long as you mind and respond to pain signals you should be able to find your own boundaries just fine. It's too bad MXE is gone. It was stronger but only equally as taxing as ketamine, so it reduced its harm, and made it perfectly suitable for cases like yours. MXPr is around, it's expensive but I guess cheaper than clinical ketamine. It's quirky compared to MXE and K, but still close and if it works you'd have an extra safety margin for finding balance.

But just to clear: a tolerance break is never a bad idea either.
[/ thanks for the response, Dose MXPr work like k or a little different I would giive it a try for the sake of trying it. I also started to cut my daily intake of ketamine and stretch out my dosages to help with my stupid tolerance problem probably will be a while before I notice any effect like I used to
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Xorkoth said:
It's a fact that some people experience severe bladder and kidney issues from ketamine usage... it really is quite surprising that a doctor would prescribe that amount every day for such a long time. If you haven't exprienced issues yet that's a good sign, but there are all sorts of case studies, it's not just ketamine either but any arylcyclohexylamine. To try to pretend it's not a concern would be to brush a lot of peoples' experiences under the rug.

To the OP, eventually you will get a much higher tolerance, which you seem to have done. The only way to get high again is to take a break or increase the dosage.
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Ture I just ended up spreading out my dosages for a month seemed to help for a little bit I went back to the 4 Hour regimen to see if it helped and it do for a little bit. so the best thing to do is just to spread out my dosages as best I can. Unfortunately I do notice when I don't take it I feel very spaced kind of anxious I have Xanax I take 2 milligrams three times a day but still that only does so much
 
I don't want to directly contradict the opinion of a medical professional online but I would seriously get a second opinion about the medications you are prescribed.

6mg xanax every day is going to massively interfere with any of the beneficial effects of ketamine - research into which, it is worth mentioning, is still very much in it's infancy, and none of which has involved such high doses as you are prescribed.

Benzos will generally blunt the subjective effects of ketamine to a considerable degree. I am very surprised that any doctor would prescribe you ketamine - let alone such a high dose - when you are already on a fairly high dose of xanax.

Are you honestly prescribed both of these medications or are you just saying that?

Either way without a doubt the solution is to take a break. I would be very interested to hear more about the specifics of the pain you say it has been prescribed to treat, if you feel like sharing... it must be a highly unusual circumstance is the only thing I can think. Unfortunately it seems unlikely to be sustainable.

Have you discussed these issues with your doctor?
 
Vastness said:
I don't want to directly contradict the opinion of a medical professional online but I would seriously get a second opinion about the medications you are prescribed.

6mg xanax every day is going to massively interfere with any of the beneficial effects of ketamine - research into which, it is worth mentioning, is still very much in it's infancy, and none of which has involved such high doses as you are prescribed.

Benzos will generally blunt the subjective effects of ketamine to a considerable degree. I am very surprised that any doctor would prescribe you ketamine - let alone such a high dose - when you are already on a fairly high dose of xanax.

Are you honestly prescribed both of these medications or are you just saying that?

Either way without a doubt the solution is to take a break. I would be very interested to hear more about the specifics of the pain you say it has been prescribed to treat, if you feel like sharing... it must be a highly unusual circumstance is the only thing I can think. Unfortunately it seems unlikely to be sustainable.

Have you discussed these issues with your doctor?
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No I'm really prescribed both of these medications and more. I have a lot of problems to say the least I'm unable to lift up my left leg they're just making me comfortable
 
Vastness said:
I don't want to directly contradict the opinion of a medical professional online but I would seriously get a second opinion about the medications you are prescribed.

6mg xanax every day is going to massively interfere with any of the beneficial effects of ketamine - research into which, it is worth mentioning, is still very much in it's infancy, and none of which has involved such high doses as you are prescribed.

Benzos will generally blunt the subjective effects of ketamine to a considerable degree. I am very surprised that any doctor would prescribe you ketamine - let alone such a high dose - when you are already on a fairly high dose of xanax.

Are you honestly prescribed both of these medications or are you just saying that?

Either way without a doubt the solution is to take a break. I would be very interested to hear more about the specifics of the pain you say it has been prescribed to treat, if you feel like sharing... it must be a highly unusual circumstance is the only thing I can think. Unfortunately it seems unlikely to be sustainable.

Have you discussed these issues with your doctor?
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And with the Xanax I do try to space that out as well with all my medications I try to do that with it's as needed so I can go up to 6 mg a day I try to take less than that
 
I see, that's interesting, and thank you for sharing, I'm also sorry to hear of your predicament since presumably it is a fairly serious one.

I just did some googling and I must stand corrected also, it seems ketamine can be prescribed up to a maximum dose of 500mg / day. I confess I was thinking more of the very recent therapeutic usage for psychological ailments where the prescribed dose is much lower. But ketamine of course has a much longer history of use for pain. It's for sure unusual for the MOA to be a nasal spray when used in this indication however, but I guess now that nasal administration is available in an officially sanctioned form there is no reason not to use this method for more traditional pain prescriptions.

It actually also seems to be pretty normal for a benzodiazepine to be prescribed concurrently for "neuropsychiatric side effects" - so I stand doubly corrected - not sure if this is what has happened in your case or if the xanax was prescribed entirely separately but I guess it's not nearly as unlikely a circumstance as I presumed, although it's typically diazepam rather than alprazolam - presumably for the greater ratio of sedative to psychiatric effects with the former.

Nonetheless - your xanax dose does look high to me. Are you certain that it's the ketamine that is becoming less effective rather than the alprazolam? I ask also because xanax is not typically prescribed for pain, so presumably a gradual tapering here would be of less consequence - and additionally the title of your thread is "not getting HIGH off ketamine", which to me suggests a psychiatric focus... in which case your dose and frequency of xanax is a relevant factor for sure.

In any case such high doses of ketamine for pain are still somewhat unusual cases and therefore need to be monitored and adjusted by an expert - who should, presumably, also be monitoring your renal and/or hepatic function for the duration. So your best bet is to discuss your concerns with your doctor, and if you're not already getting your kidney and liver function monitored you could also suggest this while bringing up the dangers that you have been made aware of that long term high dose ketamine administration can have.

Good luck to you in finding some resolution.
 
6mg of xanax a day is not a suitable dose for anyone to be on IMO unless they have some sort of utterly crippling ptsd/ocd/anxiety that makes it impossible for them to leave the house, even then that is a large dose.

I would echo the sentiments of other people in this thread and consider getting the opinion of a different doctor.
 
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You don't know what their health condition is so you really shouldn't say... They've made it clear they have complex health issues already.
 
Vastness said:
I see, that's interesting, and thank you for sharing, I'm also sorry to hear of your predicament since presumably it is a fairly serious one.

I just did some googling and I must stand corrected also, it seems ketamine can be prescribed up to a maximum dose of 500mg / da.
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Firstly, I wonder if the OP is taking esketamine. Only esketamine nasal spray is approved in the US, I expect dosages might be different. Also, check that maximum dose again. I think around 500mg is for IM pre-surgery anesthesia. Now I think nasal spray absorption is around a tenth as effective, but still... Doses for anesthesia are way, way above recreational doses. Ketamine generally isn't used "for pain", although it makes some sense if he's been on opioids long term, for chronic pain. But then why title this thread "not getting high?" It's pretty damn clear this isn't a medical discussion board, but he's asking a bunch of recreational users for medical type advice. That makes no sense!
Medically I've only heard of either the psychiatric depression doses, or really high prep for surgery doses. It could be that OP is just really off the mark on what his doses are. The previous poster mentioned "you don't know what health condition", but his numbers are just off-the-charts. I'm not worried about his bladder health, I'm worried he's trolling. If not, apologies, but then, you're on the wrong forum!! You need to consult people with medical experience of ketamine!!!
 
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Mr.Dopamine said:
Firstly, I wonder if the OP is taking esketamine. Only esketamine nasal spray is approved in the US, I expect dosages might be different. Also, check that maximum dose again. I think around 500mg is for IM pre-surgery anesthesia. Now I think nasal spray absorption is around a tenth as effective, but still... Doses for anesthesia are way, way above recreational doses. Ketamine generally isn't used "for pain", although it makes some sense if he's been on opioids long term, for chronic pain. But then why title this thread "not getting high?" It's pretty damn clear this isn't a medical discussion board, but he's asking a bunch of recreational users for medical type advice. That makes no sense!
Medically I've only heard of either the psychiatric depression doses, or really high prep for surgery doses. It could be that OP is just really off the mark on what his doses are. The previous poster mentioned "you don't know what health condition", but his numbers are just off-the-charts. I'm not worried about his bladder health, I'm worried he's trolling. If not, apologies, but then, you're on the wrong forum!! You need to consult people with medical experience of ketamine!!!
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You can’t be a recreational user and also know pharmacology?
 
200mg/day isn't TERRIBLE, I mean, that's not bad. I know I certainly went past that number in a short period of time casually for recreational use.

It's just a little tolerance.

Do you feel more pain/depression when you quit/take breaks?
 
The esketamine nasal inhaler (Spravato) contains a measly 28 mg of esketamine HCl (two doses of 14mg) at a per unit MSRP of $295 USD. And you're meant to use wo or three inhalers per treatment session, let's say once every two weeks, that's 52-78 devices at a cost of $15,000-23,000 per year. That's absolutely insane. $23,000 of ketamine is Tony Montana amounts of ketamine. You could sedate a small European country for like 3 months with that. Even the worst drug dealers would think twice before trying to charge $300 for a single key bump of ket.

(and people are acting like this is some sort of novel innovation... I guess it's a fun fact that Trump supports people using ketamine. Wonder if he's ever K-holed?)

The sad fact of reality is that intranasal ketamine is just not that terribly effective. It's kind of against typical thinking, but my belief is that in some cases it is less harmful to use ketamine in an IM injection rather than intranasally. Yes, needles are a risk, but ketamine has a very long history of safety when given IM (and is even sold in sterile solution) meaning overall you use much less ketamine (saves you money and reduces the risk of bladder damage - which seems to be related to total dose consumed), the effects are much more profound, and your nasal mucosa don't suffer as much. You may find that you can use as little as 1/5 the dose you were previously taking to get similar effects.

I also have heard of people being prescribed ketamine as its freebase in a multi-component cream meant for topical relief of pain. One recipe was 10% ketamine, 6% gabapentin, 2% baclofen, 2% diclofenac, and 2% lidocaine. I know they are less abusable than ketamine sprays/injections, but I don't know how effective they are, and I think they are a specialty medication you'd need to have compounded. One benefit would be that I am unaware of anyone suffering bladder damage from ketamine used topically (not that it's impossible, it's just very unlikely).
 
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