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Benzos Will grapefruit juice potentiate klonopin or not?

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poppyplanet

poppyplanet

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I still haven't came acrossed a straight answer. Some say it does some say it doesn't? Thanks in advance.
 
Captain.Heroin said:
Wrong, temazepam is not. Most benzos are, you are right, just not *all* of them. :)

If temazepam *was* boosted by WGFJ you know I'd be like PRAISE JESUS! :D

Alas...I save WGFJ for diazepam.
Click to expand...

youre right, they dont list temazepam specifically in that table. But so many of those benzos are metabolized by 3a4 that I went ahead with the blanket statement...but alas, no praising of white grapefruit jesus when you take restoril.

Whats temazepam metabolized by? 2d6?
 
Captain.Heroin said:
Wrong, temazepam is not. Most benzos are, you are right, just not *all* of them. :)

If temazepam *was* boosted by WGFJ you know I'd be like PRAISE JESUS! :D

Alas...I save WGFJ for diazepam.
Click to expand...

OK let me get this straight....diazepam is potentiated by grapefruit juice right? And if so, whats the correct procedure, ie should the GFJ be taken about 20 mins before the diazepam? Or should the GFJ be taken after the diaz?

Also lorazepam (Ativan), does GFJ potentiate this benzo too?

Any advice/info most wewlcome,regards Levvytation:)
 
Levvytation said:
OK let me get this straight....diazepam is potentiated by grapefruit juice right? And if so, whats the correct procedure, ie should the GFJ be taken about 20 mins before the diazepam? Or should the GFJ be taken after the diaz?

Also lorazepam (Ativan), does GFJ potentiate this benzo too?

Any advice/info most wewlcome,regards Levvytation:)
Click to expand...

1) Yes, 2) before, and 3) no, it is another exception.

;)
 
Some benzodiazepines are metabolized by CYP 3A4, and their levels
may be increased by CYP 3A4 inhibitors, such as protease inhibitors,
causing excessive sedation, or respiratory depression.

The following are contraindicated in combination with protease inhibitors:
midazolam; triazolam.

The following should be used with caution in combination with protease
inhibitors: alprazolam , flurazepam , estazolam , diazepam , clonazepam.

The following are metabolized by glucuronidation and are free of drug
interactions with inhibitors of CYP 3A4: lorazepam, temazepam, and
clorazepate

http://www.columbia.edu/~fc15/Drug%20Interactions.pdf
(page 7)
 
I have read some reports that say yes and some that say no. All require Medline, so take my word that the information seems to be conflicting.

It was never mentioned in my Rx instructions for clonazepam. It is for both diazepam and alprazolam.

Also personal experience: negative.

Diazepam and alprazolam on the other hand - yes, to the point where I have to be careful to have one small glass or less. GFJ is a part of my diet aside from benzodiazepines, love the stuff :) But more than 1 glass, especially of white GFJ, and I notice a marked increase in sedation, amnesia, and motor impairment. In me, this is more pronounced w/alprazolam, which I no longer take daily.

I used to think the interaction was an urban myth. Nope!

I will generally take my meds with a glass of juice, and I have no reference point as to time, so I have never been able to tell if it also increases duration. I also don't take benzos for other than medical reasons at this point in time.
 
chemanthonys69 said:
Personal experience.. Kinda.. You have to drink the juice like thirty min before hand though. it gives me spectacular heart burn and really isnt worth chuggin a liter of Ruby red.... Just take two fuck it.
Click to expand...

Ruby Red grapefruit juice isn't 100% WGFJ, which is why you have to drink more (but a whole litre sounds like a lot still).

If you don't want to drink WGFJ, try cimetidine.

Potentiating one dose of benzos is more euphoric/less sedating than taking 2x as much.

BollWeevil said:
The following are metabolized by glucuronidation and are free of drug
interactions with inhibitors of CYP 3A4: lorazepam, temazepam, and
clorazepate

http://www.columbia.edu/~fc15/Drug%20Interactions.pdf
(page 7)
Click to expand...

Thanks for sourcing that BW! I had no idea lorazepam wasn't boosted by WGFJ/cimetidine. However I never tried combining the potentiation with lorazepam, so now I know to save it for diazepam.
 
One more thing, say I take 8mg of xanax is my regular dose, how much less xanax and how much grapefruit juice should I have to promlong my xannies. I just bought two grapefruits and I dont know how to use them to make my xannies last longer(as in having to take less xannax coz of the juice, not neccessarily to make the effects stronger)

Do you guys know what I mean?
 
the_ketaman said:
One more thing, say I take 8mg of xanax is my regular dose, how much less xanax and how much grapefruit juice should I have to promlong my xannies. I just bought two grapefruits and I dont know how to use them to make my xannies last longer(as in having to take less xannax coz of the juice, not neccessarily to make the effects stronger)

Do you guys know what I mean?
Click to expand...
I know what you mean. I can't help you though as I have no benzo tolerance.

I only take like 0.5mg of alprazolam as is, with or without WGFJ. So maybe you want to just take your regular dose of 8mg, or maybe 6mg and see where it gets you with the WGFJ beforehand? And then you can save up another 2mg bar for afterwards or to boost it if you aren't getting the full effect. I really don't know though, I've never had to take 8mg of alprazolam. That would fuck me up so hardcore lol. The most I have had is 1mg and I probably didn't need to take that much either.

However for diazepam - I take 5mg with WGFJ, or 7.5mg without it.

So without my tolerance factored in, maybe you could try 6mg and see where it gets you. Save another bar for a rainy (OR snowy, in my case :| *brrr*) day. :)
 
GFJ and xanax

I find that if I'm running out or in dire straits with my xanax supply that I can ward of the 'drawls very well by eating a grapefruit and taking a very small amount of xanax. Where I might take 2mg a day I can make a single 1mg pill last 4 days this way if necessary. Besides, I suggest developing a taste for grapefruit, cause it's awesome once you start to like it if you don't already. You weren't born liking beer either. Doesn't matter if gfj is taken before or after consuming the med, just at or around the same time is all that matters.
 
From personal experience, yes, but not as much as alcohol does. I had to buy a large bottle of grapefruit juice and drink it all to notice any potentiation in the clonazepam.
 
It is, or should be. Try it for yourself. I think people react to the combo / notice it, differently. To me, it doesn't make a huge difference. WGFJ is not cheap, at least not here or not to me. The limited effect/difference in taking it w/ or w/o it doesn't justify my buying it. But, like I said-try for yourself. You've got nothing to lose (except money...haha).
 
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