I've always mused about near methylphenidates that were also near fentanyls.The 4-amino version of methylphenidate is significantly more potent than MPH itself, but can't know if it has aniline-like toxicity...
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The SwissTargetPrediction also gives it a slim chance of binding to mu receptor.
If someone were to make a non-amine MPH with the piperidine nitrogen removed or replaced with oxygen, it would be easier to purify if it had an amino group on the benzene ring.
Edit1: Also, making it a 4-aminoethylphenidate gives it a little bit more likelihood of binding to mu receptor, similar to meperidine SAR.
Edit2: And, by reducing the shit out of antibiotic chloramphenicol, you could obtain an equivalent 4-amino version of amphetamine.
I drew some amine compounds like this in another thread:I've always mused about near methylphenidates that were also near fentanyls.
Reminds me of Org 6582: