Le Junk said:One is likely to become quite talkative, but, unlike marijuana, the conversation does not tend towards giddiness and absurdity.
ibiza chick said:I hear so many people say they get angry & paranoid on coke i'm quite the opposite i'm relaxed, chatty & fun to be with![]()
...Cocaine differs from other local anesthetics in that it also binds to monoamine transporters and blocks the reuptake of catecholamines into the presynaptic nerve terminals. This results in a high degree of adrenergic activity and widespread toxicity. Alpha-adrenergic stimulation, which is largely due to norepinephrine, induces hypertension, whereas beta-receptor stimulation, which is largely due to epinephrine, commonly results in tachycardia (beta1 effect) and hypotension (beta2 vasodilation). Other factors, such as the generation of CNS-excitatory amino acids (glutamate and aspartate), may play a role in CNS hyperactivity and cardiovascular pathology.
--eMedicine - Toxicity, Cocaine <http://www.emedicine.com/med/topic400.htm>Blood pressure: Hypertension commonly is observed in patients with cocaine intoxication and is due to the persistence of adrenergic activity, namely that of norepinephrine at the neurovascular receptor terminals. The blood pressure may be altered by any complication of cocaine use, concomitant disease, or coingestants.
thursday said:K, this thread really needs to die, cuz it's kinda hard to take Bluelight seriously as a harm-reduction website when there are imbecilic discussions like this going on.