Unlikely, just like when you take MDA, taking MDMA the next day does not result in any real loss in effects.
Just keep your dose as a standard effective dose, for my body weight its 120mg 6-APB, and 140mg MDMA, followed by 60mg.
The cross tolerance is in fact quite minimal according to all my research and personal experience.
Just be mindful that you may not find the experience as interesting or novel, which really is not really a simple pharmacological action.
Honestly, the actual action of MDMA takes around 14 days to fully return.
Sasha did a saturation study of 4 days 120->160mg MDMA daily. Then waited two weeks for essentially all full effects to return.
Those pharmacology notebooks on Erowid are gold!