Benzos xanax potentiation

[JackBurton89]

grapefruit juice?

 

[Lorne???]

yeah i use tagamet but it really doesn't affect the potentiation one way or the other

What doses of cimetidine? Because I just found a study where therapuetic doses of cimetidine (300mg TID or so) increased half-life from 12 to 18 hours, and a slight increase in Cmax, IIRC.

Imagine what the large doses used for potentiation could do!(1 gram, or so.)

But studies aside, I've used GFJ with alprazolam, and didn't notice much difference, now GFJ and cimetidine combined increases duration but the difference isn't as dramatic as with methadone or clonazepam.

BTW, Xanax bioavailability is 85-90%. The reason WGJ doesn't help as much is because moderate doses of WGJ only effect intestinal P450 isozymes. However, very large doses of juice(a half gallon... or... so) also inhibit hepatic P450. This still won't up BA much since it's near 100% to begin with, but it will increase half life(particularly combined with cimetidine.) Also drug synergy works quite well with benzo's as well.

 

[Lorne???]

White grapefruit juice and cimetidine both inhibit cytochrome p450 enzymes potentiating a host of drugs, xanax being among them. I'd suggest taking the xanax sublingually yes it tastes horrible but unfortunately that's life.

Personally when I used to try this the difference was negligible and didn't seem worth the cost of the Tagamet. GFJ however is delicious and is never a waste of your hard earned dollars.

I've found dxm polistirex to potentiate almost everything my memory is hazy on whether it's worthwhile for benzos, but it certainly couldn't hurt. Try dosing 60mg BID and see where it takes you.



I think Bob suffered a minor stroke or light neural spasm here I can't activity streamstand his post.

I wouldn't recommend alprazolam sublingually, unless you want a longer duration.

The sublingual Tmax averages 2.5 hours, vs 1.5 hours for oral.

Also, Cmax from sublingual is lower. However, the half-life is increased.

 

[Numb19]

White grapefruit juice and cimetidine both inhibit cytochrome p450 enzymes potentiating a host of drugs, xanax being among them. I'd suggest taking the xanax sublingually yes it tastes horrible but unfortunately that's life.

Personally when I used to try this the difference was negligible and didn't seem worth the cost of the Tagamet. GFJ however is delicious and is never a waste of your hard earned dollars.

I've found dxm polistirex to potentiate almost everything my memory is hazy on whether it's worthwhile for benzos, but it certainly couldn't hurt. Try dosing 60mg BID and see where it takes you.



I think Bob suffered a minor stroke or light neural spasm here I can't activity streamstand his post.

In normal quantities yes, however, with the amount you need to ingest to maximize the inhibition renders it barely tolerable.

That and it typically is dirt cheap. Sometimes even cheaper than bottled water.

 

[Lorne???]

In normal quantities yes, however, with the amount you need to ingest to maximize the inhibition renders it barely tolerable.

That and it typically is dirt cheap. Sometimes even cheaper than bottled water.

Haha, you really hate that juice don't you man!

That will be you're "intervention". If you get to bad on opioids, we'll sit you down and make you drink gallons of the stuff until you promise to never touch oxy again!

 

[JackBurton89]

I just tried to drink it this morning and i probably got down 24 oz. It is very hard for me early in the morning when my stomach is empty. Luckily I was able to fall asleep for another two hours then dosed 30 mins later.

 

[heromethampheTHC]

Verapamil is a drug for migraines that increases plasma concentrations of xanax and lengthens it's duration. Take around 60 mgs 45 mins before dosing your xanax. Verapamil alone may slightly sedate you, but when the xanax hits, 1 mg feels like 2 mgs! Also, a moderate (900-1500 mgs) dose of neurontin or 150-600 mgs lyrica 1 1/2 hours prior to the xanax dose helps a lot. Take essential fish oils or other proteins to boost the neurontin as well (co-administered). All an all you should get a nice euphoria and longer buzz than just 1 mg xanax alone for sure. If you smoke marijuana, a bowl pack prior to xanax' peak effects should top off a pleasant time (6 hours duration of xanax) Try it!

**p.s. - crush the xanax and scoop into a capsule for a possible 8 hour duration as an added bonus**


-Josh