Alprazolam (Xanax) 1-2mg is #1 as a rapid acting anxiolytic with antidepressant properties
Diazepam (Valium) 10mg is #1 as a fast acting anxiolytic & muscle relaxant with longer lasting, active metabolites
As a tolerant 200 lbs + male …..I would use both together in an anxiolytic cocktail (just for my tolerance)
Methadone 100mg (potent opioid for chronic pain)
Ritalin (Methylphenidate) 50-70mg IR (dopaminergic stimulant to enhance opioid analgesic and maintenance mental alertness & cognitive function)
Alprazolam (Xanax) 1mg
Diazepam (Valium) 10-30mg
Pregabalin (Lyrica) 300-450mg an effective anxiolytic & anticonvulsant compound used for neurological pain, RLS, anxiety, etc
Clonidine 0.1mg tablets - Very effective rapid acting anxiolytic & sedative, reduces Norepinephrine in CNS reducing HR & BP …..actually just as effective as any Benzo at reducing anxiety, calming everything down, and potentiates any opioid and Benzo
For a non tolerant patient……an option could look like,
Diazepam 5-10mg
Alprazolam 0.5-1mg
Pregabalin 75-150mg
Clonidine 0.1mg (half a scored tablet) …..all together, would be a god send for a mental breakdown or intense panic attack.
I personally would pulverize all tablets into fine powder, empty Pregabalin powder too, and put into large jel cap …..my own compounding pharmacy creation for myself, labeled Anxiolytic #1 in small plastic bag from crafts shop with 10 capsules inside, I compounded myself
I have certainly formulations for different uses …..Brompton Cocktail

oral Speedball, which is Opioid, Stimulant, Benzodiazepine, and Gabapentinoid ….Ethanol / alcohol & tobacco always is present when onset of cocktail taking place, and duration of main effects, usually 3-6 drinks and 7 cigarettes or so