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yohimbine and lsa

Lopez

Lopez

Bluelighter
Joined
Oct 21, 2010
Messages
416
so i've been taking yohimbine (and androstanediol) 3x daily in the supplement methyl-masterdrol v3. it's worked for me (turned a lot of fat into muscle) but lately my OCD has been ruining my motivation and drive for lifting (repressing the passion and drive if you will) and i feel i think i need some time to myself to "reflect". anyway i was reading up on yohimbine interactions with lsa (hbwr) and i've heard that it's actually a very good potentiator of psychedelics. a bell went of in my head...

how does yohimbine *potentiate* a psychedelic if it's a 5-ht and d2 receptor antagonist? also, what gives it it's mildly "psychedelic" effects?

will it actually potentiate a dose of lsa? or will it quell the effects? :\
 
It won't potentiate psychs, it will (in theory) block the effects because LSD and other psychedelics are 5-ht receptor agonists.

Plus LSD and whatnot are already stimulatory/vasoconstricting enough without needing an adrenergic stimulant like yohimbine involved. Even if they did still work it would be a very unpleasantly stimulating experience.
 
yeah, yet somehow i keep coming across these posts: http://www.bluelight.ru/vb/archive/index.php/t-279818.html

they refer to yohimbe as a weak maoi, yet how does a *weak* maoi such as the yohimban alkaloids potentiate a psychedelic, especially since the majority are said to have 5-ht/d2 antagonist properties? something tells me that the reported mechanism of action of yohimbe is wrong.

that or maybe the trippers in the post got their hands on some powerful acid :|
 
Lopez said:
how does a *weak* maoi such as the yohimban alkaloids potentiate a psychedelic, especially since the majority are said to have 5-ht/d2 antagonist properties? something tells me that the reported mechanism of action of yohimbe is wrong.
Click to expand...

Not sure personally. I would suggest that you post this over at Advanced Drug Discussion. They might be able to help.
 
Yohimbine is primarily an antagonist at adrenergic alpha-2 autoreceptors (say that 5 times fast... i.e. it increases your body's release of norepinephrine/adrenaline) so I could see it 'potentiating' a LSD trip by adding a strong stimulant edge. I think the 5-ht/dopamine activities are secondary.

I also personally believe that yohimbine is not a MAOI at normal dosage levels. It's just a stimulant.
 
yeah, i find this whole interaction quite fascinating though haha. thanks guys :)
 
I believe yohimbe can increase dopamine in your brain by up to 80%....perhaps this has something to do with it. I have used it as a mood stabilizer for said dopamine activity.
 
yohimbine and LSA is a great combo. I've done it before. it completely relieves vasoconstriction, slightly potentiates the LSA(mild maoi), and gives a nice stimulant effect. highly recommended combo
 
Just tried p-boost after reading some reviews about it. Worked good but pretty pricey. The trial was free but you have to pay for the shipping which was quick. Anyone know any coupon codes for p-boost.com?
 
From what my pup's been reading the past few hours, yohimbine is a -weak- MAOI, and even may need to be redosed over a week to reach full MAO inhibition. It is not vasoconstricting, it's actually a wonderfully powerful vasodilator (google it, it's on basically every sight that has any information about yohimbe/yohimbine). Also, the effects are stimulating, as just about everyone knows, which may counteract the sedative effects produced by LSA. My pup may be trying this combo out sometime soon, hopefully he'll have the time to come back and post a report. Further analysis of yohimbine and its MAOI properties would be appreciated :D
 
Oh! Side not: it "has high affinity for the α2-adrenergic receptor, moderate affinity for the α1-adrenergic, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors. It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A. Its intrinsic activities at the other sites listed are unclear/unknown, but it is probably mostly antagonistic at them." That being said, it may potentiate because it affects 5-HT1a, however, if my memory serves me correctly, 5-HT2a is the receptor through which psychs work their magic. From Wikipedia^^
 
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It is a 5ht2a antagonist while psychedelics are 5ht2a agonists, this means it's likely to reduce the effects of the experience rather than potentiate them ;)
 
Pharmacology aside, I found it did indeed alter mornig glory seeds, but did not make them stronger. It is interesting that it is a serotonin antagonist because it DEFINITELY did not weaken the effects. I also took Yohimbine (herb, not the isolated alkaloid) with LSD and found the same 'altered dimension.'
 
I had taken about 600 seeds, did a CWE, took about a dropper's full of yohimbe and then drank my solution. No vasoconstriction whatsoever (and I get HORRIBLE vasoconstriction every time), and I had a much more trippy and pronounced headspace. However, not many visuals were attained, possibly from antagonistic interactions, or the fact that my seeds were about 13 months old... 8) I'd also like to note that I've tried MGs through CWE about 6 times, and straight up eating them about 3. Anyone else have any reports to confirm/dismiss my experiences? I know of one report where someone else did the exact same thing (with fresher seeds, mind you) and had a pleasanter experience than his other MG endeavours. Don't know if this is conformation or placebo. Thanks for the replies, guys!

P.S. I use a liquid extract of yohimbine if that helps.
 
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