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  • BDD Moderators: Keif’ Richards | negrogesic

which drugs would make good practical antidepressants?

D

Diamorphazepam

Greenlighter
Joined
Mar 15, 2015
Messages
48
im just curious if anyone has been prescribed anything that is not approved already as an antidepressant or taken any illegal drugs long term that has helped with depression?
it cant be something that you took a one of and felt less depressed. It has to be something you took daily for at least a month or so which maintained the anti depressive effect without high or lows.

I noticed ketamine is being researched as an antidepressant. and then there's ALKs 5461
http://en.wikipedia.org/wiki/ALKS-5461 (if u don't already know what it is)

it makes me think that just about any drug if played around with could potentially help depression.
ive been taking bupe for a few days. only 2mg and I feel a little bit better.

I don't know how to define the difference between an ant depressive effect and just feeling high or euphoria. I don't know if theres a defined medical difference which makes it clear?

tramadol seemed to help m motivation. I know tramadol is actualy an SNRI but its not prescribed an an antidepressant though. Maybe it should be.
when I used to smoke nicotine sometimes made me feel better. but they would have to make a long acting nicotine. But that's already similar to bupropion which is used for depression which I havnt tried.
small doses or any opiate have an anti depressant effect. Maybe some you don't get a tolerance to as fast. And you couldn't abuse them. Maybe some people who are doses daily small doses or methadone may know if it has helped with motivation or anything.
 
suboxone and methadone aren't worthwhile antidepressants because you get addicted to them and they stop working once you have a tolerance to them
 
True ^

Any drug that is mind altering and/or will produce drug seeking thoughts or behavior, wouldn't be appropriate for a stable antidepressant. You'll need more as tolerance continues to increase and the highs and lows might make depression worse.

I have heard of Ketamine recently. I am curious about how it is manufactured and prescribed. Thank you for the link. :)
 
LilikoiMoon said:
Tramadol is a strange AD drug for me. In doses of about 100-150mg, it boost my mood and gives me energy/focus , almost like Adderall.
Click to expand...


Same with me, 100mg tramadol is like speed for me......I definitely can't sleep on it. Its an uplifting mood enhancer which is needed now & then.

I've heard of a few people being prescribed tramafol for depression, not many tho.

To invent a pill that lifts the mood, makes you happy w/o a care in the world & isn't addictive, & doesn't cause a tolerance.....well......you will be a billionaire if you invent it.
 
I'd also like to vote for tramadol. Its opiate action is slight at 100-150mg so there is just a gentle mood lift, its very long lasting (8-12 hours for me), and I never have felt the urge to redose. It makes me alert and motivated without increasing my heart rate and it's also great for sleep. Sometimes it lasts until the next morning and really helps me get out of bed and start my day. There is the seizure and tolerance issue but I would be willing to risk that for all the benefits tramadol has.

Also wtf Is that gif Smoky? It keeps annoying me bcz I can't figure out what it is on my small iPhone screen.
 
psilocybin is known to cause neurogenesis in the hippocampus, which is the part of the brain that deteriorates in people with depression, and the spot SSRI's target as well, but psilocybin does a better job of it than SSRI's. Basically, psilocybin does an SSRI's job but better and with less side effects.

Of course, you have to microdose.
 
^tram is a very sketchy drug ive heard of seizures on low doses and seen one on a moderate/high dose..i think the risk out weigh the rewards but it does help with depression

Lyrica or gabapentin work well for my depression and anxiety but of course they're addicting like most mood enhancing drugs.i can take a 300mg lyrica and be in a great mood all day and sleep like a baby at night..also it makes work fun i can get so much done on it and music sounds amazing..i have a tolerance so a good starting dose would be 150mg if u take to much u get the antidepressant effects but u also feel kinda drunk physically but u can think straight
 
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Tramadol is a godsend. I'd like to say that the period of time I was using it was the happiest/ most productive part of my life. It makes you want to talk to everyone, are always happy, and are happy to do things you would normally dread doing. It's super motivational and has a long half like of around 7 hours give or take.

Kanna might be effective you too, but Tramadol beats everything i've tried by a longshot.
 
I took methadone daily for quite a while. I only SOMEWHAT build a tolerance to it. the whole time I took it I still felt slightly less physically anxious. such as shaking and sitting still kind of for the whole time. It made me always want to sleep though & I found it hard to get up or even wake up sometimes. So it didn't increase my energy.
im curious to see how I would feel taking oxycontin daily as it's suppose to be taken as time released. Stabilizing on a dose. maybe it would reduce anxiety without the sedation of methadone. Obviously because it is one of the less sedating opiates.
im not planning on trying this out. just curious. it would have to be given like methadone to prevent up and downs
 
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If you are EXTREMELY depressed I could be inclined to suggest Tramadol too. By extremely depressed I mean a depression that has lasted for years and where you have already tried all existing normal methods like therapy, SSRI, SNRI and what not.

Here is a comparison of the chemical structure of Tramadol and Venlafaxin:
ssri_tramadol_structuresame.png


Tramadol is an inhibitor of the noradrenergic neurotransmitters norepinephrine and serotonin just as SNRIs. I would get extended-release pills as this will give you the most stable level of tramadol in your blood. With extended-release you can take one pill each morning when you wake up. You can start on 50 mg and move up to 100 mg a week later or something if 50 mg isn't enough. Once, I took 100 mg tramadol every day for three months and then stopped without experiencing any withdrawal-symptoms. I the last week I only took the pill every other day though. But you have to be careful. Tramadol IS addictive and it can even make your depression worse. That is why I would call it a last resort possibility.

Concerning the sleep issues. After a while you will sleep very well on tramadol. It is only in the beginning in messes with your sleep.

I hope I made myself clear enough about how dangerous I think the use of tramadol for treatment of depression is.

Edit:
One of the things that are very unpleasant when stopping on Tramadol is the lack of serotonin in your brain. When you influence serotonin through exogenous methods and stop, your own ability to produce serotonin will be damage for a while after you stop.

There is a new drug on the market, though, called Tapentadol. It is very similar to Tramadol, but it doesn't inhibit serotonin reuptake, it is only a norepinephrine reuptake inhibitor. Serotonin is one of the things in tramadol that brings unpleasant withdrawal effects when stopping. That is why I find Tapentadol very interesting. But it is a new drug approved in USA in 2008, so it hasn't been on the market long. I don't know if it will have the same anti-depressant qualities without serotonin though.
 
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Diamorphazepam said:
im just curious if anyone has been prescribed anything that is not approved already as an antidepressant or taken any illegal drugs long term that has helped with depression?
it cant be something that you took a one of and felt less depressed. It has to be something you took daily for at least a month or so which maintained the anti depressive effect without high or lows.

I noticed ketamine is being researched as an antidepressant. and then there's ALKs 5461
http://en.wikipedia.org/wiki/ALKS-5461 (if u don't already know what it is)

it makes me think that just about any drug if played around with could potentially help depression.
ive been taking bupe for a few days. only 2mg and I feel a little bit better.

I don't know how to define the difference between an ant depressive effect and just feeling high or euphoria. I don't know if theres a defined medical difference which makes it clear?

tramadol seemed to help m motivation. I know tramadol is actualy an SNRI but its not prescribed an an antidepressant though. Maybe it should be.
when I used to smoke nicotine sometimes made me feel better. but they would have to make a long acting nicotine. But that's already similar to bupropion which is used for depression which I havnt tried.
small doses or any opiate have an anti depressant effect. Maybe some you don't get a tolerance to as fast. And you couldn't abuse them. Maybe some people who are doses daily small doses or methadone may know if it has helped with motivation or anything.
Click to expand...

Desoxyn really works insanely well for depression, shame they don't prescribe it often for that purpose.
 
Yes bupe is the best for depression, remember less is better! As far as your typical antidepressants, I recommend Zoloft, start at a low dose, see how you feel and then go from there..good luck sweetie!
 
Being someone who has cycled in and out of psychiatric hospitals due to depression related issues, I would suggest opiates, but not just any opiates: for example oxycodone works quite well or oxymorphone is also nice. I feel in some ways benzos are also able to provide depression relief, that being said IDK how long they would make a difference for. And only benzos with long half lives, short half lives are useless to this cause. MDMA in tiny ass doses that are spread out over time could help. LSD if dosed carefully over months could be the key, been there feel good about that thought. Besides that I don't have any relevant thoughts and even then take my thoughts with a shaker or two of salt.

Depression came be due to having an excessive amount of anxiety: this is why benzos could theoretically solve the issue in the short time.

Opiates rock harder than Jack White joining the Queens Of The Stone Age: this is why opiates could improve the depressive state of an individual.
 
Just found this thread. I am personally on Lexapro @ night for my depression. I then discovered tramadol as a use for nerve pain. It uplifted my mood so well during the day I must admit I do take it during the day from time to time. After a while tramadol makes you very sleep/dozey and you'll find that you'll sleep very well at night. Which is also a god send as I get sleeping problems insomnia ect..
But always when mixing SSRIs you must be careful hence why I take them at different times.

Edit: NEVER go cola turkey on anxiety/anti depressants I this stupidly when returning from overseas and went into depersonalisation ect withdrawal and I would NEVER wish that on anyone.

Ciao :-)
 
It's not "practical" by any means, LOL, but I found that heroin actually made a really good anti-depressant. I would take a single hit in the morning and feel great all day long. Not because I was high either, the high from H doesn't last that long. It's strange because other hard drugs aren't like that...I never enjoyed the aftermath of a meth high, for example.

I imagine it's a whole hell of a lot different if you have a physical addiction to it though.
 
TheLostBoys said:
To invent a pill that lifts the mood, makes you happy w/o a care in the world & isn't addictive, & doesn't cause a tolerance.....well......you will be a billionaire if you invent it.
Click to expand...

Uhmmmmmm...not so fast...

If some guy invented such a pill, the Government and it's Crony Capitalists would hire one of their goons to put a bullet in his head. Trust me on that one bro.

There's just too much money being made by the right people that something like this would be quickly swept under the rug and then forgotten about. Sorry to be the bearer of bad news, but that is an indubitable fact.
 
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