Nope. I've taken it a handful of times at the range of 8mg - 16mg, and I wouldn't say it ever kicked my ass any of those times. The time I took 16mg I think I would have been better off dosing it at about 12-14mg instead, because I was in a fairly social environment, and it left me a little bit woozy or something for about an hour.
I think it's marvelous stuff, I like it in the 8mg - 12mg range. Very magical, tranquil, friendly, warm. It's a lot like mescaline, I've said this before on the forum, but it strikes me as a "technical mescaline", as in it has a technical nature, where you can still use your mind without being completely lost in the cosmos. It leaves you able to compute in all that psychedelic open-ness.
I can notice threshold effects at 1mg, it's very strong stuff, you have to be careful dosing it and don't compare the dosages to other 2C-x expecting it to be comparable - they are all totally different.
That story about the homeopaths is pretty funny They really should have stuck to their normal homeopathic doses.
well, the fact that you haven't gotten your ass kicked by 2c-e is no surprise if you've only dosed up to 16mg.
I'd honestly suggest trying out the 20-25mg dose range, at least one time. I'm not saying that it will be recreational or anything, but higher end dose 2c-e is a truly and indescribably unique and beautiful experience, the good and the bad together - and I say this as someone who is extremely susceptible to the negative physical side effects of phenethylamine psychedelics, 2c-e being no exception. It's something that I think everyone who partakes regularly in the psychedelic experience should experience once.
To answer OPs question: hell yes, it's kicked my ass. To my recollection I've had a full on ass-beating on it around 10 times or so. And I took away something valuable from each beating.