Why Parkinson's medication don't give Paranoia?

[Davevanza]

Hi,

I ve been thinking about this.

Many people develope Scizophrenia, Psychotic symptoms, while on Medications that increase our Dopamine in the brain.

So, there antipsychotics are prescribed to block the Dopamine (D2) Neurotransmitter.

Now, my question is :

Why do those people who suffer from Restless Leg Syndrome and Parkinson's Disease do not suffer from Psychosis?

( Those medications, actually increase our brains' Dopamine.)


Thanking anyone in advance who will give his opinion on this subject.


Kind regards,
Davevanza

 

[Divine Moments]

Dopaminergic drugs (such as those used in Parkinson's Disease) can and do cause psychosis in some patients. Not all that uncommon from what I've heard.

 

[Davevanza]

Hi,

I see.

So it could actually cause Psychosis.


I would like to try L-Dopa, and Amantadine.


Has anyone got any advice for this?


I appreciate it.

Kind regards,
Dave

 

[Davevanza]

But, I am still not fully convinced, as I work in Hospital, seeing Elderlies with Alzheimer's Desease, Parkinson Disease etc

None, it's none, not even 1 of them develop this.

I , then ask the Proff ( Neurologist), and he just is confused too.

And in the book " SMART-DRUGS" by Morrganthaler, he tried L-dopamine himself. He described is " Horrible"

Even Selegiline, The Patent one, he said do not gibe the same effects as in the liquid form, that he gets from somewhere ( I forgot)

You can Google about Morganthaler and Dopamine

So any input ?


It's gratly appreciate it.

Kind regards,
Davevanza

 

[Mr Blonde]

You probably don't see it in hospital because these patient's serum drug levels are being monitored closely and their reactions carefully monitored.

These drugs can and do cause psychosis and other issues, particularly if there is an overdose. Anecdotally, I read a post on another message board (Snopes) recently in which the poster was talking about a mix-up with her father's anti-Parkinson's drugs leading to a protracted period of psychosis.

Another factor to consider is that incidence of psychosis may be lower in this population because of the disorder of their dopamine system; the risk is still there, but decreased due to a lesser dopamine response.

Why are you considering taking L-Dopa and Amantadine?

 

[Davevanza]

Amantadine and L Dopa

You probably don't see it in hospital because these patient's serum drug levels are being monitored closely and their reactions carefully monitored.

These drugs can and do cause psychosis and other issues, particularly if there is an overdose. Anecdotally, I read a post on another message board (Snopes) recently in which the poster was talking about a mix-up with her father's anti-Parkinson's drugs leading to a protracted period of psychosis.

Another factor to consider is that incidence of psychosis may be lower in this population because of the disorder of their dopamine system; the risk is still there, but decreased due to a lesser dopamine response.

Why are you considering taking L-Dopa and Amantadine?

Well, honestly, I thought that by increasing the Dopamine level could give a better feeling.

But since I read, from Morganthaler's experince, I might forget about L-Dopa.

Amantadine? I never try it.....
I may one day ask a GP for it..

Is it sedating, or kind of stimulant?

 

[footscrazy]

There's also 4 different kinds of dopamine receptor with different effects - I think antipsychotics like seroquel bind to a different dopamine receptor than the one that is agonised by something like methamphetamine. This is what I found when I was researching whether low dose seroquel would work to lower meth tolerance in the same way naltrexone lowers opie tolerance. Also, whereabouts in the brain the dopamine is released makes a big difference on its effect. A friend tried L-Dopa once and found it really unpleasant.

I don't think 'increased dopamine causes psychosis' is anything more than a theory anyway. It does look like it plays a role but it's probably a lot less straightforward than that.

 

[Mr Blonde]

I don't think 'increased dopamine causes psychosis' is anything more than a theory anyway. It does look like it plays a role but it's probably a lot less straightforward than that.

Definitely true; although dopamine is clearly involved in the mechanism of psychosis, there is still little understanding of the true cause and effect relationship that is going on in that situation.

Well, honestly, I thought that by increasing the Dopamine level could give a better feeling.

But since I read, from Morganthaler's experince, I might forget about L-Dopa.

Amantadine? I never try it.....
I may one day ask a GP for it..

Is it sedating, or kind of stimulant?

Using L-Dopa won't make you feel good simply because you are raising dopamine levels. As footscrazy said, dopamine has many different functions throughout the brain and body and disrupting this can lead to many different side effects. Clinicians use L-Dopa carefully in Parkinson's therapy due to the risk of causing dopamine dysregulation syndrome.

If you want to improve your mood, have you tried taking l-tyrosine or 5-HTP or other precursors essential to neurotransmitter production?

As for amantadine, it would be more of a stimulant but not in a good way it sounds like. Here is the list of side-effects, with frequency of 1-10%.

Agitation

Anorexia

Anxiety

Ataxia

Confusion

Constipation

Depression

Diarrhea

Dizziness

Dream abnormality

Dry nose

Fatigue

Hallucinations

Headache

Insomnia

Irritability

Livedo reticularis

Nausea

Nervousness

Orthostatic hypotension

Peripheral edema

Somnolence

Xerostomia

<1%
Amnesia

CHF

Decreased libido

Dyspnea

Eczematoid dermatitis

Euphoria

Hyperkinesis

Hypertension

Instances of convulsions

Leukopenia

Neutropenia

Oculogyric episodes

Psychosis

Rash

Slurred speech

Urinary retention

Visual disturbances

Vomiting

Weakness

Sounds like it should be best left to clinical use and not self-experimentation.