LSD and 25i-nbome are nothing alike imho, and it does have alot to do with what receptors they hit, i've spent months studying ki values of pages of psychedelics. Psychedelics like psilocin and mescaline and LSD are very special precise molecular keys, which just so happen to hit a very wide range of receptors in the brain. 5-HT1 receptors make up 80% of the brains 5-HT receptors, all 4 sub-families of 5-HT1 are hit by lsd, mescaline, and psilocin...but 25i-nbome does not hit any of them, therefore 80% of the brains receptors are left hanging...I can feel that 25i-nbome is not totally mind-manifesting, but LSD certainly is, as is mescaline and psilocin.
25i-NBOMe is extremely mind-manifesting for me, while LSD is not. No doubt receptor ki values have something to do with it, but you're trying to (futilely and needlessly) quantify a highly idiosyncratic experience. People react differently to different psychedelics due to quite a plethora of factors, including set, setting, metabolic processes in the body and quite a lot of other shit. If you want to be a slave to some numbers that, I repeat, I highly doubt you fully understand (even if you have read "pages" of ki values), go ahead, but I think it's silly.