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polymath

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^ Quite unusual that this only has the N atom corresponding to the indole nitrogen... I tried to think of an ibogaine/harmala kind of derivative but you obviously can't build that from this compound.
 

polymath

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Pawhuskin A is a cool compound, non-nitrogenous kappa receptor (mainly) blocker.

1574091111428.png

You could probably use that as an addition to a non-selective opioid agonist like the akuamma alkaloids, which bind more to kappa than mu receptors and therefore aren't very euphoric by themselves. Much like the "blue velvet" mixture of pentazocine and an antihistamine (I guess that mixture works because the sedative antihistamine potentiates only the mu agonist effect and not the kappa).

Edit: someone with any level of actual physical dependence to opioids probably shouldn't try balancing like that, tho...
 
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polymath

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The 4-amino version of methylphenidate is significantly more potent than MPH itself, but can't know if it has aniline-like toxicity...

17784

The SwissTargetPrediction also gives it a slim chance of binding to mu receptor.

If someone were to make a non-amine MPH with the piperidine nitrogen removed or replaced with oxygen, it would be easier to purify if it had an amino group on the benzene ring.

Edit1: Also, making it a 4-aminoethylphenidate gives it a little bit more likelihood of binding to mu receptor, similar to meperidine SAR.

Edit2: And, by reducing the shit out of antibiotic chloramphenicol, you could obtain an equivalent 4-amino version of amphetamine.
 
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polymath

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The essential oil of aniba canelilla tree is unusual in containing a nitro compound, 1-nitro-2-phenylethane... That could be used in producing alpha-benzylphenethylamine, but unfortunately that compound doesn't seem to be an amphetamine-like stimulant.


18404
 

polymath

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A really dangerous idea:

make a quaternary ammonium compound from the antiglucocorticoid mifepristone, and take it as a peripheral glucocorticoid blocker with a huge dose of dexamethasone to get only the CNS effects of the latter.

20344

 

Nagelfar

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The 4-amino version of methylphenidate is significantly more potent than MPH itself, but can't know if it has aniline-like toxicity...

View attachment 17784

The SwissTargetPrediction also gives it a slim chance of binding to mu receptor.

If someone were to make a non-amine MPH with the piperidine nitrogen removed or replaced with oxygen, it would be easier to purify if it had an amino group on the benzene ring.

Edit1: Also, making it a 4-aminoethylphenidate gives it a little bit more likelihood of binding to mu receptor, similar to meperidine SAR.

Edit2: And, by reducing the shit out of antibiotic chloramphenicol, you could obtain an equivalent 4-amino version of amphetamine.
I've always mused about near methylphenidates that were also near fentanyls.

...

Wishing I had the specs to this one below, tried against the phenyltropanes.

Note the C1 position substitution, not a mistake, though maybe add a C2 position carbmethoxy
 

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Nagelfar

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