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Zoloft and MDMA

SSRIs
Mechanism of Action
SSRIs (Selective Serotonin Reuptake Inhibitors) work by selectively inhibiting the reuptake of serotonin. Thus, more serotonin remains for a longer period of time in the synapses. Although the different SSRIs vary in how effective they are at inhibiting 5-HT reuptake, they all do so selectively, and thus they do NOT have a direct (significant) effect on other NTs.

Common Side Effects
Insomnia, sedation (thought not nearly as severe as with the TCAs), tremor, gastronintestinal problems, rashes, sexual dysfunction (decreased libido and difficulty orgasming), acute anxiety.

Metabolism
SSRIs inhibit, to varying degrees, the enzymes CYP1A2, CYP2C19, CYP3A4 and CYP2D6. SSRIs and their metabolites can take a long time to completely leave the body. The issue with SSRIs is that in addition to the immediate effect they have on the brain, they also alter the brain in such a way that it takes some time after going off the SSRI for the brain to return to its normal configuration. How much a person's brain has been altered (and thus how long it will take for their brain to become normal again, and thus able to feel the full effects of MDMA), depends on the dose of the SSRI the person was taking, as well as the length of time the person was taking it for. So you can see, the time the person needs to be off an SSRI in order to, say, roll effectively will vary greatly from person to person. And that's not even taking into account a person's unique brain chemistry and metabolism.
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MDMA/Ecstasy (includes MDA, MDEA etc) and SSRIs: It is NOT POSSIBLE TO ROLL while taking an SSRI! It is a COMPLETE and UTTER WASTE OF YOUR MONEY! Basically, SSRIs 'block' the part of your brain where the MDMA needs to go in order to get you high; and since MDMA can't get in there, you won't be able to get high. You might experience some weak 'speedy' effects from high doses of MDMA, but you will not be able to truly 'roll'.

Do NOT stop taking your SSRI so that you can roll. First of all, even if you stop taking it for a few days, it is unlikely that you will fully be able to roll. It takes much longer than a few days for all the SSRI (and its metabolites and effects) to leave your body (read above under 'metabolism'). Second, you can get VERY SICK (withdrawal symptoms, depression, etc) if you stop taking your medicine. I strongly suggest that you give up rolling while you are taking an SSRI.
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Link

FM
 
Excellent information from FlowMotion. I just want to second the warning against stopping your zoloft. I've tried this before, and even after months off zoloft my roll was significantly weakened. And even if you do want to stop taking it for more legitimate reasons, don't do it overnight, you'll risk some very nasty side effects if you don't taper slowly (best to talk to your Dr. about it).
 
A side note relating to the topic, I have consumed MDMA(tested) I had a mild roll, with no comedown. I'm curious as too how I'm able to roll (even mildly) while on SSRI's and will Xanax be an issue with future roll's.
 
There are reports that for some people a SNRI or SSRI will allow a dulled roll, but a roll non the less

Xanax will also dull a roll and sedate you, dont take it at the same time as your roll
 
Rolling on SSRIS is just not good in general. I have before and felt some nasty side effects. As for the withdrawal off them. Its very tough. Takes about 2-3 weeks. depending on your dosage. I do take a xanax at the end of my roll to make me sleepy. Benzos work a bit different than SSRIs. But your body can be really depending of benzos if you abuse them and thats really no good. be safe
 
I am not positive but I have heard that you take Valium/diazepam (Benzos) to pull yourself out of a roll.

I dont know who would ever want to do that, but maybe if you were having a "bad roll" (if those even exist) or maybe like pinkstarz said, if you want to go to bed.

Personally i just smoke some green before bed. It takes away any residual "speedy" feeling and leaves you with a nice glow so the sheets and what not still feel beautiful, but you can still sleep.
 
It should actually stop you from getting the full effects. Strangely though I know someone who uses E and has been taking Zoloft daily for years, when they started taking pills they would take like 1/4 to 1/3 of a pill to get high. They used to mostly snort them so they would buy a pill and crush it and get 3-5 lines where they would do a line every 1-2 hours and go all night off one pill.
 
Zzyzx said:
There are reports that for some people a SNRI or SSRI will allow a dulled roll, but a roll non the less
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You would presumably get the dopamine and noradrenaline effects, so it would still be some sort of a high. And if you're in a good environment, like a rave or club that you enjoy, then that would make you happy/euphoric. So it could be close to the desired effects.
 
Infinite Jest said:
You would presumably get the dopamine and noradrenaline effects, so it would still be some sort of a high. And if you're in a good environment, like a rave or club that you enjoy, then that would make you happy/euphoric. So it could be close to the desired effects.
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I suppose that must be it then! Well regardless I have a good time, while I roll! :)
 
zoloft and MDMA

Ok, i have spent hours researching this issue in order to optimize timing for an upcoming roll for a friend. I do know that zoloft as an SSRI blocks MDMA from accessing the neurotransmitter and dumping stored serotonin but possibly not completely. I did actually find a research study that measures the effects in 6 or 7 different areas of MDMA, a placebo and MDMA with an SSRI and it showed that the effect with an SSRI was 2.5 times less approximately across the board on all measured areas. If I find the report again I will provide the link.

My question is with a dose of zoloft of 50mg for 3 weeks and then a 2 week period without any dosage, is that enough time to experience the effects of the MDMA from serotonin and not just dopamine and noradrenaline? I understand that the half life of zoloft is 26 to 36 hours but is dependent on the dose and term of application. I believe from everything that i have read that I will have a worst case good time from the dopamine and noradrenaline and possible best case full effect from the serotonin as well. I am thinking about doubling the MDMA dosage after an initial single dose to make sure but if anyone has any advice or insight, please share?!!
 
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