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Stimulants Which Med for Comedown? (Theories of Drug Action)

Kilfer said:
5_HT2A your knowledge of the pharmacology involved is far greater than mine but based on personal experience a small dose of Seroquel, say 50mg to 75mg, is all it takes to deal with amphetamine-type stimulant comedown. Higher dosage seem to trigger adverse effects such as jitters and even akathisia attacks. But dosage I mentioned takes you down easy, can even put you to sleep after an hour or so.
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Seroquel is an excellent choice because it's an anti-dopaminergic drug and essentially removes all the access dopamine from your brain, makes you hungry, lets you sleep. A small dose is appropriate 100mg should do it.
 
OK everyone swim.. Had focalin, adderall, Vyvance they were unable to sleep last night and have ingested 60 mg of adderall in the last 2 hr it doesn't seem to be helping what does anyone suggest to be productive at work this afternoon, no real tolerance to stem. Also ingested 90mg Roxy (high tolerance)
 
Benzos have helped me come down and sleep (better than anything else, without any 'bad' effects), as well as people who are long-term amphetamine users. (Who also have a prn benzo for crashing and sleep)
 
As others have said, I have had good experiences with 50-100 mg of seroquel for this purpose...allows you to sleep a more restful, deep sleep than you could otherwise get when coming off amphetamines. benzo's of course are good too, but if you don't have any on hand, seroquel does a great job.
 
Te comedown is going to hit one way or another. The best advice is to eat healthfully, exercise, and sleep. Then, your body can regenerate naturally. There is really no "cure" for a stimulant comedown.
 
benzos are very common for comedowns. i used to use amphetamines years ago when i was young. i just smoked weed to comedown. it's better to just take it orally and at the lowest dose that is beneficial. they work great for learning. they make u go longer for sex too. do too much and you will get whiskey dick. learning becomes harder also. also you should do them earlier in the day so they are more worn off when you go to bed. i know ppl that just take low doses just to keep perked up during the day. they just swallow it and say they dont even really get a comedown. you dont want to be doing a lot of that long term. its hard on the body. i cant even handle the shit anymore.
 
I like to use kratom with amphetamines, during the initial comedown I find in lower doses (where it acts as a stimulant) it boosts the effect and reduces the urge to take more. I also take magnesium and b-vitamins, and find ketamine (or a small dose of MXE) is good for the transition. My thinking it that it may be neuroprotective and NMDA antagonists are good for reducing the onset of tolerance.

Kratom in more opiate level doses can also be helpful at the very end of the night. I usually mix it with OJ and the vitamin C helps speed up the metabolism of any residual amphetamine.

And of course benzos are the gold standard for stimulant comedowns. :)
 
I wouldn't suggest a med while coming down but thats just me because the come down part almost vanished in my experience just by eating while I'm on a binge even an apple every hour or so not even a whole meal helped with my irritability so I just make sure to eat and stay hydrated to stave off the evil come down
 
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