Why cant I feel oxy orally?

[sigley0527]

I have been taking Oxycodone daily for almost 4 years; 30mg IR, about 8 per day but could push 10-12 on really bad days. For the past 2 years I has strictly been snorting them 30mg at a time usually every 2-3 hours. Now like I said, I strictly snorts all of his oxy. Every once in a while (every few months or so) I decide to try and take it orally just to see the effects. I read that when taken orally it has a higher bio-availability. I get a decent buzz off snorting one 30mg. When I do decide to try and give the oral route a chance he is ALWAYS disappointed. I can take 3 or 4 pills (90-120mg) in one shot and NOT FEEL A THING. How can this be possible? I do not understand why I can catch a buzz off of snorting one 30mg pill (even though the buzz is very vague) but feel NOTHING when tripling or quadrupling the dose orally. Its an absolute complete waste to me to take oxycodone orally. Everyone is always saying the buzz lasts longer and feels better when taking orally but I just don't experience that. I just don't see a point of attempting to swallow 200+mg in one sitting to see if that works when I could just snort one or two and be good. I know I have a heavy tolerance, but I mean c'mon, I think this is a little ridiculous.

 

[The Doc.]

Could be psychological I remember the first time eating oxy instead if snorting I was like WTF have I been doing snorting these fucking things when I could get so much higher eating them and this was when I was a kid soi didn't know anything about B/A or that eating it has a higher Bioavailability. Lots of people report this after snorting them for so long the thing is most of the time it's cause of either the person not taking the coating off the pill or because the person is so addicted to the whole ritual of snorting one and getting that drip going down your throat and every thing knowing they will be feeling good in a few minutes when they snort can make a big difference

 

[The Doc.]

Oh ya you may want to edit out the swim parts and just put YOURSELF instead the mods don't like that and discourage it/edit posts when they see fit.

 

[Larc]

It has to do with your brains reward system. This more or less translates into a placebo effect.

I always cringe at users who snort pills, so many good drugs wasted haha, hut if it gets you off, then right on.

 

[Snakevillon]

Yea eating oxy kinda sucks I always see the people here way over estimate oxy oral ba (90%) yea right and underestimate snorting they say bout35% when in reality both moa s have large ranges in which ba usually falls oral 50-88% and nasal 40-75% so as you can see there about the same except oral averages slightly higher but that is easyly made up for with the fast absorbtion and higher peak plasma levels tht snorting gives ... First off to each there own and FYI I'd shoot em I I had em I do dope lol but ATTENTION oral oxy users get off your high horse just because you enjoy a less intense longer high does not make you better than us IV and pre IV snorting junkies

 

[The Doc.]

Haha what? better than IV users who said that? Whatever turns your crank I used IV heroin for years after snorting oxys for years and I still would never IV a oxy or snort one because I like the high of popping more it doesn't just last longer yes it kicks in about 5minutes slower than snorting(big whoop) but the high for me was more intense and you really feel the whole pill better.

But now that you mention it mabye you IV oxy users should smarten up and get some sense more intense sure but not worth the damage to veins and the shorter duration in my opinion. The oral BA is higher than snorting I don't care what anyone says haha can't convince me otherwise when I have experienced it all myself and found what worked for MYSELF you yourself found IV to be better so go ahead and IV ... Dam junkies:D

 

[sigley0527]

I've never IV'd anything before and don't plan to either. I've also never tried dope as well; even after taking roxis for 4 years straight. I've been prescribed the roxis these past 4 years due to multiple failed neck surgeries. I started snorting them a few years ago due to tolerance issues. I've really put a lot of thought into quitting the past few months and snorting them, IMO, intensifies the addiction and compulsive behavior. I find it incredibly hard to taper while snorting the doses. If I only can break the compulsive habit and start eating them I'd stand a better chance at a successful taper. But when I can triple or even quadruple the dose orally and still feel nothing I see it's going to be hard to get to a point where I'm taking one pill at a time orally for a taper. I think that taking it that way would be similar to a low dose maintenance dose of sub because I would feel NOTHING except I wouldn't be getting sick. Whenever I go on sub, either at an attempt to quit or because I run out of my supply early, I am able to get to a very low dose (1mg/day) in about a week. I know that should be equivalent to about 35-55mg of oxy per day, so my point is I know I have the physical capabilities to taper.

 

[sigley0527]

But when I could eat an entire days prescribes dose of oxy in one sitting, and feel nothing, I find it pointless when I can snort one at a time. With snorting, I'm able to take my meds as prescribed...with the exception of putting them in my nose instead of mouth lol.

 

[The Doc.]

are you taking them on an empty stomach??
somethings fucked up here if you don't feel anything

and your right you cant snort those things and taper

 

[Libertin]

If you don't feel oxycodone orally it could be that you're lacking in the CYP2D6 gene which codes for enzymes involved in metabolising many drugs including oxycodone. Intra-nasal administration can avoid the first-pass hepatic metabolism somewhat, possibly this can explain why you feel effects with this ROA.