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Bupe Why is the BA for bupe higher intranasal than sublingual?

suessmayr

suessmayr

Bluelighter
Joined
Jun 30, 2008
Messages
1,067
Location
Sydney, Australia
I don't get it. Insufflation just sends a good part of what you sniff back down your throat and into your stomach, where it is obviously destroyed. Is the idea to sniff it but not too hard, so that it doesn't go straight down your throat? Or should you cut it heaps coarsely so that it doesn't just go right down?

Or is Wikipedia just full of shit in saying that intranasal has a higher BA than sublingual?
 
When you sniff it, it is absorbed by your nasal membranes. It's only when you sniff too much too fast that some of it ends up dripping down your throat.

Sniffing smaller amounts softly allows for it to be absorbed by the nasal membranes, which has the higher BA than sublingual in the case of bupe.
 
So with suboxone 8mg tablets, how small would a line have to be for it to not just become drip? Is 2mg too much?

Also, does the amount of food in your stomach affect absorption of the bupe when taken intranasally? What about sublingually or IV?
 
Bend over please sir and drop your trousers

It follows then that an 8mg be split into 16 lines...? Christ, that's a full time occupation. The 'sticking it up the richter' option seems more and more attractive.....!
 
Most people only sniff 1 or 2 mgs. If you read through the suboxone megathead you will see that most people prefer doses that low since euphoria doesn't really increase much at higher doses. Also, I thought that the suboxone strips had replaced the pills, so I don't know if the size of lines will still apply. I would think that the strips need to be dissolved into a solution and dripped into the nose. I don't sniff suboxone so I don't know, but I'm sure the info is all over here if you search.

As for stomach contents affecting the high when using ROAs other than oral, I think that eating things like cimetidine to potentate the high still works.
 
Yeah whenever I'd take intranasal bupe it'd be using an N8 pill and breaking it down into 1mg pieces. Then each 1mg piece turns to 2 lines. I never use or have used bupe recreationally, but I was able to use them to help quit my oppie habit very, very reasonably by dosing nasally.

IMO not to pleasant up the nose though... and a weird orange-y tasting synthetic drip.
 
Intranasal bupe works best. Hits faster and is most definitely stronger. This is the route I would use while coming off dope to get the most out of your shit. For the record, I would split an N8 into 16 0.5mg lines, and do 1-2 of them at a time, depending on how incapacitated I wanted to be.
 
When I used to snort bupe what I would do is let the drip rest in the back of my throat and then bring it back up and hold that under my tongue too. So you would get a double whammy! Not sure if its any more effective then just swallowing the drip, but I was paranoid about wasting it so I would do that.

But I never got any effects from bupe no matter what way I took it. I guess my tolerance was just wayyyyy to high for it. I take methadone now and it works much better =].
 
suessmayr said:
So with suboxone 8mg tablets, how small would a line have to be for it to not just become drip? Is 2mg too much?

Also, does the amount of food in your stomach affect absorption of the bupe when taken intranasally? What about sublingually or IV?
Click to expand...

You just have to snort a little bit at a time, then wait, then snort a little bit more. Rinse and repeat.

And no the amount of food in your stomach doesn't affect intranasal absorption. Anatomy lesson of the day: your nose is not part of the GI tract.

Subligually and IV no and no. Only oral administration will be affected by stomach contents.
 
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I'm still not clear on how intranasal can possibly be stronger if most of the bupe becomes drip. Do the membranes absorb bupe from the suboxone and then allow it to pass through? If not, then everything you feel going down your throat is going to waste. No matter how small the line or how slowly you snort there will always be drip. Either that or it will just drip back out the way it went in.
 
^ Yea, the idea is for you to keep it up there as long as possible, allowing the membranes to absorb it. You should try not to sniffle while it is up there. Also, most of the drip is likely the inactive fillers.
 
Ah I see. I have to agree that intranasal is a lot more hectic than sublingual. On the other hand, IV is way more hectic than intranasal - but I could count the number of times I've injected on one hand and don't really wanna go there. It's more a question of BA - IV'ing you'd use half as much bupe.
 
suessmayr said:
I'm still not clear on how intranasal can possibly be stronger if most of the bupe becomes drip. Do the membranes absorb bupe from the suboxone and then allow it to pass through? If not, then everything you feel going down your throat is going to waste. No matter how small the line or how slowly you snort there will always be drip. Either that or it will just drip back out the way it went in.
Click to expand...

I would imagine you're snorting too hard. Most of the time I'm impatient and just snort it all at once, but during the times I do it right, take tiny, soft bumps, and then wait a few minutes, then do it again, I can get no drip at all.
(At least if I have any it's too little to notice.)
 
The intranasal ROA is most effective when you create an optimal nasal spray solution, and use a nasal spray pump to get the drug at the ideal areas for most effective absorption.

Merely snorting 2% buprenorphine potency powder (crushed up 8mg tabs) is not going to be as effective.
 
The surface area of the sinuses is huge. There is lots of bloodflow too. Anything lost to the drip is small by comparison. You lose a lot of bupe when you swallow after it dissolves.

I've snorted 16mg, it worked. I think everyone's overestimating the drip and underestimating the surface area of the nose. There was one study that showed insufflation of a lactose 3% heroin mixture(once the average purity) was absorbed as good as 100% heroin. And when it was legal there were cocaine cotaining catarrh powders that had relatively low doses of cocaine, like 200mg-500mg an ounce, that cokeheads would abuse and get hooked on.
 
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