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why does it seem that 2c-x compounds are better in effect for re-dosing than tryps

T

T9358

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I have noticed that with tryptamines a good solid dose up front and maybe a pre-peak booster can heighten and sustain the psychedelic effects/prolong them, but with 2c-e and alike it seems you can really draw out the experience.
Is there a rational reason for this like potency at the 5ht2a receptor/how long the compound activates it? or are tryptamines a whole different ballgame from phenyls?
 
I imagine it's as simple as tolerance. Tryptamines rapidly cause strong tolerance to build which fades quickly whereas phenethylamines build tolerance slowly which lasts longer.
 
I would imagine so, yes. And (psychedelic) tolerance in turn seems to be correlated with some other factors that may be affinity plus efficacy on the receptor and/or efficiency for the right types of downstream signal transduction. I don't know which it is, but it really seems to me like some drugs like the NBOMe's that are more potent in certain ways are able to cause stronger tolerance and much more acutely as well.
If there is a difference between typical phenethylamines like the 2C-X family, and typical tryptamines like the 4-AcO / 4-HO family - I bet it has something to do with those pharmacological differences like affinity / efficacy ratios.

It would be fun to check if I am right about the correlation, but I'm a bit too tired or lazy to do that now.
 
Re: redosing

I tend not to enjoy redosing anything but I have in the past redosed DMT...never experienced any sort of tolerance....and this was when I was a maniac with it, taking it always/often for OP WD.

The past two times I tried IMed psilocin...I took another 2hr later and never noted tolerance...if anything I could extend the trip with less.
 
I am interested in the mechanisms behind this as well.
One time I did 20mg of 2ce, the next night I did 25mg with no noticeable tolerance buildup then supplemented the second dose with another 30mg 8 hours in with a slight tolerance buildup.
With LSD however I need to wait a week to get a full trip
 
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