I know zyprexa is supposed to affect your roll, i'm rolling for the first time in 2 years this sunday, and i wanted to know a couple of things. How much will a low dose of zyprexa(5-7.5 mg daily at night) affect my roll? I'm also taking piracetam(started last week), will this negate or counter some of the diminishing effects of zyprexa?
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zyprexa and piracetam and mdma
- Thread starter jazir5
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since zyprexa is an antagonist at both serotonin and dopamine receptors, you will most likely not roll or have severely diminished effects, and i doubt the piracetam will save it. furthermore, since zyprexa is metabolized by cytochrome P450, there can be serious interactions with the metabolism of both the zyprexa and the mdma. in the interest of harm reduction, i strongly suggest you do not take any mdma until you are off the meds.
Folley
Bluelighter
A whole lot.. You're likely to feel nothing, while putting yourself at high risk of seizures and Serotonin Syndrome.
No, taking more drugs isn't going to change the down-regulation that is keeping you from rolling.
I'm on zyprexa for schizoaffective disorder. I am also on lamictal. How long would it take for a reduced dose to matter/take effect? Would i be able to ween myself off of zyprexa and remain solely on lamictal and have no symptoms?
Also i'm not particularly worried about a relapse or episode, i smoke a ton of weed everyday with no side effects, i'm just wondering if lamictal alone can manage my symptoms
For some background i took 4 pills my first time(incredibly retarded) two of which i later found out were laced with meth. i went into a psychotic episode for 2 weeks, and was placed on antipsychotics and celexa.
I have had no psychotic symptoms in over a year a half, just mood problems likely due to the celexa. Being on lamictal has completely evened me out, and i'm now off the celexa.
please mention all medications you are taking when asking about potential interactions. while some may be safe(ish), others can be lethal combined with mdma. furthermore, weed and mdma have completely different mechanisms of action. weed is a relatively harmless drug and its hard to find anything dangerous to mix it with. mdma on the other hand is a serious drug that floods your brain with neurotransmitters, and if a medication interferes with your brains natural ability to deal with this release you could end up dead very quickly.
the lamictal will definitely effect the roll. i see some interactions between lamictal and antidepressants due to the serotonin release causing respiratory depression, and mdma is a very powerful serotonin releaser. i also saw no dangerous interactions between amphetamine and lamictal, likely due to the fact they should cancel each other out. also, both meds you mentioned and mdma are metabolized by the cytochrome enzyme, which will affect the half-lives of these drugs.
by taking mdma with your medications you are playing russian roulette. neither of these medications should be stopped cold turkey, both need to be tapered to avoid things like seizures and suicidal thoughts. its not a clear-cut "you will die/you will be fine" but is it really worth risking your life? the other outcome i see is that you waste mdma due to the effects being blocked/severly diminished, possibly with a terrible comedown due to the change in the rate of mdma metabolism (all 3 drugs would be fighting for the same enzyme active site)
tl;dr - i would suggest not rolling
the lamictal will definitely effect the roll. i see some interactions between lamictal and antidepressants due to the serotonin release causing respiratory depression, and mdma is a very powerful serotonin releaser. i also saw no dangerous interactions between amphetamine and lamictal, likely due to the fact they should cancel each other out. also, both meds you mentioned and mdma are metabolized by the cytochrome enzyme, which will affect the half-lives of these drugs.
by taking mdma with your medications you are playing russian roulette. neither of these medications should be stopped cold turkey, both need to be tapered to avoid things like seizures and suicidal thoughts. its not a clear-cut "you will die/you will be fine" but is it really worth risking your life? the other outcome i see is that you waste mdma due to the effects being blocked/severly diminished, possibly with a terrible comedown due to the change in the rate of mdma metabolism (all 3 drugs would be fighting for the same enzyme active site)
tl;dr - i would suggest not rolling
First person to say lamictal would interact. I've even seen numerous reports on this site that they have no interactions. As far as i've read multiple people have said it won't affect the roll. And OF COURSE i would taper, as i know how dangerous it is to just play with medications that you may or may not depend on for you're sanity.
I really want to know if lamictal can be used alone without an anti-psychotic to manage my symptoms of schizoaffective. I haven't had psychotic symptoms in over a year, just mood problems. My doctor thinks i lean more toward the bipolar side of the spectrum than schizophrenic. Would lamictal be able to manage all/most of the symptoms of the disorder alone? What would be your recommended taper speed from zyprexa?
if you want to taper from zyprexa as fast as possible with the fewest negatives, i would suggest cutting your dose by 25% of the maximum every week. its hard to get good numbers from 5mg, so lets use 10mg for example. first week, take 7.5mg, second week take 5mg, third week take 2.5mg, 4th week you should be off, dont roll till 5th week. with 5mg, it may be better to cut your dose by 1mg every 5-6 days.
im not really qualified to tell you what medications you should take, you need to talk to your doctor/psychiatrist about that.
even if the lamictal does not noticeably alter the subjective effects of mdma, it will interact with your liver enzymes. also, it is a sodium-ion channel blocker. sodium receptors are used to convey instructions for nerve cells to fire, by blocking this it can prevent seizures. high levels of serotonin (like dangerously high) can cause seizures.
at the end of the day, its your life to do what you want with. here at BL we can only suggest what not to do. please be careful.
heres one report from erowid about mdma and lamictal:
http://www.erowid.org/experiences/exp.php?ID=91904
edit: spelling mistakes lol
im not really qualified to tell you what medications you should take, you need to talk to your doctor/psychiatrist about that.
even if the lamictal does not noticeably alter the subjective effects of mdma, it will interact with your liver enzymes. also, it is a sodium-ion channel blocker. sodium receptors are used to convey instructions for nerve cells to fire, by blocking this it can prevent seizures. high levels of serotonin (like dangerously high) can cause seizures.
at the end of the day, its your life to do what you want with. here at BL we can only suggest what not to do. please be careful.
heres one report from erowid about mdma and lamictal:
http://www.erowid.org/experiences/exp.php?ID=91904
edit: spelling mistakes lol
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I'm hesitant to believe that story as he said he let his friend get the pills, and did not perform any sort of test kit on it. Also he mention he took 2.5 pills, which could have contained a massive amount of mdma and/or any sort of harmful chemicals.
I know you're not qualified, and obviously i won't base my decision on one person on bluelights perspective alone, however you seem pretty educated, and i would really, REALLY like your opinion on the issue. It was a long journey to recovery from that incident, and now that i am better, i obviously want to be on as few heavy duty psychotropic medications as possible. Being on one med for the first time in 2 years would be a dream, so any information that could help facilitate that would be greatly appreciated
if youre still determined to do it, make sure you dont stop taking your lamictal unless you taper off, and wait until youre off the zyprexa at least one week. there seems to be some side effects with lamictal that causes skin rashes and/or necrosis when the dose is changed too suddenly.
also, this goes without saying, but make sure you test your mdma, and keep the dose reasonable (100mg-150mg). if you dont feel it, then dont take more, just accept that you cant roll on these meds. and if you take the lamictal for mood stabilization instead of as an anti-epileptic, you may want to treat mdma as a psychedelic (set and setting) to reduce the risks of a psychotic episode.
you said that your first roll resulted in a psychotic episode for 2 weeks. you may feel better now, and it may not happen again with pure stuff at a reasonable dose, but it also may cause your lamictal to stop working properly during the recovery period when you have no serotonin left. also, avoid 5-htp due to possible respiratory depression (like ssris and lamictal), stick to high tryptophan foods instead.
but really, maybe mdma is not the drug for you
one more thing: an anecdotal report from someone mixing lamictal and mdma
http://wiki.answers.com/Q/Can_you_take_lamictal_and_ecstasy_together
also, this goes without saying, but make sure you test your mdma, and keep the dose reasonable (100mg-150mg). if you dont feel it, then dont take more, just accept that you cant roll on these meds. and if you take the lamictal for mood stabilization instead of as an anti-epileptic, you may want to treat mdma as a psychedelic (set and setting) to reduce the risks of a psychotic episode.
you said that your first roll resulted in a psychotic episode for 2 weeks. you may feel better now, and it may not happen again with pure stuff at a reasonable dose, but it also may cause your lamictal to stop working properly during the recovery period when you have no serotonin left. also, avoid 5-htp due to possible respiratory depression (like ssris and lamictal), stick to high tryptophan foods instead.
but really, maybe mdma is not the drug for you
one more thing: an anecdotal report from someone mixing lamictal and mdma
http://wiki.answers.com/Q/Can_you_take_lamictal_and_ecstasy_together
I wasn't planning on stopping the lamictal at all. I like that medication, and it has seriously improved my mood, with absolutely no noticeable side effects(except reduced hunger which is a positive). However, like i said, zyprexa has all these nasty side effects on me such as: weight gain(20 pounds), raised cholesterol, raised triglycerides, increased blood pressure. It also has a high risk for diabetes.
I'd still like a more fleshed out answer on whether lamictal could manage possible psychotic/manic symptoms alone at least minor ones.
from wiki:
also, just realized that lamictal isnt primarily metabolized by CYP450, its renal elimination, so there should be less interactions with the actual metabolisms of mdma and lamictal.
either way, if you want to roll, you need to get off the zyprexa and let your mood stabilize for a little bit first
also, just realized that lamictal isnt primarily metabolized by CYP450, its renal elimination, so there should be less interactions with the actual metabolisms of mdma and lamictal.
either way, if you want to roll, you need to get off the zyprexa and let your mood stabilize for a little bit first
Right. Makes sense. I plan on going from 5 to 2.5, holding there for about a week and a half, 2 weeks. then 1.25, then 0. I imagine the transition between 2.5 and 0 is gonna be the hardest part, so i will probably take that as slow as possible
Also it would be great if someone could start a end-all questions of zyprexa with mdma thread. There's one for seroquel. Perhaps one for just anti-psychotics in general, including pharmacology
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Meth caused me significant problems, and i took 4 pills at my first time, 2 of which i bought from some random dude at a rave, so i have no idea what those contained. i didn't preload or postload, and i had already untreated psychotic symptoms. My situation is completely different now, and i have had things under control long enough that i feel comfortable experimenting again.
Um, yeah not when you have schizophrenic or psychotic tenancies. THC can be a huge trigger in psychotic episodes. I dated someone for over two years with severe Paranoid Schizophrenia (complete with catatonic episodes) and smoking weed is one of the worst things you can do.
in this context i was referring to physical problems and drug interactions. obviously any psychoactive substances should be avoided with a current or underlying psychological disorder as this can be a trigger
I smoke an 1/8th a day sometimes. I have been smoking pretty much since i got out of the hospital, and it actually helped me put myself back together. While thc can be a psychotic trigger, cbd the other major chemical in marijuana has anti-psychotic properties. I only smoked indica the last year and a half, which is high in cbd. I have a very very mild case of schizophrenia/schizoaffective, I'm pretty high functioning and i have only had 1 psychotic episode. Please don't worry about me, i'm pretty experienced with my own mental health.
tl;dr everyone's body is different, everyone reacts to the same substances in different ways
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