YK-11 and MK-677

Fractality

Fractality

Bluelighter
Joined
Apr 12, 2014
Messages
91
YK-11:

Novel steroidal selective androgen receptor modulator (SARM). Partial agonist of the androgen receptor. Significantly upregulates expression of follistatin (Fst), a myostatin antagonist.

MK-677:

Synthetic growth hormone secretagogue. Increases serum insulin-like growth factor-1 (IGF-1).


Does anyone have experience with either one of these?

I'm most intrigued by the YK-11. I can't find any info about its recommended dosage/protocol.
 
nolys said:
That yk-11 sounds very interesting though never heard of it.
Has this just recently been synthesised?
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Indeed it is very interesting. It's pretty recent, yes. There are only two studies published on it out there. No human studies either.

Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression.

Abstract

The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11.
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(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor.

Abstract

A novel steroid compound, (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), was found to be a partial agonist of the androgen receptor (AR) in an androgen responsive element (ARE)-luciferase reporter assay. YK11 accelerates nuclear translocation of AR. Furthermore, YK11 does not induce amino/carboxyl-terminal (N/C) interaction and prevents 5-α-dihydrotestosterone (DHT)-mediated N/C interaction. Thus, YK11 activates AR without causing N/C interaction, which may in turn be responsible for the partially agonistic nature of YK11 observed in the ARE-luciferase reporter system. YK11 acts as a gene-selective agonist of AR in MDA-MB 453 cells. The effect of YK11 on gene expression relative to that of androgen agonist varies depending on the gene context. YK11 activated the reporter gene by inducing the translocation of the AR into the nuclear compartment, where its amino-terminal domain (NTD) functions as a constitutive activator of AR target genes. Our results suggest that YK11 might act as selective androgen receptor modulator (SARM).
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I can get 500 mg of it but I have no idea how much I would take...
 
Pass on mk677. The injectable ghrps/ghrhs are superior but overall just go with legit pharmacy grade hgh. .
 
Partial agonist just turns me off to the idea though once human studies are done I'll look into more. I don't like being a guinea pig
 
Partial means it doesn't fully activate the receptor so my brain goes to comparing buprenorphine to heroin. As for its myostatin inhibiting property it better be strong as we just use more steroids to temporarily push past it then cruise for a bit to allow it to lower though myostatin really comes into play mostly for the pros and not people like us.
 
Serotonin101 said:
Partial means it doesn't fully activate the receptor so my brain goes to comparing buprenorphine to heroin.
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But can't the partial agonism be attractive due to the lowered incidence of side effects?

Serotonin101 said:
As for its myostatin inhibiting property it better be strong as we just use more steroids to temporarily push past it then cruise for a bit to allow it to lower though myostatin really comes into play mostly for the pros and not people like us.
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Well, it is stronger than DHT...

yk11sarm.gif
 
Fractality said:
YK-11:

Novel steroidal selective androgen receptor modulator (SARM). Partial agonist of the androgen receptor. Significantly upregulates expression of follistatin (Fst), a myostatin antagonist.

MK-677:

Synthetic growth hormone secretagogue. Increases serum insulin-like growth factor-1 (IGF-1).


Does anyone have experience with either one of these?

I'm most intrigued by the YK-11. I can't find any info about its recommended dosage/protocol.
Click to expand...

id stay away.. play it safe.. use what the community knows to be good.. not expensive experimentals
 
I always wait when new SARMs come out to see what the real deal is. A while back when S4 was first released it was fantastic but it was later found to have a toxic metabolite that caused vision disturbances. It would give your vision a yellow tint in addition to making it impossible to see in the dark. What really sucked was that it would make you go blind for a good minute when going from daylight outside to the inside of a building. The first time that happened to me I fucking freaked out.
 
-Guido- said:
I always wait when new SARMs come out to see what the real deal is. A while back when S4 was first released it was fantastic but it was later found to have a toxic metabolite that caused vision disturbances. It would give your vision a yellow tint in addition to making it impossible to see in the dark. What really sucked was that it would make you go blind for a good minute when going from daylight outside to the inside of a building. The first time that happened to me I fucking freaked out.
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That sort of issue is what scares me off from being a pioneer by trying YK-11. There hasn't even been any animal studies done on it yet. It's fine though, I've still got PLENTY of natty gains to make.
 
-Guido- said:
I always wait when new SARMs come out to see what the real deal is. A while back when S4 was first released it was fantastic but it was later found to have a toxic metabolite that caused vision disturbances. It would give your vision a yellow tint in addition to making it impossible to see in the dark. What really sucked was that it would make you go blind for a good minute when going from daylight outside to the inside of a building. The first time that happened to me I fucking freaked out.
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Same reason I'm staying well clear. I expect it to be overpriced at this point anyway as it's pretty new and if rather not be a guinea pig.
 
Saw MK-677 for sale at one of these places we can't talk about.... even if I knew it was safe it's still a bit expensive.

And S-4 was crap imho. Maybe others had better experience but the vision stuff was creepy as fuck and the gains not worth it. Better off with 20mg of any of the normal orals per day (no not 20mg mtren).
 
If these sarms are available legally and not grey market you cab post a source, as long as it only sells legal supplements.

"No steroid sourcing. This applies to anything grey-market (including ancillaries) but does not apply to legal supplements such as Whey Protien, Epistaine, etc..."

I am not 100% clear on the legality of these supplements so I cannot say wether or not sourcing is allowed lol.
 
nolys;12374519[B said:
]If these sarms are available legally and not grey market you can post a source, as long as it only sells legal supplements.

"No steroid sourcing. This applies to anything grey-market (including ancillaries) but does not apply to legal supplements such as Whey Protien, Epistaine, etc..."

I am not 100% clear on the legality of these supplements so I cannot say whether or not sourcing is allowed [/B]lol.
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Who cares..? We're talking about hormones not narcotics.....

This isn't 1930's nazi germany....

I for one would like to see some of these web-sites to read what information they are actually stating about their products... If bad advice is being given, or false advertising we can best advise members.... This is a harm reduction web-site, how can we give out harm reduction info if we are censored, just because there is a price involved... No ones going to buy the shite anyway..!!!

my 2c..
 
Genetic Freak said:
Who cares..? We're talking about hormones not narcotics.....

This isn't 1930's nazi germany....

I for one would like to see some of these web-sites to read what information they are actually stating about their products... If bad advice is being given, or false advertising we can best advise members.... This is a harm reduction web-site, how can we give out harm reduction info if we are censored, just because there is a price involved... No ones going to buy the shite anyway..!!!

my 2c..
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As much as I totally agree with you, I honestly do agree, if senior mods came to the forum these people posting sources would get infracted and we would get complaints of not doing our job correctly. Maybe we should take this up with senior staff?
Or at least discuss the limitations of our sourcing rules in the mod thread?
 
I'd gladly post links to sources of just about anything (including illegal stuff), but it's against the rules so... and I think that should be legal as well...
 
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