Which opiate is the best?

[rachel_s_n]

Delete it then.

I think this is a good topic. I like seeing how diffrent people think.

 

[center]

? You're using quotes from days ago that you quite clearly disagree with when I said them then. You just let some fucking sense hit you. Good for you. If you think you won an argument? LOL. I agree with you! Good thinking!

WastedYouth! What a splendid idea!

 

[enoughorangejuice?]

1). intranasal heroin (never IV'd it)
2). IV morphine
3). pp tea (almost as good as IV morphine)
4). IV oxycodone immediate release
5). IV hydromorphone (great rush, but duration is WAY too short)
6). oral oxycodone
7). intranasal oxycodone
8|. oral hydrocodone
9). oral codeine
10). oral tramadol

the rush from IV demerol would be around #3 or #4 but i don't remember it that well because it was right after an IV of versed and fentanyl

 

[-=navel=-]

dextromoramide AKA Palfium which is fcking rare.. but it's supposed to kick methadone right off those mu receptors, which correspond to:

1) Euphoria

2) Depression of breathing

those two are linked no matter what.. so the most euphoric opiate/iod is always the most dangerous. just another trick of that biatch mother nature

NSFW:

Dextro-rotatory isomer of moramide

Dextromoramide

C25H32N2O2. Synthetic substance under international control according to the UN Single Convention 1961 and its amendments, Schedule I. Molecular weight: 392.6. Percentage of anhydrous base: 100.

Dextromoramide (Palfium®, Palphium®, Jetrium®, Dimorlin®) is the right-handed isomer of the moramide molecule. The left handed molecule is called levomoramide, and a mixture of the two is called racemoramide. Its full chemical name is (+)-1-(3-Methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine, and its molecular formula: C25H32N2O2, with an atomic weight of ~392.5. It is one of a group of molecules known as substituted α,α-Diphenyl-γ-Amino-Butyramides.

It is a powerful opioid analgesic, and as such is subject to drug prohibition regimes, both internationally through UN treaties, and by the criminal law of individual states.

It was discovered and patented in 1956 by Dr Paul Janssen at Janssen Pharmaceutica, who also discovered fentanyl, another important synthetic opioid, widely used to treat pain and in combination with other drugs as an anaesthetic. It has the proprietary name Palfium, though as of mid 2004 the drug was dicontinued in the UK due to limited supplies of precursor chemicals.

As is the case with so many drug discoveries, dextromoramide was discovered by accident during research into almost identical compounds, namely α,α-Diphenyl-γ-Dialkyamino-Butyramides, which show no analgesic activity, but are extremely active physiologically as inhibitors of gastric secretions in man.

In many countries dextromoramide is unused, for example the USA, where it is considered a Schedule 1 drug, alongside cannabis and LSD, as having no medicinal uses. It is still rarely used in Australia, but prescription is avoided due to its abuse potential and so use of Palfium is now mainly limited to terminal care.

The typical dose is 5mg four hourly for cancer pain - the drug has a short half life comparable with pethidine. Dextromoramide is also used as a short-acting analgesic for minor surgical procedures. In this case it is administered sublingually and reaches a therapeutic concentration after around 12 minutes.

Dextromoramide was much favoured by drug abusers in Australia in the 1970s. A single case report and a review of the subject appears in the Australian Journal of Pharmacy 1980;61:641-644

 

[danalprazolam]

Out of what you listed, I'd pick intranasal oxycodone.

I've never tried oxymorphone though.

Same here, This and IM oxymorphone are the best ive had.

 

[iameatingjam]

opium
it would be oxy if I didn't get horrible comedowns and things moving in the corner of my eye every 5 seconds.

 

[garuda]

I've come to the conclusion that I'm going to step away from the crowd and scream at the top of my lungs that ALL OPIATES ARE NEGATIVE FOR RECREATIONAL USE.

There, I said it. What good has come out of recreational use of opiates? Yeah. Justification time. Excuse me while I go figure something out.

Which could be said about many things.

What good has ever come out of the recreational use of any drug? Including alcohol, look at all the misery and death that causes.

 

[RifRaf]

For me:

1. Heroin IV
2. Oxycodone Oral
3. Methadone Oral (of course)

I have always loved Methadone because it lasts so long. You don't have to wake up the next morning and go running around looking for something to make you feel better.

 

[KnightMetal]

Heroin, Fentanyl, Dilaudid, Opana, OxyDose, OC, HydroCodone.

The last 4 could be switched around in any way, really, cant decide.

 

[KnightMetal]

I think this is a good topic. I like seeing how diffrent people think.

Whats yours?

 

[LivingOnValium]

Heroin takes the cake out of the ones i've tried
also tried:
morphine
oxycodone

anything weaker isn't worth mentioning.
of all those heroin provided the most enjoyable feeling.

All of the substances mentioned above have been taken by the IV route.

 

[patte4dm]

I.V. oxycodone

 

[Morphinator]

1. IV Morphine/Heroin - the absolute best!
2. Morphine/Heroin (intranasal) - I know low bioavailability, but the high is the greatest from these two drugs.
3. IV Hydromorphone
4. Morphine (oral)
5. Oxycodone (oral)
6. Hydrocodone (oral - especially liquid syrups)


PS: I do not IV much, but I have tried IV drugs. I don't like to make a habit of IV'ing. I'm sure drugs like meperidine (demerol) and oxymorphone would make it on par with hydromorphone on that list if I had tried them. I have heard nothing but good things about them. But still, morphine and heroin rock!

 

[Ham-milton]

Paraluadin, ftw 2

 

[MobiusDick]

I auctually prefer the mylan/gel-less ovre gelled, one reason is the generic non gels, a 100mcg/h patch has 16.9mg of fent in it, compared to 10mg in a duragesic.

Its better because of fents short duration, pure fents kinda harsh on the body, extended release is hella better. I live my life with a chunk of patch in my mouth.

The thing about the short duration of action with fentanyl and drugs of this type is really only for single doses. After just a few days of fentanyl use, you get some multi-compartment redistribution of the drug that increases the volume of distribution. It particularly gets into the fatty compartment outside the CNS, and it slowly releases from there. People who have done this with me report the same thing, and it seems to happen even with ultra-short acting drugs like remifentanil. IF you can do this drug over a series of two days and stay out of withdrawal, it will be at least 3-4 days before you feel any severe withdrawal. And again, we are talking much larger than normal doses here, not standard doses.

But I absolutely agree that Mylan patches are the best, although I thought they had 10.2 mgs of fentanyl base instead of 10 like the gel patches, but I am not certain. But those patches release so much better with a rinse of IPA than the gel patches which require puncture and increase salvation so much that a lot is swallowed. But disrupting the buccal membranes is really effective and this can be done with alcohol/IPA as well. It also pays to make the pH of your mouth alkaline with baking soda or by smoking a cigar (not cigarettes which have an acidic smoke.)

MobiusDick %)

 

[MobiusDick]

Are you looking to prove which opiate is the best? Or are you trying to just get opinions from people about which opiate they like best? Because the last thing we need at Bl is another opinionated thread

Opinion are all we can get from this. Everyone has their own preferences and drug(s) of choice. I like to call this study Pharmacopsychophenomenology.

Mobi%)

 

[FractalStructure]

which woman is the best? kinda hard to say, isnt it? its all about personal taste.

jasoncrest likes buprenorphine. I think oxycodone is quite relaxing, hydrocodone is nice and warm, morphine is bliss (if they are MSIR's, i havent ever gotten any fun experiences with even 200mg crushed up mscontins, but have with 45mg MSIR)

Some swear by H. Some love their fentanyl pops, and some even love codeine tramadol and dihydrocodeine.

If you gave me a choice I'd probably pick either methadone or oxycodone.

Buprenorphine has its ups as well

 

[smokeymcpot42088]

Mobius, the 5 mg Mylan patches have 5.1mgs so 10.2 is most likely accurate.

I have/can get Mylan patches and have came to the conclusion there fairly useless. Couple questions.

Basically what is the most effective way to consume these orally?

From what you said I gather an IPA rinse to the membrane of the patch, alcohol IPA rinse against your buccal membranes,
basify your mouth with baking soda and cigars
place strip of patch in mouth?

If you wouldnt mind going over the procedure you use to consume these orally, pleasse do so, I would GREATLY appreciate it!! I have found these worthless orally in the past, and I know you know your shit and can help with this, saving me countless dollars.

 

[Kurrupt]

In my humble opinion and one I like them (from ones I've personally used, excluding the ones I haven't from my list).

1. Oxycodone (love the energetic and euphoric buzz)
2. Hydromorphone (short lasting but intenste)
3. Fentanyl (though it's not very euphoric, still gets you fucked up)
4. Morphine (have only caught decent buzzes of rediculous doses)

That's about all the opiates/opioids I've used worth mentioning I'm pretty sure :D

For your information Opana (oxymorphone) and Vicodin (hydrocodone) aren't available painkillers in Canada but there may be some syrups containing hydrocodone. I also haven't found a source for heroin and am against IV'ing anyways so I don't see a point in looking for one. Canada is kinda weak with out selection of painkillers but I guess that's ok because you have a better chance of getting prescribed Oxy :D Usually docs go Tylenol 1,2,3 - Percaset - Oxy 10 then work their ways up the Oxy scale until pain is handled suffeciently