Yeah that's probably good advice, though if lope truly has a blocking effect at chronic monster dosages, then a taper would most likely need to be set in place first.
Also, as for the warning, it definately is referring to the small ammounts that can cross over the BBB. I read young children are especially sensitive to the effects of loperamide as they are still developing. I've used loperamide several times at relatively high dosages (48mg, 120mg) and can say for certain that I definately did experience some CNS effects. Definately not full on euphoric bliss, but a noticeable sense of feeling content and calm. I used it in place of my usual dose of methadone (40 mg) which I had not taken in two days and it more than kept me straight. Though the half life is significantly shorter than methadone or buprenorphine, for some reason it seems to hold me for a longer period of time.
What I'm truly interested in is the cause for the blocking effect that I've heard reported by so many who use high dosages of loperamide for maintenance. I wonder if this is caused by a high affinity to opiate receptors like buprenorphine, or whether it has to do with tolerance and saturation of the receptors (like methadone). I've researched the stuff a bit, and keep coming up with different answers regarding loperamides potency, we're it able to completely cross the BBB. Some claim that it's actually a very weak opioid similar to Codiene (something I cannot believe due to my owne experiences with it), while others claim that it is incredibly potent.
On the comment about the Lope only having a 10-12 hour half life... This is what I thought as well (according to all the web sites)... until yesterday (I've been quitting a almost 2 year long 400mg Lope habit a day). I always wondered why Lope would hold me for 24 hours or more if it only has an average of 10hr half life? Anyone else get that? Here's how I KNOW that it has a SIGNIFICANTLY LONGER half life... for me, it was very similar in dosing to my year of Suboxone maintenence.
Anyway, I waited over 72 hours since my last Loperamide dose and figured I was 100% in the clear of precip. Well I was wrong and for the first time in all 5 of my opiate using years, I TRUELY precitipated withdrawal like nothing I've ever felt before. Now, back in the day, I had "very mild" precipitation when crossing over from heroin to bupe... BUT NOTHING LIKE THIS. I've never seen that much sweat come out of my body so fast. It only lasted horribly for about 30 min then slowly dissapated. I took 4MG of Xanax and went crazy. My wife said I was hallucenating and she video taped me on her phone for about 10 minutes of it. I hallucenated for 4 hours she said. I remember NONE of it. I watched the video and I dont remember ANYTHING. I thought I was sleeping the whole time. WTF happened? Basically I was in Lope WD, took 4mg of Suboxone then started to Precipitate about 15 min after. Sat there wishing I was dead for 20 min... finally took the 4mg xanax, then I just went crazy. I was talking to objects and I thought they were people. I would carry on weird convos with them that didn't really make sense. I should post the video... I'm still in disbelief.