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Why is it not recommened to do high doses of some psychedelics?

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mushroomdub

Bluelighter
Joined
Sep 8, 2011
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Hello everyone.

I've got previous experience with a few different psychedelics.

I've recently acquired some 5-meo-mipt. And everywhere I read I tend to find people recommending lower doses - doses that aren't quite as 'psychedelic' as say 150ug of LSD for example.

But are these just valid recommendations? Do these substances have an larger effect on heart rate, body temperature etc? It seems this (low dosage recommendation) applies to substances like 2-CB, 5-meo-mipt, 5-meo-dalt.

Compare this to substances like 4-aco-dmt, 4-ho-mipt, 2-CE.

In my experience, a low dose of 25c-nbome had similar entactogenic effects to say a low dose of 5-meo-mipt.
On my last trip of 18mg of 5-meo-mipt things definitely started to get quite psychedelic. Same thing occurs for AMT.

I have a feeling these are just biased opinions being passed along. Essentially my question is on what basis do we/you recommend doing 'psychedelic' doses on only certain substances?

I'm considering doing a high dose (25+ mg) of 5-meo-mipt hence my concern. I've done it previously at 5, 15, 18 (these figures are +/-3mg).
 
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In particular, 5-MeO-MIPT has two "profiles". At lower dosages it acts for many as an entactogen, but I do not usually experience that effect at low dosages, and neither does my wife.

I have found dosing in the 25+mg range (and up to 60mg of the HCl salt) to be fine and without any negative physical effects, but I would sincerely urge you to continue your slow titration upwards rather than jumping straight in to higher dosages. This is subjective (as most things are), but higher doses of 5-MeO-MIPT can be "sneaky". I find most non-extreme dosages to be a very subtle experience, so it's sort of easy to miss.

I also find it to have sort of a "dark" or "twisted" tint to it, so it's not a favorite of mine. I do not think it would be the most forgiving substance to get in over you head with. It may be subtle up to a certain point, but can and will get intensely psychedelic at the higher ranges.

It has a very short onset, so I've always found it easy enough to titrate up orally once more at the 45-60min mark if needed. Of course, be careful when re-dosing! I have not personally found it to be a great idea to re-dose any substance as it generally leads to product waste (and overdose if done without care), but can be done relatively safely orally with this substance.

The trip also tends to happen in two stages at higher dosages -- starting out with euphoric and entactogenic effects, and then settling into a more traditionally psychedelic "mode" about halfway through the plateau. It's an interesting thing.


That said, that is a particular instance. Some other psychedelics can have extremely negative physical side effects at higher dosages. See the DOx series, and the Bromo-Dragonfly incident from a few years ago. Cardiotoxicity, neurotoxicity, and all sorts of bad things can happen when exceeding safe limits, or using unsafe RoA's some chemicals, even ones considered relatively safe.

Since all of these chemicals are very different and have different thresholds of safe usage, it is extremely important to carefully and diligently research each one, and continue titrating your dosage up once an allergy test has been established, as you did with the 5-MeO-MIPT. It can be frustrating to under-dose and have to wait, but it is much better than cardiac arrest because you were sent a mislabeled chemical, or simply pushed it too far.
 
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Thanks for your reply. Very informative indeed!

Interesting you mention the twisted tint. Had a very 'cartoon-ish/twisted' trip on a very large dose of AMT. My whole vision seemed to have become a 'painting' with only one object being visible which would pulsate 'energy' and 'wiggle'. Just side tracking a bit.
 
it depends on the drug

DOx series such as DOM DOI DOC etc are full agonists as are the NBOME series. this means that in overdose they are pretty harsh to your body and can kill you at very high doses (or on doses that other have been fine on, as people vary in sensitivity). bromodragonfly is a horrid vasoconstrictor but the DOx seris can that shit too so be carefull.


LSD is a very strong partial agonist hence why it is so safe in huge overdose (although very unpleasant in that scenario). cannabis (THC) is another partial agonist and a lot of the cannabis analogues that are killing people and giving them seizures have full agonist properties. full agonist drugs are generally less forgiving if you take a big overdose

AMT is a monoamine releaser and in high doses could cause problems due to that simply because its so incredibly potent i.e 5mg can be felt whereas 5mg of mdma is nothing to note in any way shape or form
 
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