Will 2C-C deplete the entactogenic effect of MDMA the following evening?

[cliff.huck]

My understanding is that as a serotonin receptor agonist 2C-C should not cause any issues associated with serotonin depletion that is typically felt in 2-nights of back to back MDMA use. However, I am curious if the often reported "loved up" or entactogenic effects of 2C-C would diminish those same feelings the following evening when taking MDMA.

Has anyone had any experience with using these two so closely together? There was mention in the Big Dandy 2C-C thread of this in the opposite order--the possibility of MDxx use earlier in the week diminishing the perceived entactogenic effects of 2C-C. However, this was more of a question/guess. Also, since the the entacogenic effects of 2C-C are typically reported as "mild," I am curious if taking the stronger feeling MDxx second instead of first will ensure an equally or more pleasant effect the second evening.

 

[Morninggloryseed]

Hmmm, I did once insufflate 80mg of MDMA after a 2C-C experience. I have never taken so little MDMA before (all of my MDMA experiences have been with pure racemic MDMA, or S-MDMA...always above 100mg) so I can't say for sure how much the 2c-C affected it...but it seemed quite normal to me.

 

[kong]

^How was the S-MDMA? Missing something or worth seeking out?

I've done mdma the night after a 2c-b trip. Worked perfectly fine.

 

[Delsyd]

if i remember correctly i remember MGS saying he prefered the racemic.

Cliff.Huck, there shouldnt be much tolerance if any.

 

[alantis360]

yea you might just be drained out from the 2c c though.

 

[psood0nym]

There was a thread comparing 2C's with MDMA not to long ago. A study was linked to that showed some 2C's (not sure if 2C-C was among them) are mild releasers and re-uptake inhibitors of dopamine, serotonin, and noradrenaline (like MDMA). They're of course not nearly as powerful as MDMA, but using 2C-C the night before could slightly deplete your reserves and make things less euphoric; I doubt the difference would be very noticeable though.

 

[eatcod]

There was a thread comparing 2C's with MDMA not to long ago. A study was linked to that showed some 2C'sare mild releasers and re-uptake inhibitors of dopamine, serotonin, and noradrenaline

any chance you can point me in the direction of that?

 

[psood0nym]

^

We developed a reproducible, simple, and small-scale method for determining the re-uptake and release of monoamines (dopamine, serotonin (5-HT) and norepinephrine), using rat brain synaptosomes. These assays were then applied to study the effects of different kinds of nonmedically used psychoactive drugs on monoamine re-uptake and release. The phenethylamine
derivatives, 4-fluoroamphetamine, 2-methylamino-3,4-methylene- dioxy-propiophenone (methylone), 1-(1,3-benzodioxol-5-yl)-2-butanamine (BDB), and N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), had strong inhibitory effects on the re-uptake of dopamine, 5-HT and norepinephrine. 4-Fluoroamphetamine, methylone and BDB also strongly increased the release of the three monoamines, but MBDB increased 5-HT and norepinephrine
release, but had little effect on dopamine release. However, 2,5-dimethoxy-4-
iodophenethylamine (2C-I), 2,5-dimethoxy-4-ethylphenethylamine (2C-E), 2,5-dimethoxy-4-chlorophenethylamine (2C-C), 2,4,5-trimethoxyamphetamine (TMA-2) and 2,4,6-trimethoxyamphetamine (TMA-6), which are methoxylated phenethylamine derivatives, slightly influenced the re-uptake and release of monoamines. α-Metyltryptamine (AMT), a tryptamine derivative, was one of the strongest re-uptake inhibitors and releasers of the three monoamines. The tryptamine derivative, 5-methoxy-α-methyltryptamine (5-MeO-AMT), also
strongly inhibited re-uptake and increased the release of the three monoamines. N,Ndipropyltryptamine (DPT), 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), 5-methoxy-N,N-methylisopropyltryptamine (5-MeO-MIPT), and 5-methoxy-N,Ndimethyltryptamine (5-MeO-DMT) inhibited monoamine re-uptake, but had few effects on monoamine release. 1-(3-Chlorophenyl)piperazine (3CPP) and 1-(methoxyphenyl)piperazine (4MPP), which are piperazine derivatives, inhibited monoamine re-uptake and accelerated their release. The results suggest that some designer drugs strongly act on the central nerve
system to the same extent as restricted drugs.

http://www.drugs-forum.com/forum/local_links.php?action=jump&id=1255&catid=18

 

[eatcod]

fantastic document, thanks!