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Opioids why are benzos most commonly used to potentate opioids?

H

hdth

Greenlighter
Joined
Oct 20, 2012
Messages
32
Speaking upon experiences I know that benzos not so much potentate my high but instead add to it. opioids and benzos combined creates the feeling of no worry, euphoric happiness. They go together like bread and butter. Upon its effects on the brain something doesn't seem to add up right.

I recently read a passage of exactly how opioids effect the brain. Obviously the most common are endorphins. When endorphins are stimulated gaba is decreased as a result of gaba being decreased dopamine is released. There are other neurotransmitters involved but these are the ones that are important for the sake of this thread. So if taking benzos act upon gaba wouldn't that decrease the high as it would also mean less dopamine is released? Yet instead its just the opposite. Also, if taking opioids decreases gaba, wouldn't that mean increased anxiety in the brain? Iv never heard of anxiety while taking opioids so endorphins probably do something for anxiety regardless of gaba but how?
 
benzos lower opiates b/a. my dr. refused to rx me benzos for that reason. but if your taking high doses of opiates, they will help u nod.
 
My bad, they do "increase GABA", as others have said, since they are CNS depressants, they increase the "nod" mainly...

"Benzodiazepines work by increasing the efficiency of a natural brain chemical, GABA, to decrease the excitability of neurons. This reduces the communication between neurons and, therefore, has a calming effect on many of the functions of the brain" Wikipedia

@cory291 do you really think that's the reason your doc won't Rx you benzos...?
 
nodding out lol something iv never understood was why so many people like to take opiates just to nod out and get that opiate itch, to me thats the negatives of taking opiates. Whatever floats your boat I guess.
 
Benzodiazepines increase sedation and euphoria due to their anti-anxiety properties. It will increase the nod significantly. Short acting benzos in particular such as xanax and lorazepam, I find, produce a lot of euphoria when combined with opiates.

I must mention this combination is extremely dangerous. It can easily cause severe respiratory depression in higher doses, and the person can become cyanotic. Many people have died from this combination. If attempted, the person should have tolerance to both opiates and benzodiazepines, and lower doses of each significantly.

I don't condone doing at all though to be honest. It is extremely risky.
 
^ I agree, for me over sedation isn't extremely recreational in my opinion, but with slightly more stimulating opiates ei oxycodone, for me, it is enjoyable to ingest a small amount of a benzo. I do agree though, traditional opiates like morphine are sedating enough on their own.
 
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Morphine doesn't need any benzo added to it......Oxy IMO needs something because of the speediness it gives off.

Hydrocodone is fine on its own as well. People like to use Benadryl to potentiate opiates but the only thing Benadryl does is make ms sleepy every time & knocks me out.

Only benzo IMO worth while is Temazepam but its hard to get.

Benzos don't potentiate opiates but more so senergize them.

IMO, no need to add benzos because the last thing anyone needs is a benzo addiction.
 
Benzos have the power to ruin ANY opiate euphoria for me. The combo is only good if the benzo dose is low, otherwise I'm robbed of euphoria and left with a sleepy dull buzz.
 
Yup, benzos reduce or can stop my euphoria in a halt and turn my opiate session into a boring benzo session. I hate the mix of these two. I can not find the journal article, but I had rad somewhere that benzos do indeed reduce the effect of opiates if taken beforehand.
 
THE_REAL_OBLIVION said:
Allows one to save on one's opiate by taking less of it, makes nodding much more probably due to what you said. This is more of a BDD question though honestly..They augment the efficacy of gaba that your own body produces.
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It is also my opinion that they help save my heroin. I don't think they add to my opiate high(or potentiate it), but what they seem to do best is lengthen the time I can go between doses. Since they seem to make time go by fast and they reduce the anxiety of waiting for that next dose.

I might do a little less heroin when on a benzo, too, depending on the situation b/c I might not want to nod out at that time. So that also can help save some, too.

teological said:
Yup, benzos reduce or can stop my euphoria in a halt and turn my opiate session into a boring benzo session. I hate the mix of these two. I can not find the journal article, but I had rad somewhere that benzos do indeed reduce the effect of opiates if taken beforehand.
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I agree, too much is a bad idea. I won't add more than like 10 mg of valium/1 mg of xanax or their equivalents to other benzos. Otherwise I just get really tired, not like nodding out, but just want to sleep. So that is what happens and I wake up knowing I wasted the opiates, which is never good considering the cost most pay for them.
 
TheLostBoys said:
Morphine doesn't need any benzo added to it......Oxy IMO needs something because of the speediness it gives off.

Hydrocodone is fine on its own as well. People like to use Benadryl to potentiate opiates but the only thing Benadryl does is make ms sleepy every time & knocks me out.

Only benzo IMO worth while is Temazepam but its hard to get.

Benzos don't potentiate opiates but more so senergize them.

IMO, no need to add benzos because the last thing anyone needs is a benzo addiction.
Click to expand...

Yep, loads of truth in there, especially the oxycodone needing at least antihistamines. I've had tachycardia from just 40mg oxycodone when I wasn't used to opiates all that much, I was itching everywhere as all hell too, it was hell waiting, cos it was the night before the morning where I could go get my eternal scripts for hydroxyzine and valium. You were also really right about benzo addiction is worse than anything people who only experienced opiate withdrawals.

It took a lot of time before I couldn't "man up" and go the 5-6 days of physical hell that was opi withdrawal, I did it very often and got clean, from opis anyway, i'd replace opiates with speed, at least you get sick of stimulants after a while. I can tough out 3-4 days without valium due to the long half-life, but just when you think you're in the clear and will not experience benz withdrawal, a week later you feel suicidal due to all the physical side effects, that aren't as "strong" as opi withdrawal, but can make one go mad / have seizures.

Everyone has sorta felt the effects of opi withdrawal, imagine your worst flus, being a little worse. At least you have the assurance it will stop soon-ish. With benzos, depending on their half-life and metabolites are way different. Before I was on Valium I was on Rivotril (clonaz) at 3mg and going more than 2 days without it was EXTREME. Ever had your esophagus have spasms because of the total lack of natural gaba in your system ? Goddamn, i was able to taper down my habit by 66% since I'm now at 20mg of valium since 3 years. Getting rid of the rest will mean seeing my psy doc, who usually just renews my scripts by fax, I see him once every year and a half...its way difficult to see a psychiatrist around here unless you are unable to live outside a nuthouse. I'll have to reduce my dosage by 1mg every 3 weeks/until i don't feel a difference, it'll be a really long process, and I will get rid of the suboxone before the benzos for obvious reasons.
 
I find that pretty much every potentiator I've tried has either not worked or dulled the experience. Even DPH and promethazine make my buzz lacking in the euphoria. If you wanna potentiate your opiates use more opiates...
 
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