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worst drug combination

Meth and mushies was pretty fucking terrible.

I also disliked meth and heroin, I don't know, there's something about the meth keeping you alert while your brain slows down that's just really uncomfortable.
 
One day I took some fluoxetine (SSRI) with my daily dose of cannabis... I ended up totally psychotic. This was the end of my 15 years love affair with cannabis. So all in all maybe it was not so bad... afterwards :X

I sometimes used to take little amounts of alcohol with my cannabis, and I liked the feeling. But I don't like alcohol too much, so I maybe did the combo like 10 times or less during all these years.

And for the OP question, I'd say methadone and subutex (or suboxone for the Americans). DO NOT take subutex if you're on methadone, it will end up in intense withdrawals due to the semi-antagonism of buprenorphine.
 
I've found K to be great on anything save one thing: Tigan suppositories. A friend and I both took ~20mg/kg of body weight IM and had used some Tigan suppositories along with some OC's as we were both fairly opiate naive and got nauseous easily. I'd taken Tigan and opiates many times, we'd both taken Ketamine w/ opiates before.

Despite dose size, no K-hole, just raging loud ringing noise, extreme size distortions, and overwhelming fear, followed by malaise.

Finished K off days later it was fine.
 
reading the thread, it appears stimulants and alcohol come out on top as the worst drugs to mix with. fine by me, i hate those drugs. stims make me feel like a zomby, i can only lay down in bed with racing thoughts and no sleep. a little alcohol before bed is alright though, if i have some headphones/music

my worst combo... weed and ecstasy. surprisingly. if i smoke weed during an ecstasy high or especially afterwards, i feel like SHIT
 
amphetamines/meth amphetamines on potent psychdelics =/, talk about over analaysing the unexplainable experiences putting yourself in a massing loophole for the rest of the long long duration haha
 
I have accidentally mixed some shit up that should NOT have been mixed up. Suboxone + MDMA is an awful mix. It puts you into immediate, hardcore opiate withdrawl and since the bupe is blocking opiates, you can't just dose on some dope to get out of it. Even 24-48hours after dosing the suboxone, it's still in your system and it'll still fuck with you when you're trying to roll, every single time.

I thought cocaine + LSD was a fun combination. It always got me high as a kite on cocaine and it made the trip even more intense for about 30 minutes. After 30 minutes, you begin to come down on the yayo and that comedown triggers the LSD comedown a bit.

I ate an 8th of mushrooms and went to go see Bruno when it came to theaters, unaware of what the movie was about. There was so much dick in that movie, and the mushies made it so 3-dimensional that the dick was coming out of the movie screen and the dick harassed me. Very unpleasant.

Meth is just a shitty drug to begin with, so anything other than a benzo with meth is going to suck like Meth+Cocaine, Meth+psychedellics, Meth+anything not a benzo is going to suck long and hard.

Benzos and uppers appear to be made for each other in all of my experience as a sensationalist. Very pleasant combination right there.

DMT+Alcohol were not made to be mixed at all and I don't see that combination ending well. Ketamine and meth seems like a really bad combination as well. Being completely dissoriented and fucked up on K plus increased heart rate and increased energy sounds like a heart attack or a stroke to me.

edit: Someone above this post said Ecstasy + Marijuana is a bad combo for them. I always avoid smoking weed when im rolling on MDMA or MDA. It usually makes me peak really hard seconds after smoking and then when I come down from the weed I also come down from the ecstasy. That could be way you feel like ass
 
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