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Heroin Why is methadone withdrawal far worse than heroin withdrawal?

Zopiclone bandit

Zopiclone bandit

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Had the worst few days withdrawal due to suddenly losing my script of 50mg of methadone and the withdrawal is far worse than heroin, it's like a full blown heroin detox feeling but even worse in the effects, why is it so bad?
 
I try to be Stoic as possible but I can understand why a person may wish to end it when in a full blown methadone withdrawal, it's worse than any heroin withdrawal I've ever known.
I've just had bag of Afghanistan heroin and I'm still not feeling well, methadone is poison and my advice is NEVER get a habit on this stuff, I've never been this sick in my life.
 
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When you get a chance and some disposable income, you could investigate this practical recovery guide. It will mitigate the negative effects of methadone ("harm reduction"), potentiate the methadone and help reduce/reset tolerances. If you want to actually stop taking methadone, it'll reduce WD's, prevent relapse and basically facilitate full recovery. All without using expensive or experimental items.

KurtAurelius said:
Methadone has other activity aswell, NMDA antagonism but also inhibition of Norepinephrine and Serotonin.
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Don't forget the TLR4 thing. All opioids activate TLR4 which causes many issues including wd, tolerance and habitual reuse.
 
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As mentioned methadone is very potent and has a long half life.

Chronic use wise at doses equivalent to 300mg morphine or more then methadone ends up being 6x - 20x more potent than morphine and it builds up in the liver and fatty cells, so it slowly releases out of them, causing full blown withdrawal that lasts around 4 weeks and Post-Acute Withdrawal Syndrome (PAWS) that lasts months to years depending on how long you've been using and if you've weaned off or went cold turkey!

If you have the spare cash once you get sorted make sure you have a stash to fall back on in case you ever screw up your script again or are very ill and can't pick it up.

There's sites that will supply kratom in/to the UK and apparently have had zero problems with dried leaf material.

Any strong full agonist you're not gonna take whilst bored is good back-up.
 
Gaz_hmmmm said:
ends up being 6x - 20x more potent than morphine and it builds up in the liver and fatty cells, so it slowly releases out of them, causing full blown withdrawal that lasts around 4 weeks and Post-Acute Withdrawal Syndrome (PAWS) that lasts months to years depending on how long you've been using and if you've weaned off or went cold turkey!
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My God, PAWS that lasts months!!!!!!!

How sick I felt yesterday was a BRUTAL LESSON, I'll never look upon being Heroin sick the same way again. I have had so many times dope sick but from simple Heroin withdrawl, I've only been on a Methadone script since early this year & yesterday was the first time I have felt the Wrath of Methadone.

I kept on vomiting but worse than heroin withdrawl, every single part of my body HURT, when the cat walked on my legs with it's little tippy-tappy paws it felt like I Was being crushed, if I had to deal with several weeks of that I would 100% think about jumping off a bridge as it will be more easy that dealing with it.

Who the hell first made Methadone in the first place?
 
Zopiclone bandit said:
Can you put that in simple words please, I don't understand what that 100% means.
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It's like taking heroin (full agonist opioid), and a drop of DXM or ketamine (NMDA) and also a drop of an anti depressant like Prozac (SSRI)... not just an opioid.

To somewhat oversimplify

So the combined withdrawals are brutal. SSRI withdrawals on their own are pretty rough.
 
RedRum OG said:
It's like taking heroin (full agonist opioid), and a drop of DXM or ketamine (NMDA) and also a drop of an anti depressant like Prozac (SSRI)... not just an opioid.

To somewhat oversimplify

So the combined withdrawals are brutal. SSRI withdrawals on their own are pretty rough.
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I understand that 100%.
I have experience with all those drugs.
 
Zopiclone bandit said:
Can you put that in simple words please, I don't understand what that 100% means.
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Apologies for that

(Edit also seen people have already explained more than adequately too!)

Basically it just has additional activity in the brain than normal opioids, meaning it causes a nastier withdrawal unfortunately in your case.

The 2 bags of H won’t touch the other chemical imbalances your experiencing alongside not being able to touch the extra tolerance built from the Methadone.

NMDA antagonists are commonly drugs like Ketamine etc.

The Norepinephrine and Serotonin inhibition would be similar to SNRI antidepressants like Venlafaxine which is reported to have a nasty withdrawal,

Tramadol is a opioid with SNRI activity as another opioid example which is known to have a nasty withdrawal.
 
Zopiclone bandit said:
Who the hell first made Methadone in the first place?
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The allies grabbed the patent after beating the nazis I believe.

The interest came from the additional activity being theorised to be a stronger painkiller, alongside causing less euphoria and other side effects.

It then became a maintenance drug due to its half life, but i believe it’s a very poor option.
 
KurtAurelius said:
Apologies for that
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No need, it's my lack of education that caused the issue, I did Google it but I still couldn't understand what was being said.
When it comes to "drug chemistry" my limit is buying RC's & reading Erowid sadly.

KurtAurelius said:
Tramadol is a opioid with SNRI activity as another opioid example which is known to have a nasty withdrawal.
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I have heard that so many times, I never could understand why people would say they were sick off that stuff when it's given out by doctors on The NHS so easy, I don't even think it's a blue script but I may be wrong.

I always had an attitude of "How can anyone say they are sick off that, it's weak as fuck" BUT now I understand, it's not the actual "potency" of the heroin or opiate that makes you feel so ill, it's down to this SNRI activity stuff.

In a way for someone who's used Heroin since 2001 my actual understanding of how it actually works & how something like Methadone could totally floor me in withdrawl is shameful (imho)
 
KurtAurelius said:
i believe it’s a very poor option.
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No need to "believe" it's a VERY poor option, what I went through was a Living Hell.
I have done several times in UK police cells being held to go to Court as Bail wasn't granted, I have done a full 48-60 hours with nothing & then being tossed into the "sweat waggon" to go to Court & NEVER been that sick.

YET AGAIN logic isn't being used in The NHS & UK drug laws, how can Methadone be given out so easy to people who want to get clean when the side-effects are so brutal? The NHS & people at the drug rehab places MUST KNOW how bad the "sickness" is off Methadone, yet again the only logical thing to me is to give people diamorphine scripts & taper them down slowly.

When will the UK & NHS see logic & start to give us legal diamorphine scripts for God sake? I was so sick yesterday & if I have to face weeks of that......well I simply cannot face it.
Any Heroin addict KNOWS a heroin detox is over in 6 days at the worst, then you have PAWS but the actual pain, vomit, stomach issues, snot out your nose, sneezing so it burns your lungs from the violence of it etc is over quite quick, Methadone it seems you have weeks of it!!!!!!!!!
 
"No, fentanyl is not a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI).
Fentanyl is a high-potency, synthetic opioid analgesic that works primarily by binding to mu-opioid receptors in the central nervous system to relieve pain."

Why is Fent made out to be so bad to get off if it isn't in the SNRI family?
I seen videos of people in Fent withdrawl & they looked like me yesterday, people so sick they are on the floor unable to move their legs vomiting their guts out but Fent isn't one of those fucking evil SNRI things, how bad is Fent withdrawl to methadone?
 
Zopiclone bandit said:
Who the hell first made Methadone in the first place?
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The Germans developed Oxycodone, Methadone and various other opioids during WW2 because they could not grow opium domestically nor import it. They needed a pain killer to keep their army supplied (along with the general population). They also produced a shitload of meth and sold it OTC for many years. But they had to start limiting how much you could buy OTC because so many people got hooked on it. They also had a combination tablet of meth+oxycodone that they gave to the army during blitzkrieg operations.

After the war western pharma companies stole all the research and started producing the stuff to make themselves less reliant on having to import opium for domestic morphine production.

Methadone withdrawal fucking sucks but you got this. I promise after a week you'll feel much better.
 
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