I've been very interested in whether 1P-LSD is actually different from LSD. I've tried it a few times and it felt very similar but I can't say for sure whether there is a difference based on my experiences. It does seem much more visual to me, but every trip is different.
I decided to do some research on the differences people perceive between LSD and 1P-LSD. I read through various posts on reddit and recorded the differences people reported.
Out of 100 people, 50 of them said 1p-LSD is completely identical in every way and the other half reported various differences they have noticed.
11 said its shorter lasting.
5 said its longer lasting.
4 said its more visual.
1 said its less visual.
3 more said the visuals are "different"
3 reported less headspace/spirituality
2 reported stronger mental effects
7 reported a rougher comeup
4 reported a smoother comeup
1 person said it has a rougher comedown
2 reported a smoother comedown
2 people said it has more body load
3 people said it has less body load
It seems that 1P-LSD is pretty much identical to LSD. The differences people describe are mostly contradictory and can easily be attributed to set and setting and dose. The most common differences reported are the comeup and duration, suggesting that it is absorbed into the body at a different rate than LSD which isn't surprising, although the people who report a difference are still in the minority. I would be very interested to see if people can differentiate between LSD, 1p-LSD and ALD-52 in a blind test.
Some people use 4-aco-dmt being different from 40-ho-dmt as an example of why 1p-LSD and LSD are likely different in effects, but thats not really a valid argument. In theory, the propionyl group should block 1p-LSD from binding to receptors, but theres no reason 4-aco-dmt shouldn't be active on its own.
The scientific report on 1p-LSD keeps getting mentioned, but most people seem to misinterpret it. Some people are saying only 38% of 1p-LSD is metabolized into LSD and the rest is active by itself, others say its active before metabolizing but 38% as potent as LSD. From my understanding, the active dose of LSD is 38% that of 1P-LSD in rats. This likely means that it is inactive but 38% was metabolized into LSD by the rats. The report also mentions that it was shown to metabolize into LSD in human serum, but I can't find information on how quickly it occurred or if all of it was metabolized.
I've never done ALD-52, but i could definately distinguish 1P-LSD from LSD. It's the come-up. Once the effects are there, it's hard to differentiate, but the come-up is definately different. It takes at least twice as long for it to fully work. Once you're in it, it's more or less the same.