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Lysergamides The Small & Handy 1V-LSD thread

Nervewing

Nervewing

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Jan 5, 2016
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New on the market, being released just as the German NPS ban goes into place. The ban stipulates that at the N1 position, a carbonyl group can be no longer than 4 carbons. The obvious step is just to make one with 5 carbons!
This gives us 1V-LSD, the V for Valeroyl, an alternate name for a pentanoyl group (I guess 1Pe-LSD would be more confusing and sound less flashy). No reports of consumption yet but speculations and eventual bioassays can go into this thread! I speculate it will be a similar prodrug to LSD like all of the other N1 substituted lysergamides, though this still remains to be seen (I am also an adherent to the hypothesis that LSD prodrugs aren't fully metabolized and some of the original material crosses the BBB, yielding a unique experience). What this one is like however, remains to be seen! Potentially a very exciting develpoment
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The RC manufacturers do really need to step up their game. What's next? 1-Hexadecionyl-LSD?
There are many more interesting substutions (PRO-LAD, ETH-LAD, etc) that could be further explored, instead of another weak LSD-prodrug, the amide chain will be almost the size of the entire LSD molecule soon
 
C8-diethylamide and N6-methyl are generally accepted as the best substitutions. Hofmann made a miracle. ETH-LAD was done, was not well accepted. AL-LAD was good but weak and short lasting. All the other C8-amides are sub-optimal. Further functionalisation generally leads to inactivity.

LSD (or its prodrugs) are the vehicle in which we relive our past, present and future.
 
@Gandalf- idk ethlad was well received in these circles. Im
Not sure that designing drugs specifically to evade drug laws is THE way forward ... but perhaps it might make them realize the ridiculousness of it all.

@Nervewing do you mean no shorter than 4 (if 1V is 5 Cs)? ...
 
HOOH said:
The RC manufacturers do really need to step up their game. What's next? 1-Hexadecionyl-LSD?
There are many more interesting substutions (PRO-LAD, ETH-LAD, etc) that could be further explored, instead of another weak LSD-prodrug, the amide chain will be almost the size of the entire LSD molecule soon
Click to expand...

Agreed, however, the 6-subs are much lower in yield and more difficult to synth than the 1-subs.

Ismene2 said:
Never thought much of al-lad seemed to just make shit wavy.
Click to expand...

You haven't taken enough then. I found that more is needed than LSD but at the right dose it is absolutely lovely, quite unique and strong.
 
IIRC this one was in the pictures that *someone* shared with us that had like half dozen different ones for the test group

edit: not so sure of the nickname anymore
 
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HOOH said:
The RC manufacturers do really need to step up their game. What's next? 1-Hexadecionyl-LSD?
There are many more interesting substutions (PRO-LAD, ETH-LAD, etc) that could be further explored, instead of another weak LSD-prodrug, the amide chain will be almost the size of the entire LSD molecule soon
Click to expand...
The sole purpose of this drug is for the people in Germany that want to experience LSD since LSD-25 is a pain in the ass because the dosages are way off. ETH-LAD and PRO-LAD are completely different.


Gandalf- said:
C8-diethylamide and N6-methyl are generally accepted as the best substitutions. Hofmann made a miracle. ETH-LAD was done, was not well accepted. AL-LAD was good but weak and short lasting. All the other C8-amides are sub-optimal. Further functionalisation generally leads to inactivity.

LSD (or its prodrugs) are the vehicle in which we relive our past, present and future.
Click to expand...
Short acting? I've never done AL-LAD but IIRC it has a 8h+ duration.
 
hoxyz said:
ETH-LAD and PRO-LAD are completely different.
Click to expand...
No they aren't.

They're somewhat maybe possibly perhaps different, but definitely not "completely different". And they're definitely substitutes for each other.
 
HOOH said:
No they aren't.

They're somewhat maybe possibly perhaps different, but definitely not "completely different". And they're definitely substitutes for each other.
Click to expand...
I dunno I'd say the whole fractal images forming greater images rather than fractal geometric patterning does kind of set it completely apart from other lysgeramides. There is little I found about it to have in common with LSD bar the general feel I find lysgeramides to hold.
 
I'd rather have pro lad or pargy lad or ip-lad or anything that isn't just another pro drug for lsd. I can't really tell 1p from 1cp both of which i have lots of, and ALD-52 too. Unless this is better for some reason I'm probably not going to bother, I never tried 1B-LSD either. I'm somewhat surprised German market is big enough to invent whole new lysergamides for.
 
psynce of sound said:
I dunno I'd say the whole fractal images forming greater images rather than fractal geometric patterning does kind of set it completely apart from other lysgeramides. There is little I found about it to have in common with LSD bar the general feel I find lysgeramides to hold.
Click to expand...
Which drug you're talking about?
 
Of all the ones I’ve tried OTHER than lsd-25, ETH-LAD is my fav.
Visuals are nuts and if the body load is under control, it’s a great ride.

1V is now just another to try, cross it off the list!

It’d be cool if they could tinker with duration; to come up with a 4-6 hour version of a lysergamide.
 
psynce of sound said:
Eth-lad, my apologies I should of been specific when i first commented. My bad

Yeah though I really don't see much about eth-lad that is similar to lsd.
Click to expand...
Generally speaking going from a methyl to an ethyl won't make any real difference in a drug (inb4 methanol-ethanol comparisons), especially in a molecule as large as LSD. They are for all intents and purposes the same, and all "differences" should be attributed to placebo or just the standard case of trips being different each time.

I think a lot of this just comes down to people wanting there to be more psychedelics, so they attribute minor molecular differences to experiential changes.
 
HOOH said:
Generally speaking going from a methyl to an ethyl won't make any real difference in a drug (inb4 methanol-ethanol comparisons), especially in a molecule as large as LSD. They are for all intents and purposes the same, and all "differences" should be attributed to placebo or just the standard case of trips being different each time.

I think a lot of this just comes down to people wanting there to be more psychedelics, so they attribute minor molecular differences to experiential changes.
Click to expand...
Have you actually tried eth-lad or are you speaking purely from a theory pov?

I'm telling you as a person who has tried a lot of both lsd and eth-lad the two are distinctly different with only the general feel of a lysgeramide. Much like how all tryptamines and phenethylamines have a distinct character that all share in the class.

Beyond that the similarities end. One (lsd) produces vivid colours and geometric patterning, the other (eth-lad) produces images from your subconscious in fractal form which ultimately lead to bigger images made from a the little ones. Some minor colour changes but nothing like LSD.
I'd also say eth-lad's intense ability to cause strong nasuea at doses above 150mics every single time without fail also makes for incredibly distinct Pharmacology that departs from that of LSD.

As I've said having consumed both I find there to be little in common at all. Certainly not enough to say the two are basically the same, they really arent.
 
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