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Why are so few people aware of Serotonin Syndrome?

blase deviant

Bluelighter
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May 9, 2004
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I was in ER the other day, and got two (very small, she didn't say how many mg, but they were definitely under 10mg apiece) shots of morphine. I was then told that was all the morphine I was allowed, but I could be given demerol.

I didn't know how much was in there, and had said earlier I didn't want it because I heard it had bad interactions with SSRIs, but hurting and wanting more opiates, and because I'd skipped my Celexa for a day now, I asked for it (later to find out it was only a 15mg ampoule, which is practically nothing, and I know it wasn't 150mg because I would've been knocked out by that + even the tiniest morphine).

I felt like crap, not immediately (I was given a percocet, still not sure if it was 5/500 or 2.5/500, it was blue like a 5, but oblong like a 2.5, and I doubt it was a 7.5 or 10, both because of subjective feelings, but mostly judging from the doses they gave me of everything else), but the next morning, I felt distinct serotonin-like symptoms of confusion, stumbling around, brightened colors and 'flashes' along with those blue spots you see. Not enough for a definite positive, but still... and this was only on 15mg (which a narcotic converter tells me = 2mg IV morphine).

This should probably be moved to drug culture, but I was interested in some of your guys take on it, and whether or not the potential for interaction between SSRIs + demerol is overstated in journal articles...
 
Well phenylpiperidine opioids and SSRIs -have- causes serotonin syndrome, but that doesn't mean that they will cause it every time, especially at low doses.
 
Hmmm... there are also reports on PubMed of oxycodone causing serotonin syndrome with SSRIs. WTF?
 
There seems to be more support in the journals for Pethidine causing serotonin syndrome in conjunction with monoamine oxidase inhibitors than with SSRI's. Although given that I found an article from Drug safety : an international journal of medical toxicology and drug experience which said "The serotonin syndrome may result from coadministration of pethidine, dextromethorphan, pentazocine or tramadol with monoamine oxidase inhibitors (MAOIs) or selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs)" it seems a bit foolhardy for them to give you that particular painkiller.
 
Ok. I was never, ever aware of ANY opioid, in conjunction with SSRIs being the possible culprit for Seratonin Syndrome (one of my greatest fears)...
Can someone please confirm whether or not Heroin/Morphine, or even buprenorphine can cause Seratonin Syndrome?
This is all news to me...
 
Pethidine/Meperidine/Demerol are all the same thing. Basically this synthetic opioid also has some affinity for the serotonin reuptake transporter "SERT" and to a lesser extent the dopamine reuptake transporter "DAT". Tramadol is a prodrug to an opioid and this too has some affinity for the SERT and also the norepinephrine reuptake transporter "NET". Certainly if mixed together, taken in high doses or taken in conjunction with other SERT inhibitors or serotonin releases then serotonin syndrome is a real possibility. I believe this condition can cause increases in core body temperature, tremor, confusion and perhaps hypertensive crisis and maybe even hallucinations, certainly amplifications in the perception of color. Quite dangerous actually
 
Yeah, I think it's just peth/meperidine. I've had DHC, vicodin, oxycontin with 3 different (well, actually 4, if you count Lexapro/Celexa as different) SSRIs, no problem.
 
i just took some E earlier and was chilling and having a good time and whatnot and so i took some 5htp when i thought i was gonna come down cause i didnt have any green which i normally smoke on the comedown. well after a while i started to feal like i was gonna puke. I only took 2 pills but they were supposed to be pretty potent an i took one around 3pm and another at 6 and now its 10 and my pupils are still fully dialated like you can hardly see the iris and absolutely everything i see gives me that deja-vu fealing and i keep reading this damn box thinking its a post and i keep throwing up and dry heaving, im confused as all hell and wish i had som ganja to mellow my head out, or at least shut it up. sound like seratonin syndrome to you guys?
 
death4funandprofit said:
i just took some E earlier and was chilling and having a good time and whatnot and so i took some 5htp when i thought i was gonna come down cause i didnt have any green which i normally smoke on the comedown. well after a while i started to feal like i was gonna puke. I only took 2 pills but they were supposed to be pretty potent an i took one around 3pm and another at 6 and now its 10 and my pupils are still fully dialated like you can hardly see the iris and absolutely everything i see gives me that deja-vu fealing and i keep reading this damn box thinking its a post and i keep throwing up and dry heaving, im confused as all hell and wish i had som ganja to mellow my head out, or at least shut it up. sound like seratonin syndrome to you guys?

It sounds to me like you're sensative to 5-htp.
 
i use to take the shit all the time when i use to do a lot of e but i havent rolled in a while and actually had no intentions of pursueing the drug, but it kinda fell in my lap so i took some, but i did fail to mention that ive never rolled without smoking green on the comedown except for this time. pretty sure the pills are legit and not meth cause my girlie is asleep right now and she took just as much as i did

nevermind, she just woke up puking, im putting my money on potent pills combined with lack of tolerance. i just hate not knowing whats in my pills, should prolly get a tester, its just hard to fork over that much money considering how rarely i roll. oh well, what doesnt kill you only makes you stronger right? figuratively, of course, as in: not gonna do THAT again. not until i get a tester
 
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