Misc will phenibut raise tolerance to lyrica? both gaba

[duneplanet]

I am withdrawing from benzos and take lyrica everyday at a dose of 225 mg. My questionis i ordered some relax-all with phenibut and if I were to take it a few times a week would it make my lyrica ineffective? It is helping me and i don't wanna mess it up but somedays I need something extra. I don't plan on taking the phenibut everyday

 

[Cane2theLeft]

Phenibut is a GABA-b agonist and Lyrica is a gaba analogue so I doubt it, they have different mechanisms of action but maybe someone can shed more light on this.

 

[Mr Blonde]

There might be a partial tolerance. Pregabalin has a few different mechanisms of action, one of which is increasing the amount of GABA in the brain, so part of it's effect is due to that neurotransmitter.

Phenibut is a GABAB receptor agonist, so by causing a down-regulation of that receptor some of the GABAB modulated effects of pregabalin might be reduced. However, the effects of pregabalin that are due to voltage-dependent calcium channels and the reduction of other neurotransmitter levels may not be effected.

 

[duneplanet]

the effects might be reduced just while on the phenibut? or after it is out of my system?